Primary cardiac B-cell lymphoma

Proctor, Michael S.; Tracy, Gerald P.; Koch, Lear Von

doi:10.1016/0002-8703(89)90092-6

Cited by 19 publications

(8 citation statements)

References 5 publications

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“…Furthermore, cytogenetic analysis could be performed on centesis fluid to analyze specific translocations. In our study, as well as in 40% of the reviewed cases, diagnosis of primary cardiac lymphoma was obtained by biopsy of cardiac tissue during an explorative thoracotomy or mediastinoscopy [1,3,6,7,9,15,19,23,28,29,32,35,38,39]. Less invasive procedures may be used in critically ill patients, small children, or preg- nant women and may provide diagnosis in 23% of cases.…”

Section: Discussionmentioning

confidence: 97%

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Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

et al. 2002

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Primary cardiac lymphoma is an extranodal non-Hodgkin's lymphoma exclusively located in the heart and/or pericardium, extremely rare in immunocompetent patients, and more frequent in immunodepressed patients. We present 3 retrospectives cases of primary cardiac lymphoma in immunocompetent patients and review 35 cases reported in the literature. Two patients were adults and one was a child. Primary cardiac lymphoma presented with constitutional symptoms in two cases and superior vena caval syndrome in one case. Diagnosis of a tumor mass was made in all cases by transthoracic echocardiography. Primary cardiac lymphoma arose in the heart right chambers in two cases. Histological diagnoses, obtained after thoracotomy, were diffuse large B-cell lymphoma in two cases, and Burkitt's lymphoma in one case. All three cases received chemotherapy, combined with radiotherapy in one patient. Of our patients, 2 are alive and asymptomatic 12 months and 33 months after diagnosis. In conclusion, diagnosis of primary cardiac lymphoma is difficult due to non-specific clinical manifestations and should be considered in patients with a cardiac mass sometimes with pericardial effusion. It is confirmed using transthoracic echocardiography and magnetic resonance imaging and certified using cytology or open biopsy. The only effective treatment is chemotherapy, but prognosis remains poor.

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Section: Discussionmentioning

confidence: 97%

“…It is an extranodal lymphoma involving only the heart and/or the pericardium [5]. We report 3 cases of primary cardiac lymphoma and review 35 cases from the literature [1,2,3,6,7,8,9,10,11,12,15,17,18,19,20,21,22,23,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,41].…”

Section: Introductionmentioning

confidence: 99%

Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

et al. 2002

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“…There has been a substantial improvement of diagnosis with the advent of modern diagnostic techniques. In fact, in the earliest reports, at a time when these technologies were not available, diagnosis was frequently made postmortem, and often no specific treatment could be instituted [29,30,32,35,44,45].…”

Section: Review Of the Literaturementioning

confidence: 99%

Primary Cardiac Lymphoma: Report of Two Cases Occurring in Immunocompetent Subjects

Anghel

Zoli

Petti

et al. 2004

Leukemia & Lymphoma

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Primary cardiac lymphomas (PCLs), involving solely heart and/or pericardium at presentation, are rare events. They are frequently recognized at autopsy and generally carry a poor prognosis due either to a delay in the diagnosis or to infiltration of heart structures. We report here on two patients with large B-cell PCL. One is a 52-year-old man who presented with multiple cardiac tumors infiltrating mainly the right atrium and the inter-atrial septum. Diagnosis was established by ultrasound-assisted transesophageal biopsy of the intra-atrial multilobated tumor mass. He was treated with Rituximab-implemented high-dose sequential (R-HDS) chemotherapy followed by autologous peripheral blood stem cell transplantation, attaining complete response. He had no evidence of disease 24 months from onset. The second patient was a 70-year-old woman who presented with pericardial tamponade and low-output cardiac failure. Despite prompt pericadiocentesis and chemotherapy with cyclophosphamide and vincristine, she died 2 weeks later. Postmortem examination revealed large B-cell lymphoma proliferation confined to the heart. Whether primitive heart localizations represent an independent prognostic factor, and what specific measures should be adopted in patients with this rare presentation is the subject of the present report and review of the literature.

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“…A review of the 21 reported cases of primary car diac lymphoma shows that there are no symptoms or signs that particularly suggest the diagnosis, and clini cal symptoms may be entirely absent (6 cases) [1,3]; the patient may present with features of congestive heart failure (9 cases) [1,4,5) or pericardial effusion (8 cases) [1, our case]; 1 patient each presented with sudden death [1] and chest pain with third-degree atrioventricular block [6]. Sixteen of the 21 patients were only diagnosed post mortem.…”

Section: Discussionmentioning

confidence: 99%

“…Sixteen of the 21 patients were only diagnosed post mortem. Of the 5 diagnosed ante mortem, 2 were diagnosed by myocardial biopsy alone [1,5], 2 were diagnosed by pericardiocentesis alone [1, our case] and 1 was diagnosed by both [6], Three of the 5 patients in whom an ante-mortem diag nosis was made died before treatment could be com menced or soon after due to lethal local complica tions of the disease [1,5,7].…”

Section: Discussionmentioning

confidence: 99%