Primary cardiac sarcoma after breast cancer

Ramalho, Joana; Nunes, Sabrina Versuti; Marques, Irene; Marques, Filipe

doi:10.1136/bcr-2013-008947

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…We can speculate, however, that women receive more chest radiation for breast cancer 22,23 and that blacks have less access to medical care than whites 24 ; however, there may also be genetic and environmental factors that cannot be inferred from this study.…”

Section: Discussionmentioning

confidence: 66%

Characteristics and Survival of Malignant Cardiac Tumors

et al. 2015

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Background-The aim of this study was to investigate the incidence, histopathology, demographics, and survival associated with primary malignant cardiac tumors (PMCTs). Methods and Results-We queried the Surveillance, Epidemiology and End Results (SEER) 18 registry from the National Cancer Institute for all PMCTs diagnosed from 1973 to 2011. We describe PMCT histopathology and incidence, comparing characteristics and survival of these patients with those of patients with extracardiac malignancies of similar histopathology. From a total of 7 384 580 cases of cancer registered in SEER, we identified 551 PMCTs (0.008%). The incidence of PMCT diagnosis is 34 cases per 100 million persons and has increased over time (25.1 in 1973-1989, 30.2 in 1990-1999, and 46.6 in 2000-2011). Most patients are female (54.1%) and white (78.6%) with median age at diagnosis of 50 years. The most common PMCTs are sarcomas (n=357, 64.8%), followed by lymphomas (n=150, 27%) and mesotheliomas (n=44, 8%). Most patients are diagnosed with tissue sample (96.8%). Although use of chemotherapy is not documented in SEER, 19% of patients received radiation and 44% had surgery. After a median follow-up of 80 months, 413 patients had died. The 1-, 3-, and 5-year survival rates were 46%, 22%, and 17% and have improved over the eras, with 1-, 3-, and 5-year survival rates of 32%, 17%, and 14% for 1973 to 1989 and 50%, 24%, and 19% for 2000 to 2011 (P=0.009). Cardiac sarcomas and mesotheliomas are the most lethal PMCTs, with 1-, 3-, 5-year survival rates of 47%, 16%, and 11% and of 51%, 26%, and 23% compared with 59%, 41%, and 34% for lymphomas, respectively (log rank test P<0.001). Patients with cardiac lymphomas and sarcomas are younger and have worse survival than patients with extracardiac disease of similar histopathology (P<0.001). Conclusions-PMCTs are extremely rare and continue to be associated with poor prognosis. Over the past 5 decades, the incidence and survival of patients diagnosed with PMCT appear to have increased.

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Section: Discussionmentioning

confidence: 66%

Characteristics and Survival of Malignant Cardiac Tumors

et al. 2015

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Survival Differences in Men and Women With Primary Malignant Cardiac Tumor: An Analysis Using the Surveillance, Epidemiology and End Results (SEER) Database From 1973 to 2015

Antwi‐Amoabeng

Meghji

Thakkar

et al. 2020

JAHA

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Background No data are available on sex disparities in prevalence and survival for primary malignant cardiac tumors ( PMCT ). This study aimed to compare male and female PMCT prevalence and long‐term survival rates. Methods and Results We utilized the Surveillance, Epidemiology, and End Results ( SEER ) 18 database from the National Cancer Institute for all PMCT s diagnosed between 1973 and 2015. From a total of 7 384 580 cases of cancer registered in SEER , we identified 327 men and 367 women with PMCT s. The majority (78%) of patients were white. Sarcoma was the most common type of PMCT in both men and women (≈60%). Individuals diagnosed with lymphoma exhibited better survival than those with other types of PMCT s. Men were diagnosed at a younger age than women; however, there was no significant difference in overall survival between the sexes. Men diagnosed with PMCT between the ages of 51 and 65 years demonstrated prolonged survival compared with those diagnosed at younger or older ages. There was no difference in survival rates among women based on age at diagnosis. Conclusions PMCT s are rare in both men and women. Tumors tend to be diagnosed at an earlier age in men compared with women, but there is no sex disparity in survival rate. Sarcoma is the most common type of PMCT , and lymphoma is associated with the highest survival rate among both sexes.

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Primary cardiac sarcoma after breast cancer

Cited by 2 publications

References 21 publications

Characteristics and Survival of Malignant Cardiac Tumors

Characteristics and Survival of Malignant Cardiac Tumors

Survival Differences in Men and Women With Primary Malignant Cardiac Tumor: An Analysis Using the Surveillance, Epidemiology and End Results (SEER) Database From 1973 to 2015

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