Primary central nervous system lymphoma in homosexual men. Clinical, immunologic, and pathologic features

Gill, Parkash S.; Levine, Alexandra M.; Meyer, Paul R.; Boswell, William D.; Burkes, Ronald L.; Parker, Jōhn W.; Hofman, Florence M.; Dworsky, Ruth; Lukes, Robert J.

doi:10.1016/0002-9343(85)90277-3

Cited by 153 publications

(27 citation statements)

References 11 publications

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“…The incidence of PCL is significantly increased in patients with severe immunodeficiency including acquired immunodeficiency syndrome (AIDS) (Snyder et al, 1983;Gill et al, 1985). Recent reports indicate that the incidence of PCL is also increasing in apparently nonimmunodeficient subjects, although the reason for these observations remains obscure (Eby et al, 1988).…”

mentioning

confidence: 99%

Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring

Blay

Lasset²,

Carrié³

et al. 1993

Br J Cancer

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confidence: 99%

Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring

Blay

Lasset²,

Carrié³

et al. 1993

Br J Cancer

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“…Entre el pequeño número de pacientes que si recibieron la radiación adecuada el 87% murieron de infecciones oportunistas sin evidencia del linfoma (10). Aunque algunos reportes de series pequeñas sugieren que la quimioterapia es de algún beneficio (13,(36)(37)(38) el uso de la quimioterapia o una modalidad de terapia combinada en pacientes con SIDA y LPSNC continua por establecerse.…”

Section: Discusionunclassified

Diagnóstico y tratamiento de pacientes con linfomas primarios del sistema nervioso central (LPSN) y sindrome de inmunodeficiencia adquirida (SIDA).

Raez¹,

Angulo²,

Restrepo³

2013

Rev Med Hered

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SUMMARYThe incidence of Primary Central Nervous System Lymphoma (PCNSL) is increasing rapidly. PCNSL is an important lethal complication in AIDS patients. Objective: Our objective was to study the natural history and prognostic factors for survival in patients with AIDS related PCNSL. Material and methods: This is a retrospective cohort study of 75 patients with the diagnosis of AIDS related PCNSL followed at Jackson Memorial Hospital University of Miami. Results: The median age was 37 years. Males comprised 84% of the patients and 55% of the patients were Hispanic. The most common HIV risk factors were homosexuality and multiple sexual partners. The median CD4 count was 15/~L and the median LDH was 1.5x normal. CT Scans of the brain showed multiple lesions in 44% of the patients. Single-Photon Emission CT Scan (SPECT) Thallium-201 of the brain was performed in 2/3 of patients. The most common histologies were immunoblastic and large cell lymphoma. Cranial radiation was given to 72% of the patients and 55% of them did not completed. The median survival of the group was 1.3 months. Univariate and multivariate analysis showed that longer survival was associated with good performance status (ECOG=1-2 Vs 3-4). The presence of prior opportunistic infections, risk factors for AIDS, CD4 counts, level of LDH, ethnicity, gender, duration of symptoms before diagnosis, and race did not influence survival. Conclusions: PCNSL is a neoplasm with a very poor prognosis and short survival even with CNS radiation therapy. Performance status appears to be the main prognostic factor for survival. No significant differences in presentation or outcome were detected between the Hispanic and non-Hispanic patients. RESUMENLa incidencia del linfoma primario del sistema nervioso central (LPSNC) ha crecido rápidamente. El LPSNC as una complicación letal en pacientes con SIDA. Objetivo: Nuestro objetivo fue estudiar la historia natural, métodos diagnósticos, al tratamiento y los factores pronósticos para la sobrevida de 75 pacientes con LPSNC y SIDA seguidos en el Jackson Memorial Hospital/Universidad de Miami. Resultados: La edad media fue de 37 años. El 84% de los pacientes eran hombres y el 55% hispanos. Factores de riesgo más comunes para SIDA fueron homosexualidad y múltiples compañeros sexuales. La cuenta promedio de CD4 fue de 15/ul y al promedio de LDH fue 1.5 veces al normal. La tomografía computarizada del cerebro mostraba lesiones múltiples en el 44% de los pacientes. Gammagrafia computarizada de emisión de fotones con talio-201 (SPECT) del cerebro se realizó en 2/3 de los pacientes. Las histologías más comunes en las biopsias fueron: linfoma inmunoblástico y linfoma de células grandes. La radiación craneana fue ineficiente en el 50% de los pacientes tratados. La sobrevida promedio del grupo fue de 2.2 meses. Análisis univariado y multivariado mostraron que la mayor sobrevida se asociaba con una buena capacidad funcional (ECOG=1-2 vs 3-4). La presencia previa de infecciones oportunistas, la presencia de factores de riesgo de SID...

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“…AIDS is now the most common risk factor for the development of PCNSL. Most of these tumors are found in immunocompromised young men who have had sex with men and who already have far-advanced HIV disease (Formenti et al, 1989;Gill et al, 1985;So et al, 1986). The lymphoma is usually a secondary manifestation of AIDS.…”

Section: Site Of Originmentioning

confidence: 99%

AIDS‐related non‐Hodgkin's lymphomas

Krause

2005

Microscopy Res & Technique

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This work reviews the current status of non-Hodgkin's lymphoma (NHL) in HIV infected patients. HIV infection remains at significantly increased risk for the development of NHL. The great majority of these lymphomas are high-grade monoclonal B-cell neoplasms often occurring in unusual sites. A number of genetic abnormalities have been found but additional studies are necessary to understand the etiology and pathogenesis of NHL in the setting of HIV infection. The cases in this paper have been seen on the Hematopathology service of the Tulane Health Sciences Center.

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Primary central nervous system lymphoma in homosexual men. Clinical, immunologic, and pathologic features

Cited by 153 publications

References 11 publications

Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring

Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring

Diagnóstico y tratamiento de pacientes con linfomas primarios del sistema nervioso central (LPSN) y sindrome de inmunodeficiencia adquirida (SIDA).

AIDS‐related non‐Hodgkin's lymphomas

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