Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features

Abstract

Our findings suggest that the presence of 6p25.3 rearrangement might be related to this particular biphasic pattern.

Biphasic pathological pattern in transformed mycosis fungoides not associated with DUSP22–IRF4 translocation

“…Cutaneous lymphomas with a dual‐component lymphocyte infiltrate were recently reported in three cases of primary cutaneous ALCL and in 12 cases of indolent Lyp . However, in contrast to these cases, in our case the deep infiltrate was present exclusively in the subcutis, and was separated from the upper epidermotropic infiltrate by a dermis free of tumoral cells.…”

“…Whether this peculiar histological feature has prognostic significance is unknown. In all reported cases, lymphoma had an indolent course, with no progression towards a systemic form and no recurrence after tumour excision . In our patient, irradiation of the nodules led to complete and long‐lasting local remission.…”

“…It is defined by the onset of >25% of enlarged lymphocytes, usually expressing CD30, and more than four times the size of normal lymphocytes, either diffuse or organised in sheets in the dermal infiltrate. Recently, an unusual biphasic pathological pattern was reported in lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large‐cell lymphoma (ALCL), which was consistently associated with DUSP22 – IRF4 rearrangement . We report a case of transformed MF (TMF) with a biphasic infiltrate not associated with DUSP22 rearrangement.…”

Secondary cutaneous involvement by systemic anaplastic lymphoma kinase‐negative anaplastic large‐cell lymphoma with 6p25.3 rearrangement

“…Sir: We read with interest the recent report by Onaindia et al . describing three primary cutaneous anaplastic large‐cell lymphomas (ALCLs) with 6p25.3 rearrangements and histological features similar to those that we have described in cases of lymphomatoid papulosis (LyP) bearing this rearrangement .…”

New developments in the pathology of malignant lymphoma. A review of the literature published from August 2014 to October 2014

“…DUSP22-IRF4 locus translocation is present in 20-57 % of C-ALCLs and has also been described in a series of 11 LP patients. Onaindia et al [36] collected three cases of C-ALCL with histological features similar to the ones described in the new variant of LP with 6p25.3 rearrangement as detected by FISH. The three cases showed distinctive histological and immunohistochemical features: a diffuse dermal infiltrate of atypical medium-to-large cells and marked epidermotropism with small, atypical intraepidermal lymphocytes.…”