Primary cutaneous CD30‐positive large cell lymphoma

Abstract

Primary cutaneous CD30-positive large cell lymphoma is a recently described entity, recognized by immunohistochemical criteria. Spontaneous regression may occur and although relapses are frequent, most patients have a favourable prognosis. We describe a 83-year-old woman with a large ulcerated tumour on her right forearm, with 2 months evolution. Histological and immunohistochemical examination revealed a CD30-positive large cell lymphoma. Systemic involvement was not detected. The tumour regressed spontaneously. Cutaneous relapses occurred one year later, all with spontaneous regression. After a 2-year follow-up period, the patient is well, without concurrent extracutaneous disease. This case is in keeping with other reports of spontaneous regression and favourable outcome of this type of cutaneous lymphoma.

CD30+ lymphoma simulating orf

“…Systemic polychemotherapy should only be considered in cases of more generalized skin lesions and in those with extracutaneous involvement. Given the possibility of spontaneous regression, some authors consider it appropriate to delay treatment for several weeks in the case of solitary lesions 11,12 …”