“…The optimal treatment for PCSMP‐TLPD has not yet been defined. However, various therapeutic options have been used for solitary lesions, including surgical excision, radiotherapy or a combination of both , as well as topical, intralesional or oral steroids , doxycycline monohydrate , amoxicillin , cryocautery and bexarotene . Systemic chemotherapy (including cyclophosphamide either as monotherapy or in association with prednisolone) , multi‐agent chemotherapy (as cyclophosphamide, hydroxydaunomycin, oncovin and prednisone (CHOP) therapy) and systemic interferon‐alfa have been used for patients with multiple aggressive lesions, which are now considered mostly as true lymphomas rather than cases of PCSMP‐TLPD.…”