Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients

Kodama, Kazuo; Massone, Cesare; Chott, Andreas; Metze, Dieter; Kerl, Helmut; Cerroni, Lorenzo

doi:10.1182/blood-2005-03-1175

Cited by 225 publications

(228 citation statements)

References 36 publications

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“…9 However, the results of the present study and other studies suggest that expression of neither FOXP1 nor Mum1/IRF4 has prognostic significance in the group of primary cutaneous large B-cell lymphoma, leg type. 24 In primary cutaneous follicle center lymphoma, an expression pattern similar to that of normal centrocytes and centroblasts was observed supporting their germinal center cell-origin. The tumor cells expressed early B-cell transcription factors Pax-5 and PU.1, germinal center marker Bcl-6, transcription factors Oct2 and BOB.1, but not the plasma cell and ABC markers Mum1/IRF4, Blimp-1 and FOXP1.…”

Section: Discussionmentioning

confidence: 81%

Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma

et al. 2006

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Expression patterns of eight transcription factors involved in different stages of B-cell development were investigated in a large group of primary cutaneous B-cell lymphomas and compared with expression patterns during normal B-cell development. The following transcription factors were investigated: Pax-5, PU.1, Oct2, BOB.1, Bcl-6, Mum1/IRF4, Blimp-1 and FOXP1. Primary cutaneous large B-cell lymphomas, leg type showed aberrant coexpression of Bcl-6 and Mum1/IRF4 and in addition strong expression of FOXP1. Expression of FOXP1 and Mum1/IRF4 strongly suggests an activated B-cell type of origin. In contrast, primary cutaneous follicle center lymphomas showed expression of Bcl-6, Pax-5, PU.1, Oct2 and BOB.1, but not of Mum1/IRF4, Blimp-1 and FOXP1. Primary cutaneous marginal zone B-cell lymphoma showed expression of Pax-5, PU.1, Oct2 and BOB.1, but not Bcl-6 by the neoplastic B-cells, and Mum1/IRF4 and Blimp-1 by the neoplastic plasma cells. In conclusion, in primary cutaneous follicle center lymphoma and primary cutaneous marginal zone B-cell lymphoma expression patterns were observed similar to their supposed benign counterparts, germinal center B-cells and postgerminal center B-cells, respectively, which might reflect their indolent clinical behaviour and excellent prognosis. In contrast, the activated B-cell expression pattern in the group of primary cutaneous large B-cell lymphoma, leg type may contribute to its poor prognosis and Mum1/IRF4 and FOXP1 may serve as additional diagnostic markers for this type of primary cutaneous B-cell lymphoma.

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Section: Discussionmentioning

confidence: 81%

Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma

et al. 2006

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“…If a causal link between some cases of MF and Bb infection could be confirmed, a specific antibiotic therapy might be useful to improve the disease outcome even though MF is a T-cell lymphoma. In fact, there are already reports of primary cutaneous B-cell lymphomas responding to antibiotic therapy designed to treat Bb infection (Hofbauer et al, 2001) even though the findings about the association between Bb and B-cell lymphomas are controversial (Goodlad et al, 2000;Kodama et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides: is it a Borrelia burgdorferi-associated disease?

et al. 2006

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Mycosis fungoides (MF) is the most frequently found cutaneous T-cell lymphoma with an unknown aetiology. Several aetiopathogenetic mechanisms have been postulated, including persistent viral or bacterial infections. We looked for evidence of Borrelia burgdorferi (Bb), the aetiologic agent of Lyme disease (LD), in a case study of MF patients from Northeastern Italy, an area with endemic LD. Polymerase chain reaction for the flagellin gene of Bb was used to study formalin-fixed paraffin-embedded lesional skin biopsies from 83 patients with MF and 83 sex-and age-matched healthy controls with homolocalised cutaneous nevi. Borrelia burgdorferi-specific sequence was detected in 15 out of 83 skin samples of patients with MF (18.1%), but in none out of 83 matched healthy controls (Po0.0001). The Bb positivity rates detected in this study support a possible role for Bb in the aetiopathogenesis of MF in a population endemic for LD.

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“…Approximately two-thirds of these lymphomas are of T-cell origin, and the pathogenesis and management of both T-and B-cell cutaneous lymphomas have been recently reviewed. [1][2][3][4][5][6] The most common form of cutaneous T-cell lymphoma (CTCL) is mycosis fungoides (MF), accounting for around 60% of new cases. Sé zary syndrome (SS) is much rarer and accounts for only 5% of CTCL cases.…”

Section: Introductionmentioning

confidence: 99%