Primary diffuse large B‐cell lymphoma of the mandible: A case report

Abstract

IntroductionLymphomas are a heterogeneous group of malignant neoplasms of lymphocytes and their precursor cells. Lymphoma is seen 3.5% of all intraoral malignancies and is the second most common neoplasm after the squamous cell carcinoma in the head and neck region. Diffuse large B‐cell lymphomas (DLBCL), which is a subtype of non‐Hodgkin lymphoma, are seen mostly in the paraoral region.Case presentationAn 82‐year‐old woman was referred with a localised swelling of the mandibular buccal mucosa for 3 months. Excisional biopsy revealed the diagnosis of DLBCL in the mandible and chemotherapy regimen started immediately. However, patient died during treatment.ConclusionsNon‐Hodgkin's lymphomas would be late‐ or misdiagnosed in the perioral region that may result poor prognosis.

Primary Extra Nodal Diffuse Large B-Cell Lymphoma of the Maxillary Sinus with Symptoms of Acute Pulpitis

“…Considering that 6-8 cycles of combined chemotherapy with R-CHOP-21 is the most widely used regimen for patients from 60 to 80 years of age, rituximab was added to the CHOP regimen for the patient in our case, though there is limited experience of the use of anti-CD20 medication during maintenance or consolidation for NHL initial presentation. The average time, reported in previous literature, to arrive at a definitive diagnosis for lymphoma which manifested as a toothache was approximately 5 months [ 5 , 15 , 16 ], while that of our case was about 1 month. With comprehensive inspection and prompt treatment, the patient's symptoms resolved, and no recurrence was seen in the following 5 years.…”

Diffuse Large B Cell Lymphoma of the Maxilla. A Rare Case Report Emphasizing Differential Diagnosis of Maxillary Involvement

“…Lymphomas are malignant neoplasms of lymphocytes and their precursor cells. Freeman et al reported 28% of extra-nodal sites of NHL in the head and neck area and 2% in the oral cavity [6]. Traditionally lymphoma is classified into Hodgkin's (HL) and non-Hodgkin's lymphoma (NHL) and NHL involves the extra-nodal site including the gastrointestinal tract, central nervous system, and skin as well as in the head and neck area involving waldeyer's ring, buccal mucosa, tongue, maxilla, and mandible [7].…”

“…The first line therapy of treatment of DLBCL is CHOP (cyclophosphamide, hydroxy doxorubicin, oncovin, and prednisolone). The early stage of DLBCL is managed by both combinations of chemotherapy and radiotherapy [6].…”

Follicular lymphoma manifests as multiple erosive and proliferative lesions of the oral mucosa: case report and brief literature review

“…According to a study by Barone S et al, the most commonly involved sites are in the soft tissues of oral cavity, with an incidence rate presenting as 38.4%, 19.2%, and 11.5% for buccal mucosa, tongue and gingiva [ 44 ]. As for the clinical appearance, lymphoma occurring in the gingiva, buccal mucosa, and palate usually manifests as ulceration (Table 2 ) [ 39 , 45 – 56 ], while that of FL has been discussed above, and masses or nodular lesions may be observed or palpated under the mucosa of the palate, buccal, and tongue [ 39 , 45 , 50 , 51 , 57 – 60 ]. Swelling of the lip, palate, gingiva, or buccal mucosa may serve as alternative oral signs of lymphoma [ 61 – 64 ].…”