Primary Dural Spinal Lymphoma Presentation of a Rare Spinal Tumor Case

Çeçen, Dilber Ayçiçek; Tatarlı, Necati; Süslü, Hikmet Turan; Özdoğan, Selçuk; Barışık, Nagehan Özdemir

doi:10.1155/2015/639253

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…Clinical presentation of spinal lymphoma typically includes weakness, numbness, and progressive difficulty in ambulation. 10 The thoracic spine is the most commonly affected site, followed by the cervical, less commonly the lumbar region, and most of them are solitary. 11 , 12 The present case presented with neck pain and which was followed by limbs weakness and then subsequently quadriplegia.…”

Section: Discussionmentioning

confidence: 99%

Primary Intradural Extramedullary Spinal Burkitt’s Lymphoma: A Case Report

Sereke

Bongomin

Muyinda

2020

IMCRJ

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Background: Non-Hodgkin's lymphoma (NHL) rarely involves the spine primarily, and if it does, is almost always associated with advanced disease. Case Presentation: An 8-year-old male presented with a one month history of nuchal pain followed by stiffness and rapidly progressive upper and lower limb weakness. He was seronegative for HIV and EBV. Computed tomography myelogram and magnetic resonance imaging of the cervical and thoracic spine showed a long segment (C2 to T1) complete absence of cerebrospinal fluid signal and mildly enhancing intradural extramedullary lesion with an extradural and right paravertebral muscle extension, respectively. Post-excision biopsy histopathology and immunohistochemistry confirmed the diagnosis of a CD 10+, CD20+, CD45+, Bcl-2+, Ki67+, and EBER in situ hybridization for EBV negative, Burkitt's lymphoma (BL). Cytogenetic analysis showed chromosomal translocations of 8q24. CHOP plus intrathecal cytarabine, methotrexate was given as chemotherapy regimen. 1.8 grays (Gy) per fraction to the local area for an average total dose of 36 Gy was given with a resultant significant clinical improvement. Conclusion:Though considered uncommon spinal canal tumors, BL should be in the differential diagnosis, if multilevel involvement is demonstrated on imaging.

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Section: Discussionmentioning

confidence: 99%

Primary Intradural Extramedullary Spinal Burkitt’s Lymphoma: A Case Report

Sereke

Bongomin

Muyinda

2020

IMCRJ

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“…The pathogenesis of PSEL is still unclear, and many hypothesis have been formulated, including the role of chronic inflammatory process, chronic infection, autoimmune disease, and the meningoepithelial component. 6 …”

Section: Discussionmentioning

confidence: 99%

Primary Spinal Epidural Lymphoma As a Cause of Spontaneous Spinal Anterior Syndrome: A Case Report and Literature Review

et al. 2017

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Background Primary spinal epidural lymphoma (PSEL) is one of the rarest categories of tumors. Spinal cord compression is an uncommon primary manifestation and requires to be treated with surgery for the purpose of diagnosis and decompression. Case Presentation A 45-year-old man presented with a new onset thoracic pain and progress to an anterior spinal syndrome with hypoesthesia and loss of thermalgesia. Magnetic resonance image showed a paravertebral mass that produces medullary compression at T3. The patient was taken up to surgery, where the pathology examination showed a diffuse large B-cell lymphoma. Conclusions PSEL is a pathological entity, which must be considered on a middle-aged man who began with radicular compression, and the treatment of choice is decompression and biopsy. The specific management has not been established yet, but the literature suggests chemotherapy and radiotherapy; however, the outcome is unclear.

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“…6 DLBCL is the most common category, representing approximately 30% of all NHL. Immunohistochemically, the large lymphoid cells were CD20 þ and CD3 -.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

J Neurol Surg Rep

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IntroductionPrimary spinal cord tumors are one of the rarest categories of tumors, representing approximately 4 to 16% of all tumors arising from the central nervous system (CNS). 1 An epidural location for lymphoma is observed in 0.1 to 6.5% of the cases.We describe the diagnostic and management of a 45-yearold man who presented an anterior spinal syndrome secondary to an epidural lesion, which had a histological confirmation of a diffuse large B-cell lymphoma (DLBCL). Case PresentationA 45-year-old man presented with a new onset of highintensity thoracic pain limiting his movements; a month later he was accompanied by decrease in the strength of the left pelvic limb. After 2 months, he started with weakness of both lower limbs and impaired urinary sphincter control.The neurologic examination demonstrated a minor motor impairment of lower limbs and reflexes were hyperactive. He presented a sensory level of hypoesthesia and loss of thermalgesia at T5. Anal sphincter tone was without damage, negative Hoffman, Trömner and Babinski's sign.Magnetic resonance images showed a paravertebral mass hypointense on T1 and T2 with homogeneous enhancement, which produced medullar compression at T3 (►Figs. 1 and 2).The patient was taken into surgery, where we performed a neural decompression by posterior way and biopsy of the extradural spinal lesion. Intraoperatively, we found a fibrotic, gray-colored, vascularized lesion on the right side above the T3-T4 level (►Fig. 3). Keywords► spinal epidural lymphoma ► epidural ► spinal compression AbstractBackground Primary spinal epidural lymphoma (PSEL) is one of the rarest categories of tumors. Spinal cord compression is an uncommon primary manifestation and requires to be treated with surgery for the purpose of diagnosis and decompression. Case Presentation A 45-year-old man presented with a new onset thoracic pain and progress to an anterior spinal syndrome with hypoesthesia and loss of thermalgesia. Magnetic resonance image showed a paravertebral mass that produces medullary compression at T3. The patient was taken up to surgery, where the pathology examination showed a diffuse large B-cell lymphoma. Conclusions PSEL is a pathological entity, which must be considered on a middle-aged man who began with radicular compression, and the treatment of choice is decompression and biopsy. The specific management has not been established yet, but the literature suggests chemotherapy and radiotherapy; however, the outcome is unclear.

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Primary Dural Spinal Lymphoma Presentation of a Rare Spinal Tumor Case

Cited by 7 publications

References 11 publications

Primary Intradural Extramedullary Spinal Burkitt’s Lymphoma: A Case Report

Primary Intradural Extramedullary Spinal Burkitt’s Lymphoma: A Case Report

Primary Spinal Epidural Lymphoma As a Cause of Spontaneous Spinal Anterior Syndrome: A Case Report and Literature Review

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