Primary endobronchial amyloidosis: A rare case of endobronchial tumor

Lal, Amos; Akhtar, Jamal; Khan, Mohammad Saud; Chen, Yayan; Goldman, Yaron

doi:10.1016/j.rmcr.2018.02.007

Cited by 6 publications

(15 citation statements)

References 25 publications

(40 reference statements)

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“…In our case, the clinical team did forgo proning the patient due to concerns of tracheobronchial injury though arguably, a CT chest and repeated bronchoscopies could not delineate a definitive tracheal injury. Bedside bronchoscopy and CT chest with 3D reconstruction remain the gold standard for diagnosing airway trauma [32][33][34][35][36][37]. Needless to say, a high index of clinical suspicion is of paramount importance to avoid any delay in diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Pneumothorax and pneumomediastinum in COVID-19 acute respiratory distress syndrome

Lal

Mishra

Akhtar

et al. 2021

Monaldi Arch Chest Dis

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COVID-19 has involved numerous countries across the globe and the disease burden, susceptible age group; mortality rate has been variable depending on the demographical profile, economic status, and health care infrastructure. In the current clinical environment, COVID-19 is one of the most important clinical differential diagnoses in patients presenting with respiratory symptoms. The optimal mechanical ventilation strategy for these patients has been a constant topic of discussion and very importantly so, since a great majority of these patients require invasive mechanical ventilation and often for an extended period of time. In this report we highlight our experience with a COVID-19 patient who most likely suffered barotrauma either as a result of traumatic endotracheal intubation or primarily due to COVID-19 itself. We also aim to highlight the current literature available to suggest the management strategy for these patients for a favorable outcome. The cases described are diverse in terms of age variance and other comorbidities. According to the literature, certain patients, with COVID-19 disease and spontaneous pneumothorax were noted to be managed conservatively and oxygen supplementation with nasal cannula sufficed. Decision regarding need and escalation to invasive mechanical ventilation should be taken early in the disease to avoid complications such as patient self-inflicted lung injury (P-SILI) and barotrauma sequelae such as pneumothorax and pneumomediastinum Recent systematic review further supports the fact that the use of non-invasive ventilation (NIV) in certain patients with COVID-19 pneumonia may give a false sense of security and clinical stabilization but has no overall benefit to avoid intubation. While invasive mechanical ventilation may be associated with higher rates of barotrauma, this should not mean that intubation and invasive mechanical ventilation should be delayed. This becomes an important consideration when non-intensivists or personnel with less experience provide care for this vulnerable patient population who may rely too heavily on NIV to avoid intubation and mechanical ventilation.

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Section: Discussionmentioning

confidence: 99%

Pneumothorax and pneumomediastinum in COVID-19 acute respiratory distress syndrome

Lal

Mishra

Akhtar

et al. 2021

Monaldi Arch Chest Dis

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“…Amyloidosis is characterised by the deposition in extracellular and/or intracellular tissues of abnormal proteins in a fibrillar form: the amyloid. These amyloid deposits may cause organ dysfunction [ 3 ]. Amyloidosis can be acquired or hereditary, primary or secondary, localised or systemic.…”

Section: Discussionmentioning

confidence: 99%

“…Although a rare disorder, primary TBA is the most common localised form of respiratory amyloidosis. According to the literature, only 0.5% of all symptomatic tracheobronchial lesions are amyloid lesions [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

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A persistent wheeze

Mendes

Santos

Figueiredo

et al. 2021

Breathe

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“…In their report dated 20 th March 2020, CDC mentions that 20% of the hospitalized patients and 12% of the intensive care patients from US belong to age range of 20 to 44 years (10). Amongst the comorbidities, hypertension, cardiovascular disorders, cerebrovascular disorders and diabetes are the top medical conditions who had more severe disease and required intensive care as compared to individuals without these comorbidities (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Specific subset of population like patients suffering from cancer, transplant recipients or other benign blood disorders need special attention for their underlying disease (17)(18)(19)(20).…”

Section: Demographic Details Of the Patientsmentioning

confidence: 99%

Trajectory of the COVID-19 pandemic: chasing a moving target

Sahu¹,

Mishra²,

Lal³

2020

Ann Transl Med

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The spread of COVID-19 has already taken a pandemic form, affecting over 180 countries in a matter of three months. The full continuum of disease ranges from mild, self-limiting illness to severe progressive COVID-19 pneumonia, multiorgan failure, cytokine storm and death. Younger and healthy population is now getting affected than before. Possibilities of airborne and fecal oral routes of transmission has increased the concern. In the absence of any specific therapeutic agent for coronavirus infections, the most effective manner to contain this pandemic is probably the non-pharmacological interventions (NPIs).The damage due to the pandemic disease is multifaceted and crippling to economy, trade, and health of the citizens of the countries. The extent of damage in such scenarios is something that is beyond calculation by Gross Domestic Product rate or currency value of the country. Unfortunately, unlike many other diseases, we are still away from the target antiviral drug and vaccine for severe acute respiratory syndrome (SARS-CoV-2) infection. The prime importance of NPIs like social distancing, staying in home, work from home, self-monitoring, public awareness, self-quarantine, etc. are constantly being emphasized by CDC, WHO, health ministries of all countries and social media houses. This is time of introspection and learning from our mistakes. Countries like China and South Korea who were initially the most hit countries could contain the disease spread by liberal testing of their population, stringent quarantine of people under investigation and isolation of the positive cases. Rest of the countries need to act urgently as well to bring an immediate halt in the community transmission.

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Primary endobronchial amyloidosis: A rare case of endobronchial tumor

Cited by 6 publications

References 25 publications

Pneumothorax and pneumomediastinum in COVID-19 acute respiratory distress syndrome

Pneumothorax and pneumomediastinum in COVID-19 acute respiratory distress syndrome

A persistent wheeze

Trajectory of the COVID-19 pandemic: chasing a moving target

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