Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the vagina in a 54-year-old woman: a case report

Abstract

This is the oldest but virgin case, treated with radiation completely, of primitive neuroectodermal tumor located in the vagina reported in the literature.

Importance of studying primitive neuroectodermal tumors and extraosseous Ewing's sarcoma of the vagina and vulva (Review)

“…The majority of the identified patients were young (<30 years old), and the youngest and the oldest of the patients were 3 years and 87 years, respectively (Table I) (5,9,13,. Regarding vaginal PNT and extraosseous Ewing's sarcoma, 15 cases (14 and 1, respectively) have been recorded in the literature, and they were reported to occur in patients aged 12-54 years, and the first case was described in 1970 (Table II) (12,21,25,(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54).…”

Extraosseous Ewing's sarcoma arising in the perineal region (Rectovaginal Septum)

“…1 The occurrence of primary ES in the female genital tract is exceptional, and only rare cases arising from the ovary, uterus, vagina, and vulva have been reported. [2][3][4][5][6][7] Moreover, only one case of primary ES arising in the rectovaginal septum has been documented. 8 Herein, we describe the second documented case of ES arising in the perineal region (rectovaginal septum) and discuss the usefulness of cytological examination in the diagnosis of this lesion.…”

An unusual presentation of extraskeletal vaginal Ewing sarcoma: A case report

“… Author Location Treatment Prognosis Metastatic? Rekhi 2019 [ 6 ] Cervicovaginal Chemotherapy Unknown/Lost to follow-up Unknown Rekhi 2019 [ 6 ] Anterior vaginal wall Chemotherapy (VDC/IE) & external beam radiation Disease free at 18 months post-treatment No Cross 2017 [ 7 ] Vaginal, posterior to bladder Chemotherapy Metastatic spread to lung and brain; on palliative treatment Yes Cross 2017 [ 7 ] Posterior vaginal Chemotherapy and surgical resection Disease free at 12 months post-treatment No Modi 2016 [ 8 ] Lateral wall of the vagina Chemotherapy and external beam radiation Disease free at treatment conclusion No Pang 2012 [ 9 ] Anterior and posterior vaginal External beam radiation plus brachytherapy Death 18 months post-treatment completion due to disease progression Yes Bancalari 2012 [ 10 ] Retrocervical posterior vaginal wall Chemotherapy and surgical resection Disease free at 20 months post-diagnosis No Machado 2013 [ 11 ] Upper third of the anterior vaginal wall Chemotherapy Death 22 months after diagnosis due to disease progression Yes Rekhi 2010 [ 12 ] Anterior and posterior vaginal walls and anterior sacrum Chemotherapy (VDC/IE) Disease free at completion of induction phase No Yip 2009 [ 13 ] Vaginal introitus External beam radiation, subsequent Surgical resection of metastasis Disease free at 18 months post-resection. Yes Al-Tamimi 2009 [ …”