Primary extraosseous intracranial Ewing′s sarcoma: Case report and literature review

Choudhury, Krishnangshu Bhanju; Sharma, Shreya; Kothari, Ramesh; Majumder, Anjali

doi:10.4103/0971-5851.89798

Cited by 29 publications

(34 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[68] In the present case, our initial differential diagnosis included more common tumors such as meningioma though age or medical history of the patient was not in favor. In fact, the combination of its infrequent location in the intradural compartment, along with the lack of distinctive imaging characteristics, compounds to the diagnostic pitfalls encountered with Ewing’s sarcoma in such locations.…”

Section: Discussionmentioning

confidence: 94%

Dural metastasis of Ewing′s sarcoma

Nsir

Boughamoura²,

Maatouk³

et al. 2013

Surg Neurol Int

View full text Add to dashboard Cite

Background:Metastatic Ewing’s sarcoma to the central nervous system is an uncommon condition and debate concerning the true origin of its metastases is still up to date. To the best of our knowledge, only two cases of dural metastatic Ewing’s sarcoma have been published in the English medical literature. We present an additional case in a 24-year-old female and discuss the pathogenesis of these unusual tumors with review of the relevant literature concerning their treatment and outcome.Case Description:A 24-year-old female with previous history of pelvis Ewing’s sarcoma and recently discovered lung metastases, presented with moderate headache for the past 2 weeks and weakness in her left leg for the past 2 days. Computed tomography scan and magnetic resonance imaging revealed an extra-axial right frontoparietal mass invading the superior sagittal sinus but with clear delineation with brain parenchyma. Imaging features were suggestive of a meningioma as no abnormalities in the skull abutting to the tumor were noted. The patient underwent surgical removal of her tumor. Near total resection was achieved and histological examination showed evidence of metastatic Ewing’s sarcoma. Postoperative adjuvant radiation and chemotherapy were administered. The patient improved well postoperatively with full recovery of her motor weakness. She is symptom free with no signs of progression, at most recent follow-up, 8 months after surgery.Conclusion:Despite its rarity, metastatic Ewing’s sarcoma must be considered in the differential diagnosis of extra-axial dural masses particularly meningiomas.

show abstract

Section: Discussionmentioning

confidence: 94%

Dural metastasis of Ewing′s sarcoma

Nsir

Boughamoura²,

Maatouk³

et al. 2013

Surg Neurol Int

View full text Add to dashboard Cite

show abstract

“…15 Overexpression of CD99, a transmembrane protein encoded by the MIC-2 gene, is another helpful marker detected by immunohistochemistry. 18 The completed COG AEWS0031 protocol reported improved clinical outcomes using intervalcompressed chemotherapy, which has become the standard of care for Ewing sarcoma, in addition to local control with maximal surgical resection and focal radiation. 16 In systemic Ewing sarcoma, neoadjuvant chemotherapy has also been shown to improve cytoreduction and achieve local control of tumors prior to surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…16 Current first-line chemotherapy for Ewing sarcoma includes vincristine, doxorubicin, and cyclophosphamide, alternating with ifosfamide and etoposide. 18 The completed COG AEWS0031 protocol reported improved clinical outcomes using intervalcompressed chemotherapy, which has become the standard of care for Ewing sarcoma, in addition to local control with maximal surgical resection and focal radiation. 9 Based on our review of the literature, ours is the third case of primary Ewing sarcoma arising from the squamous temporal bone reported to date.…”

Section: Discussionmentioning

confidence: 99%

Primary Ewing sarcoma of the squamous temporal bone with intracranial and extracranial extension: A rare cause of sudden sensorineural hearing loss

Choi

2018

Head & Neck

View full text Add to dashboard Cite

Background Primary Ewing sarcoma of the cranial bone is rare, accounting for only 1% of all Ewing sarcomas. Primary Ewing sarcoma arising in the squamous temporal bone is particularly rare. Methods A 16‐year‐old male was seen with signs of sudden sensorineural hearing loss (SSNHL). After 1 week of SSNHL and new‐onset headache, imaging studies showed a mass that originated in the left squamous temporal bone with intracranial and extracranial extension. Histopathological study revealed that the mass was a Ewing sarcoma. Results The patient manifested the diagnostic EWSR1 mutation and was treated with adjuvant multidrug chemotherapy and focal radiotherapy after surgery according to the Children's Oncology Group interval compression arm of AEWS0031 with a regimen of vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide/etoposide. Conclusions This case showed an extremely uncommon location, as well as unusual symptoms of primary Ewing sarcoma.

show abstract

“…Small round cell neoplasms, including Ewing's sarcoma, primitive neuroectodermal tumor (PNET), Askin's tumor, PNET of the bone, and extraosseous Ewing's sarcoma, together constitute the peripheral primitive neuroectodermal (pPNET)/Ewing's sarcoma family of tumors [1]. Ewing sarcoma is the second most common bone tumor presenting in children.…”

Section: Introductionmentioning

confidence: 99%

“…Common sites of occurrence of extraosseous Ewing's sarcoma include soft tissues and bones of the lower extremity, paravertebral, and retroperitoneal regions [1]. Extraosseous Ewing's sarcoma rarely presents as a primary intracranial lesion.…”

Section: Introductionmentioning

confidence: 99%

An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing’s sarcoma

Jan

Khan

2018

Chin Neurosurg Jl

View full text Add to dashboard Cite

Background: Ewing's sarcoma family of tumors consists of small round cell neoplasms, inclusive of primitive neuroectodermal tumor (PNET), Askin's tumor, and PNET of the bone. Extraosseous Ewing's sarcoma occurs commonly at bones of lower extremities and paravertebral region of the spine. It rarely presents as a primary intracranial lesion. When intracranial, it can be misdiagnosed as central PNET (e.g., medulloblastoma, pinealoblastoma, or supratentorial PNET), other intracranial lesions, or even as an epidural hematoma. Case presentation: We report the case of a 20-year-old patient who presented to the emergency department with complaints of drowsiness, headache, and fever for 1 day. On initial computed tomography (CT) scan of the brain, a right temporal biconvex epidural lesion involving squamous-temporal bone with periosteal reaction was noted. The patient underwent urgent craniotomy, and a tumor was found and excised. Biopsy report confirmed Ewing's sarcoma. Conclusion: Ewing's sarcoma is a rare intracranial malignancy with only a few cases reported in literature. In a young patient with a biconvex epidural lesion, in the absence of trauma or ongoing infection, the possibility of Ewing's sarcoma should be considered as well.

show abstract

Primary extraosseous intracranial Ewing′s sarcoma: Case report and literature review

Cited by 29 publications

References 22 publications

Dural metastasis of Ewing′s sarcoma

Dural metastasis of Ewing′s sarcoma

Primary Ewing sarcoma of the squamous temporal bone with intracranial and extracranial extension: A rare cause of sudden sensorineural hearing loss

An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing’s sarcoma

Contact Info

Product

Resources

About