Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein

Abstract

The iliac vein is an extremely rare site for mesenchymal chondrosarcoma, and patients with primary extraskeletal mesenchymal chondrosarcoma arising from a vein always suffer a very poor prognosis. We report a case of a 45-year-old female who presented with a 5-month history of left leg edema in 2015. Contrast-enhanced computed tomography showed a large mass in the left iliac vein with scattered calcifications. Wide-margin resection was performed, and histopathologic and immunohistochemical analyses confirmed the presence of intraluminal mesenchymal chondrosarcoma with local invasion out of the vein wall. Due to poor patient compliance, postoperative neoadjuvant chemotherapy and radiotherapy were not started, and a bone scan performed 16 weeks postoperatively showed multiple bone metastases. The patient died on the twenty-fourth postoperative week.

Retroperitoneal mesenchymal chondrosarcoma with metastasis to iliac vein: A rare case report and review of the literature

“…The iliac vein is an extremely uncommon site for ESMC and patients with primary iliac vein mesenchymal chondrosarcoma have a very poor prognosis. 17 The femoral vein may also be the originating site for ESMC and it manifests with lower limb swelling and deep vein thrombosis. 18 Moreover, intravascular mesenchymal chondrosarcoma may also arise from the pulmonary veins.…”

“…ESMC can rarely involve the veins, with few cases being reported in the literature being as the primary site of the tumor. The iliac vein is an extremely uncommon site for ESMC and patients with primary iliac vein mesenchymal chondrosarcoma have a very poor prognosis 17 . The femoral vein may also be the originating site for ESMC and it manifests with lower limb swelling and deep vein thrombosis 18 .…”

Retroperitoneal mesenchymal chondrosarcoma with metastasis to iliac vein: A rare case report and review of the literature

“…ESMC can rarely involve the veins, with the cases being reported in the literature being as the primary site of the tumor. The iliac vein is an extremely uncommon site for ESMC and patients with primary iliac vein mesenchymal chondrosarcoma have a very poor prognosis [12]. The femoral vein may also be the originating site for ESMC and it manifests with lower limb swelling and deep vein thrombosis [13].…”

Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein

“…I have read with interest the case report by Zhang et al 1 on the primary extra skeletal mesenchymal chondrosarcoma (PEMC) arising from the iliac vein in a Chinese patient. 1 I presume that the following point ought to be considered in the studied patient.…”

“…I have read with interest the case report by Zhang et al 1 on the primary extra skeletal mesenchymal chondrosarcoma (PEMC) arising from the iliac vein in a Chinese patient. 1 I presume that the following point ought to be considered in the studied patient. It is obvious that apart from opportunistic infections, individuals infected with human immunodeficiency virus (HIV) are at an increased risk for various neoplastic disorders due to impaired humoral and cellular immunity.…”