Primary extraskeletal pleural osteosarcoma: a rare pleural identity

Copeland, Hannah; Makdisi, Peter B.; Duncan, Michael; Wozniak, Thomas; Makdisi, George

doi:10.21037/atm.2016.05.47

Cited by 2 publications

(2 citation statements)

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“…Table 2 summarises 10 cases of pleural osteosarcoma, including 8 previously reported cases and the present 2 cases (Shiota et al and Nishida et al ) 4–13. Median survival was 6.5 months (range 1.3–14.0) after biopsy or surgical operation in the present 10 mesothelioma cases, and 12 months (range 11 and 24 months) after surgical operation in the 10 thoracic osteosarcoma cases.…”

Section: Resultsmentioning

confidence: 70%

“…Extraskeletal osteosarcoma in the mediastinum, thoracic wall, lung and pleura is very rare. Indeed, only 10 cases of thoracic osteosarcoma have been previously reported,4–13 and their clinicopathological features remain to be fully elucidated. We examined such mesothelioma cases and pleural osteosarcomas, including eight cases in the literature, using clinicopathological and immunohistochemical methods, including those for a so-called mesothelioma marker as well as BRCA1-associated protein (BAP1), methylthioadenosine phosphorylase (MTAP) and monoclonal HEG1 homolog 1 (HEG1), and we also used fluorescence in situ hybridisation (FISH) to examine for homozygous deletion of p16.…”

Section: Introductionmentioning

confidence: 99%

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Malignant pleural mesothelioma with heterologous elements

et al. 2021

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AimsMalignant pleural mesothelioma with heterologous elements (such as osseous, cartilaginous or rhabdomyoblastic differentiation) is very rare. We tried to differentiate such mesothelioma cases from extraskeletal pleural osteosarcoma, which is very challenging.MethodsWe compared 10 malignant pleural mesotheliomas (three biphasic and seven sarcomatoid types) with two pleural osteosarcomas using clinicopathological and immunohistochemical methods, and also fluorescence in situ hybridisation (FISH) to examine for homozygous deletion of p16.ResultsThe median age was 72 years for mesotheliomas, and 69 years for osteosarcoma. For mesothelioma, eight cases were male and two were female. Growth was diffuse in all mesothelioma cases except case 10, where it was localised, as it was for the two osteosarcomas. Among mesothelioma cases, 80% displayed osteosarcomatous and 60% chondromatous elements, while 10% exhibited rhabdomyoblastic ones. Immunohistochemical labelling for calretinin and AE1/AE3 was present in 8/10 and 7/10 mesotheliomas, respectively, but in only one osteosarcoma. Loss of methylthioadenosine phosphorylase was seen in 5/7 mesotheliomas. FISH analysis revealed homozygous deletion of p16 in 5/8 mesothelioma and 2/2 osteosarcoma. Median survival was 6.5 months after biopsy or surgical operation in mesothelioma, and 12 months after operation in osteosarcoma.ConclusionsAlthough median survival was longer for osteosarcoma than for malignant mesothelioma, we could not differentiate mesothelioma from pleural osteosarcoma on the combined basis of clinicopathological and immunohistochemical data, and FISH analysis. However, diffuse growth was more frequent in mesothelioma than in osteosarcoma.

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Section: Resultsmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%