Primary gallbladder melanoma in dysplastic nevus syndrome: Report of case and literature review

Gligorijević, Jasmina; Živković, Vesna; Djordjević, Biljana; Dimov, Irena

doi:10.4318/tjg.2011.0278

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…Most anorectal melanomas are located within 6 cm of the anal rim . Gall bladder melanomas are most frequently located close to the neck of the gall bladder .…”

Section: Diagnosismentioning

confidence: 99%

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mikkelsen

Larsen

Buchwald

et al. 2016

APMIS

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Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people. The symptoms are not tumour-specific and are related to the organ system affected, and the disease is most often diagnosed at an advanced clinical stage. The diagnosis of a primary tumour is difficult, and metastatic cutaneous melanoma and choroidal melanoma must be excluded. Mutations in KIT are frequently found, while BRAF and NRAS mutations are rarely found - except in conjunctival melanomas that carry BRAF mutations. Mutations in the TERT promotor region are also found in mucosal melanomas. Complete surgical resection with free margins is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma).

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“…Most anorectal melanomas are located within 6 cm of the anal rim . Gall bladder melanomas are most frequently located close to the neck of the gall bladder .…”

Section: Diagnosismentioning

confidence: 99%

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mikkelsen

Larsen

Buchwald

et al. 2016

APMIS

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“…Regarding sex, 67.2% of the patients were male (39 patients), whereas 32.8% were female (19 patients). The ratio between men and women was 3:1, suggesting a male predominance in the reported MMG population 6–43 …”

Section: Resultsmentioning

confidence: 95%

Role of minimally invasive surgery in the treatment of gallbladder metastatic melanoma. A review of the literature and a case report

et al. 2022

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Background: Primary and secondary gallbladder melanomas are rare, and only 58 cases have been reported in scientific literature to date. This paper aimed to explore the role of minimally invasive surgery in the management of gallbladder metastatic melanomas.Case: Herein, we present the case of a 68-year-old man with metastatic gallbladder melanoma who was treated with laparoscopic cholecystectomy. Our case management was then compared with that of other cases reported in the literature. Conclusion:Currently, metastatic melanomas can be considered as a potentially curable disease. Palliation of symptoms and fast recovery following minimally invasive procedures could be beneficial for these patients. Particularly, laparoscopic procedures appear to prolong the survival of gallbladder melanoma patients.

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“…Ultrasonography, the cheapest method, is important to help distinguish between benign and malignant polyps; 94% of the former are less than 1 cm in diameter, whereas 88% of the latter are more than 1 cm. [ 16 ] In 2011, Gligorijevic et al [ 17 ] reviewed previous 31 cases of primary gallbladder melanoma, and found that the size of the tumor ranges from 1.5 to 7.5 cm in diameter. CT or magnetic resonance imaging is valuable, especially in detecting metastatic disease like our case.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the gallbladder with multiple metastases

Wang

Su²,

Ma³

et al. 2017

Medicine

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Rational:Primary malignant melanoma of the gallbladder is an extremely rare tumor, with fewer than 40 cases reported in the literature worldwide. The majority of patients presented as a solitary lesion in the gallbladder. To our knowledge, only one case of primary malignant melanoma of the gallbladder with multiple metastases has been reported, which involved the stomach, duodenum, pancreas, jejunum and a mesenteric lymph node.Patient concerns:We report a case of primary malignant melanoma of the gallbladder with metastases to the duodenal bulb, right adrenal and a celiac lymph node.Diagnoses:Primary malignant melanoma of the gallbladder with multiple metastases.Interventions:Gastrojejunostomy, cholecystectomy, and biopsy of the three metastatic lesions were performed. Histopathologic examination revealed melanin pigments were within the tumor cells of the four lesions, however, junctional activity was noted only in the gallbladder, supporting that the gallbladder was the primary site. No pigmented lesions were detected on the skin or eyes. The postoperative recovery was uneventful, and subsequently, chemotherapy with paclitaxel and carboplatin was administered.Outcomes:The patient survived for 16 months due to tumor. progression.Lessons:The current case was unique due to the adrenal involvement. For patients with multiple metastases of malignant melanoma, gallbladder origin should be considered in the differential diagnosis from cutaneous origin.

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Primary gallbladder melanoma in dysplastic nevus syndrome: Report of case and literature review

Cited by 12 publications

References 23 publications

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Role of minimally invasive surgery in the treatment of gallbladder metastatic melanoma. A review of the literature and a case report

Primary malignant melanoma of the gallbladder with multiple metastases

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