Primary gastric lymphoma

Al-Akwaa, Ahmad M; Siddiqui, Neelam; Al-Mofleh, Ibrahim

doi:10.3748/wjg.v10.i1.5

Cited by 102 publications

(89 citation statements)

References 88 publications

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“…Physical exploration in patients with gastric MALT lymphoma does not usually reveal any alterations (1)(2)(3)(4)(5)15), as was the case in most of our patients. Nonetheless, in high-grade lymphomas, clinical manifestations may be more evident.…”

Section: Discussionsupporting

confidence: 60%

“…In our patients the most common presentation symptom was dyspepsia (76%). In patients with advancedstage lymphoma, anemia or a constitutional syndrome was present in 88% of our patients, these symptoms raising the possible diagnosis of gastric carcinoma (1)(2)(3)(4)(5)12,13). Finally, gastric MALT lymphoma may present with upper gastrointestinal bleeding in 20-30% of cases (1)(2)(3)(4)(5)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 65%

“…However, primary gastric lymphoma is the most common extranodal lymphoma (1)(2)(3)(4)(5). Histological features of gastric low-grade lymphomas closely resemble mucosa-associated lymphoid tissue (MALT) (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies showed that the prevalence of infection depends on the lymphoma's histological grade or the diagnostic method used, among others (8). A knowledge of the true prevalence of H. pylori in patients with MALT lymphoma is clinically relevant, as the detection of this organism will be followed by adequate eradication treatment, with consequent tumor regression in a high number of cases (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gisbert

Aguado

Luna

et al. 2006

Rev. esp. enferm. dig.

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Objective: to perform a retrospective review of the clinical characteristics and prevalence of H. pylori infection in patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years.Methods: patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years were retrospectively included. Demographic, clinic, analytic, endoscopic, and histological variables were reviewed. The extension study, the staging classification, and the presence of H. pylori infection were assessed.Results: thirty-seven patients with gastric MALT lymphoma were identified. Mean age was 61 years, with 62% of males. The most common presentation symptom was dyspepsia (76%), followed by digestive bleeding (11%) and constitutional syndrome (8%). At endoscopy, erosive lesions were identified in 41%, and proliferative or exophytic lesions in 43%. Most lymphomas were classified as low-grade (68%). The stage distribution was EI for 56%, EII for 13%, EIII for 3%, and EIV for 28%. The prevalence of H. pylori infection (histology in all cases, rapid urease test in 19%, and 13 C-urea breath test in 24%) was 46%. When only lowgrade lymphomas in stage EI were considered, H. pylori prevalence increased to 55%. When H. pylori infection was evaluated by 13 C-urea breath testing (in addition to histology), the prevalence of H. pylori infection increased to 78%.Conclusions: it is probable that the reduced H. pylori prevalence found in some studies, as in ours, could be explained by false-negative results obtained when only one diagnostic method was used. Therefore, at least two (invasive) diagnostic methods should be performed. Furthermore, the performance of a non-invasive diagnostic method (such as a 13 C-urea breath test) before the exclusion of H. pylori infection should be considered.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gisbert

Aguado

Luna

et al. 2006

Rev. esp. enferm. dig.

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“…H pylori infection can lead to chronic gastritis, peptic ulcer disease, and is also a risk factor for g astric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma [1][2][3][4] . More than 50% of the human population worldwide are infected with H pylori.…”

Section: Introductionmentioning

confidence: 99%

Construction of recombinant attenuated Salmonella typhimurium DNA vaccine expressingH pyloriureB and IL-2

Li²,

Du³

et al. 2007

WJG

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with the sequence of mouse IL-2 in gene bank. It was confirmed by PCR and restriction enzyme digestion that H pylori ureB and mouse IL-2 genes were inserted into the eukaryotic expression vector pIRES. The experiments in vitro showed that stable recombinant live attenuated Salmonella typhimurium DNA vaccine carrying ureB and IL-2 genes was successfully constructed and the specific strips of UreB and IL-2 expressed by recombinant plasmids were detected through Western blot. Study in vivo showed that the positive rate of rapid urease test of the immunized group including ureB and ureB-IL-2 was 37.5% and 12.5% respectively, and was significantly lower than that (100%) in the control group (P < 0.01). CONCLUSION: INTRODUCTIONH pylori infection can lead to chronic gastritis, peptic ulcer disease, and is also a risk factor for g astric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma [1][2][3][4] . More than 50% of the human population worldwide are infected with H pylori. About 10%-20% of all the patients have severe diseases such as gastric or duodenal ulcer and gastric cancer. The current therapy, based on the use of proton-pump inhibitor and antibiotics [5][6][7] , is efficacious but faces potential problems like patient compliance, increasingly reported antibiotic resistance, and side effects such as abdominal pain, nausea, diarrhea [8] . METHODS: H pylori u re B a n d m o u s e I L-2 g e n e fragments were amplified by polymerase chain reaction (PCR) and cloned into pUCmT vector. DNA sequence of the amplified ureB and IL-2 genes was assayed, then cloned into the eukaryotic expression vector pIRES through enzyme digestion and ligation reactions resulting in pIRES-ureB and pIRES-ureB-IL-2. The recombinant plasmids were used to transform competent E. coli DH5α, and the positive clones were screened by PCR and restriction enzyme digestion. Then, the recombinant pIRES-ureB and pIRES-ureB-IL-2 were used to transform LB5000 and the recombinant plasmids extracted from LB5000 were finally introduced into the final host SL7207.After that, recombinant strains were grown in vitro repeatedly. In order to detect the immunogenicity of the vaccine in vitro , pIRES-ureB and pIRES-ureB-IL-2 were transfected to COS-7 cells using Lipofectamine TM 2000, the immunogenicity of expressed UreB and IL-2 proteins was assayed with SDS-PAGE and Western blot. C57BL/6 mice were orally immunized with 1 × 10 8 recombinant attenuated Salmonella typhimurium DNA vaccine. Four weeks after vaccination, mice were challenged with 1 × 10 7 CFU of live H pylori SS1. Mice were sacrificed and the stomach was isolated for examination of H pylori 4 wk post-challenge. RESULTS:The 1700 base pair ureB gene fragment amplified from the genomic DNA was consistent with the sequence of H pylori ureB by sequence analysis.The amplified 510 base pair fragment was consistent

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The epidemiology and prognosis of patients with primary gastric T‐cell lymphoma in the SEER program

et al. 2022

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Background Primary gastric T‐cell lymphoma (PG‐TCL) is a rare hematological malignancy with few data reported. The objective of this study is to investigate the epidemiology, clinical characteristics, and survivals of PG‐TCL. Methods Totally, 164 patients with PG‐TCL from 1975 to 2016 extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database were analyzed. Kaplan–Meier method was applied to plot overall survival (OS) and cancer‐specific survival (CSS). The prognostic factors of OS and CSS were explored by Cox proportional hazard regression. Nomograms were constructed to predict survival possibilities. Results The age‐adjusted incidence rate of PG‐TCL was 0.0091 per 100,000 person‐years and increased with age. The median age at onset was 65 years old with male predominance. The major histological type was peripheral T‐cell lymphoma, NOS (63.4%). The 1‐, 2‐, and 5‐year OS were 45.5%, 34.7%, and 23.5%, respectively while the 1‐, 2‐, and 5‐year CSS were 47.4%, 37.3%, and 29.6%, respectively. Multivariate Cox analysis demonstrated that age at diagnosis, use of chemotherapy, and radiotherapy were the independent prognostic factors for OS. Chemotherapy combined with radiotherapy could significantly improve patients' OS compared with chemotherapy alone. Moreover, age at diagnosis and use of chemotherapy were also the independent prognostic factors for CSS. Nomograms for PG‐TCL were developed to predict 1‐, 2‐, and 5‐year OS possibilities. The predictability of nomograms was verified by high concordance index and good agreement with the predicted value in calibration plots. Conclusion PG‐TCL is a rare neoplasm with low incidence. Patients with PG‐TCL generally exhibited poor prognosis. Use of chemotherapy plus radiotherapy was associated with favorable OS.

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Primary gastric lymphoma

Cited by 102 publications

References 88 publications

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Construction of recombinant attenuated Salmonella typhimurium DNA vaccine expressingH pyloriureB and IL-2

The epidemiology and prognosis of patients with primary gastric T‐cell lymphoma in the SEER program

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