Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature

Kairi-Vassilatou, E; Papakonstantinou, Katerina; Grapsa, Dimitra; Kondi-Paphiti, A.; Hasiakos, D

doi:10.1111/j.1525-1438.2006.00852.x

Cited by 29 publications

(18 citation statements)

References 9 publications

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“…Primary extrauterine choriocarcinoma is rare and most reported cases have occurred in the uterine cervix. 2 It is thought to arise along the path of migration of germ cells to gonads, or de-differentiated from another histological type. 3 Our case was very unusual as it occurred in the vagina.…”

Section: Discussionmentioning

confidence: 99%

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Wong¹,

Fung²,

Yung³

2016

Hong Kong Med J

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A 33-year-old nulligravid Filipino woman was admitted to the gynaecology ward of Princess Margaret Hospital in April 2014, with lower abdominal pain and recurrent retention of urine. Her pregnancy test was positive. Per-vaginal examination revealed a 4-cm firm, fixed, and wide-based vaginal mass with smooth wall over the upper anterior vagina. Bedside transabdominal ultrasonography confirmed a 4.5-cm solid mass in the anterior vagina and a 3. <5.0 IU/L for non-pregnant women), and repeated checking 3 days later was 253 957 IU/L. Alphafetoprotein, carcinoembryonic antigen, and Ca-125 were negative. A urologist was consulted and the patient underwent flexible cystoscopy that revealed indentation of the urinary bladder by an external mass. Mild erythematous changes were visualised at the right urinary bladder base. Biopsy revealed inflammation but no malignant cells.Magnetic resonance imaging (MRI) of the pelvis revealed a 4.8 cm x 5.2 cm x 4 cm (craniocaudal x anteroposterior x transverse) mass located at the anterior aspect of the vagina. It was hypointense with a faint hyperintense rim on T1-weighted images (Fig 1a) and heterogeneously hyperintense CASE REPORT

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Section: Discussionmentioning

confidence: 99%

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Wong¹,

Fung²,

Yung³

2016

Hong Kong Med J

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show abstract

“…Extrauterine choriocarcinoma is a rare entity. Only a few cases have been reported in the literature up to now, and most of these cases were located in the uterine cervix [1-4]. Other extrauterine locations have also been reported, including the ovary [5,6], Fallopian tube [7], vagina [8], vulva [9] and gut [10].…”

Section: Introductionmentioning

confidence: 99%

Caesarean scar choriocarcinoma: a case report and review of the literature

Qian

Zhu

2014

Eur J Med Res

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ObjectiveTo report the clinical characteristics, pathologic findings and treatments of a patient with a Caesarean scar choriocarcinoma.Patient historyA 22-year-old woman had a diagnosis of primary gestational choriocarcinoma in a uterine Caesarean scar misdiagnosed as a normal Caesarean scar pregnancy. The patient underwent selective uterine artery embolization coupled with methotrexate arterial injection, along with dilatation and curettage of the uterine Caesarean scar. Finally, she received eight courses of multiagent chemotherapy. The reproductive function of the patient was preserved.ConclusionsPrimary gestational choriocarcinoma out of the uterine corpus is a rare disease. A Caesarean scar choriocarcinoma is an extremely unusual example of this entity because of its unique position. To the best of our knowledge, this is the first report of this phenomenon. Our experience and a literature review suggest that a clinical diagnosis of a primary gestational choriocarcinoma of the uterine Caesarean scar is difficult to make, and uterine artery embolization is beneficial to prevent massive bleeding before curettage.

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“…1 GC accompanied by massive ascites accumulation is rare, and treatment of gestational choriocarcinoma and massive ascites by CRS post HIPC guided by ultrasound have not been reported in the literature to our knowledge.…”

Section: Discussionmentioning

confidence: 92%

Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery

Ba¹,

Long²,

Wu³

2013

Pak J Med Sci

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A 33-year-old woman with very poor health status was admitted to our hospital because she had experienced increasing abdominal distention for three months, CT examination showed a right ovarian tumor together with massive abdominal and pelvic fluid. The patient was first treated by continuous circulatory hypothermic intraperitoneal perfusion chemotherapy (HIPC) guided by B-mode ultrasound, followed by cytoreductive surgery (CRS) after her ascites was controlled and her health condition improved. She was diagnosed with gestational choriocarcinoma (GC) based on the pathological examination of the hysterectomy specimen. She is still alive with very good health today. We think it may be a good choice for a patient in very poor health with GC accompanied by massive ascites to perform HIPC guided by B-mode ultrasound firstly, followed by CRS when the ascites has relieved and the patient’s health has improved.

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Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature

Cited by 29 publications

References 9 publications

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings

Caesarean scar choriocarcinoma: a case report and review of the literature

Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery

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