Primary hepatic gastrointestinal stromal tumor: A case series

Primary Hepatic Extra-gastrointestinal Stromal Tumors: Molecular Pathogenesis, Immunohistopathology, and Treatment

“…On MRI, PHGIST usually appears as a round cyst-like solid mass that can be lobulated with bright or fuzzy borders and a thick pseudocapsule with central necrosis and cysts. 4 However, Mu et al 16 reported that the capsule or pseudocapsule of PHGIST tends to enhance unevenly during the arterial phase. Ring augmentation paired with cystic alterations can readily be mistaken for hepatoseptoma, especially when minor septations on the border resemble abscess chambers.…”

“…PHGIST enhancement in the venous phase is lower than or comparable to that in normal liver tissues. Mu et al 16 reported a biopsy-confirmed PHGIST patient had a mass with hypointensity on the T1-weighted pictures and hyperintensity on the T2-weighted images with limited diffusion on contrast-enhanced magnetic resonance imaging (CEMRI) and central necrosis and capsule ring enhancement. Thus, CEMRI features including arterial phase hyperenhancement, capsule enhancement, washout, and bleeding on imaging, can result in confusion with HCC.…”

“… 4 However, Mu et al . 16 reported that the capsule or pseudocapsule of PHGIST tends to enhance unevenly during the arterial phase. Ring augmentation paired with cystic alterations can readily be mistaken for hepatoseptoma, especially when minor septations on the border resemble abscess chambers.…”

Primary Hepatic Gastrointestinal Stromal Tumor on 18F-FDG PET/CT Images

“…Similar to these hepatic malignancies, the degree of enhancement of primary hepatic gastrointestinal stromal tumor is not significantly higher than the liver in the arterial phase, whereas the degree of enhancement is slightly lower than normal liver tissue in the delay phase, indicating that it is also nourished by hepatic arteries. [10][11][12] Different from hepatocellular carcinoma, high levels of serum α-fetoprotein are rarely seen in primary hepatic gastrointestinal stromal tumors. 13 On the other hand, the exclusion of metastatic tumors is crucial for the diagnosis of primary hepatic stromal tumors.…”

“…We report a 56-year-old man with primary hepatic gastrointestinal stromal tumor demonstrating multiple heterogeneous lesions with intense FDG uptake in the liver on PET/CT mimicking hepatocellular carcinoma or sarcoma with necrosis. Similar to these hepatic malignancies, the degree of enhancement of primary hepatic gastrointestinal stromal tumor is not significantly higher than the liver in the arterial phase, whereas the degree of enhancement is slightly lower than normal liver tissue in the delay phase, indicating that it is also nourished by hepatic arteries 10–12 . Different from hepatocellular carcinoma, high levels of serum α-fetoprotein are rarely seen in primary hepatic gastrointestinal stromal tumors 13 .…”