Primary Hepatic Leiomyosarcoma—a Rare Neoplasm in an Adult Patient with AIDS: Second Case Report and Literature Review

Metta, Humberto; Corti, Marcelo; Trione, Norberto; Masini, Daniela; Monestes, Jorge; Rizzolo, Mariana; Carballido, Marcela

doi:10.1007/s12029-013-9525-3

Cited by 9 publications

(11 citation statements)

References 12 publications

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“…The underlying pathogenetic mechanisms have not been identified yet. However, there are some cases of primary hepatic leiomyosarcoma in immunosuppressed patients, two of whom had acquired immunodeficiency syndrome (32,33). One of the patients with acquired immunodeficiency syndrome also had infection from Epstein-Barr virus (32).…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonography usually shows a hypoechoic mass (15,17,19,29,30,33,37) or a mass with heterogeneous echogenicity (17,22,27,30,31,37). Computed tomography usually reveals a hypodense (12, 17, 19, 21, 23, 27-33, 37, 39) and often heterogeneous mass (17,21,23,31,34) with inhomogeneous and often peripheral enhancement after administration of intravenous contrast (15,17,19,23,(27)(28)(29)(30)(31)(32)(33)40), which may show regions of cystic degeneration (27,28,31,32). Magnetic resonance imaging displays on the other hand a usually heterogeneous mass that is hypointense in T1-weighted images and hyperintense in T2-weighted images (16,19,21,37,39,40).…”

Section: Discussionmentioning

confidence: 99%

“…Histological examination of primary hepatic leiomyosarcomas shows spindle-shaped cells with fascicular arrangement (4, 8, 10-12, 15-17, 19, 21, 22, 26-34, 36-38, 40). Immunohistochemistry reveals expression of smooth muscle actin (13, 15, 18, 19, 21, 22, 27-33, 36-38, 40), desmin (13,15,19,21,22,(27)(28)(29)(30)(31)(32)(33)(34)(36)(37)(38) and vimentin (15, 17, 19, 22, 27-29, 31, 33, 37, 38, 40), whereas cytokeratins (22, 27-33, 37, 38), neuron-specific enolase (27)(28)(29)32) and S-100 protein (19, 21, 27-34, 37, 38, 40) are not expressed.…”

Section: Discussionmentioning

confidence: 99%

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Primary Hepatic Leiomyosarcoma: a Case Report and Review of the Literature

Feretis

Kostakis

Damaskos

et al. 2018

Acta Med. (Hradec Kralove, Czech Repub.)

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A B ST R AC T Background/Aim: Primary hepatic leiomyosarcoma is an extremely rare type of liver sarcoma with relatively poor prognosis, with about 50 cases having been reported in the literature. Potential origins of this tumor in the liver are the smooth muscle cells in the round ligament, intrahepatic blood vessels and intrahepatic bile ducts. There is no apparent sex predilection and there is a wide age range. The clinical presentation is not specific and the diagnosis depends on the expression of markers such as smooth muscle actin, desmin and vimentin by tumor cells. Patients and Methods: Herein, we present a case of a bulky primary hepatic leiomyosarcoma in a 68-year-old female patient. The patient underwent resection of the exophytic mass en block with the hepatic segments III and IVB. Conclusion: Surgical resection is the most effective among the treatment options. K E Y WO R D S hepatic; liver; leiomyosarcoma, primary

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Hepatic Leiomyosarcoma: a Case Report and Review of the Literature

Feretis

Kostakis

Damaskos

et al. 2018

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Hepatic leiomyosarcoma patients show common symptoms of abdominal pain, weight loss, appetite loss, and weakness, [3–8] and uncommon symptoms of fever, abdominal distension, back pain, and jaundice. [4,5,9,10] Hepatic leiomyosarcoma originating from the hepatic vein may lead to the Budd–Chiari syndrome owing to the obvious space-occupying effect of large tumors. [6] Nonetheless, for small tumors, hepatic leiomyosarcomas may be asymptomatic in clinic.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic leiomyosarcoma presenting as a thick-walled cystic mass resembling a liver abscess

Liu

Liang

2018

Medicine

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Rationale:Hepatic leiomyosarcoma is a rare malignant tumor, and in rare instances, its combination with fever may lead to misdiagnosis of liver abscess. In our case, the presence of the tumor was considered by the presence of blood vessels through the observation of hepatic tumor wall.Patient concerns:A 38-year-old woman who had been diagnosed with a liver abscess in a local hospital consulted our institution by complaining left upper quadrant pain and fever. The diagnosis was questioned in our workup, since no obvious inflammatory marker was found in the circulation, and contrast-enhanced computed tomography revealed a huge thick-walled mass in the right liver with multiple tortuous vessels within the wall.Diagnosis:Imaging revealed a neoplastic lesion rather than liver abscess. The enhancement of the solid tumor tissues was reduced during the portal phase and delayed phase, which was consistent with a wash-out enhancement. The histopathologic and immunohistochemical results confirmed the diagnosis was primary hepatic leiomyosarcoma. A pulmonary nodule during the postoperative follow-up was diagnosed as metastatic leiomyosarcoma tumor through surgery.Interventions:A right hepatectomy was performed to cure the hepatic mass. In the follow-up, a metastatic tumor in the lung was resected, followed by chemotherapy.Outcomes:Lung metastasis and liver recurrence occurred at 25 and 39 months after liver surgery, respectively. Then the patient was lost to follow-up.Lessons:Leiomyosarcoma is associated with a dismal prognosis, but outcomes for these patients may be improved by the combined surgical resection and chemotherapy.

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“…Previous reports have described the development of PHL in patients with Hodgkin's lymphoma [6,7], gastric nonHodgkin's lymphoma [8], hereditary retinoblastoma [9], immunosuppression due to renal or liver transplantation [10,11], von Recklinghausen's disease [12], cirrhosis due to hepatitis C virus [13], Behcet's disease [14], acquired immunodeficiency syndrome [15][16][17][18], EBV [11,17], use of Thorotrast [19], and multiple cancers [20].…”

Section: Discussionmentioning

confidence: 99%