Primary high grade testicular leiomyosarcoma: A rare malignancy in a young male

Siraj, Fouzia; Sharma, Swati; Bhushan, Chandra; Vasudeva, Pawan

doi:10.5152/tud.2017.15821

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…What's more, most patients enrolled in our study had normal AFP, hCG, and LDH. This is consistent with previously reported cases, including but not limited to a 27-year-old male with highgrade primary testicular leimyosarcoma reported by Fouzia Siraj et al (5) and a 51-year-old patient with primary testicular sarcoma reported by Allaway M. et al (6). We did not find that these serum tumor markers had a statistically significant impact on CSM and DM in TS patients.…”

Section: Discussionsupporting

confidence: 93%

“…The management decision of TS should not be made on the basis of current guidelines for testicular tumors (which was mainly on TGCTs). Since TS is particularly rare, studies about this cancer are limited, and most of them are case reports or case reviews (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). To our knowledge, this is the first cohort study based on a relatively large amount of TS patients, reporting clinical characteristics and factors that may affect the prognosis of TS patients.…”

Section: Discussionmentioning

confidence: 99%

“…As far as we know, a number of cases of TS have been reported in the previous literature ( 5 – 18 ), but no cohort study has been published. This study aimed to identify the clinical characteristics and factors that may affect the prognosis of TS patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Prognostic Factors of Testicular Sarcoma: A Population-Based Study

et al. 2021

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ObjectivesTo study clinical characteristics and factors that may affect the prognosis of testicular sarcoma patients.Patients and MethodsIn the Surveillance Epidemiology and End Results database (2006–2016), people with testicular sarcoma were enrolled in our research. Multivariable Cox proportional hazard model and Multivariable Logistic regression model were used to compare the impact of different factors on cancer-specific survival, localized metastasis, and distant metastasis.ResultsThis research was based on the registry information of 158 testicular sarcoma patients. All patients with a median age of 17.00 (1.00–93.00) years were pathologically diagnosed with orchiectomy or needle biopsy specimens. Patients with Grade I, II, III, and IV testicular sarcoma accounted for 34.29% (n = 24), 10.10% (n = 7), 22.86% (n = 16), and 32.86% (n = 23) of all patients, respectively. There were 42 (30.43%), 53 (38.41%), 15 (10.87%), 20 (14.49%), 5 (3.62%), 3 (2.17%) patients with Tis, T1, T2, T3, T4, and >T4 (the invasion degree exceeded the staging system of testicular cancer) disease respectively. Among all included patients, localized metastasis occurred in 31 (20.13%) patients, distant metastasis was found in 28 (18.18%) patients during observation, and 61.69% (n = 95) had no metastasis. Thirty-two (20.25%) patients died of this cancer. According to our study, patients with distant metastasis [OR = 17.86, 95% CI (4.63–68.84), p < 0.0001] and T3 disease [OR = 4.13, 95% CI (1.10–15.53), p = 0.0359] were more likely to die of this cancer. Patients with advanced T stage were more likely to occur distant metastasis, [OR = 13.91, 95% CI (1.80–107.54), p = 0.0116] for T3 and [OR = 16.36, 95% CI (1.36–196.21), p = 0.0275] for T4.ConclusionsAccording to our research, factors including metastasis and higher T stage were significantly related with poorer prognosis of testicular sarcoma. Higher T stage was also found to be a risk factor of distant metastasis. The recognization of these poor prognostic factors may allow physicians to make comprehensive and appropriate management decision for testicular sarcoma patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics and Prognostic Factors of Testicular Sarcoma: A Population-Based Study

et al. 2021

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“…Reported cases with primary leiomyosarcoma in testis had the average age of 50 years which is compatible with our case. According to reported cases, young patients essentially had risk factors such as anabolic steroid use for long time, other germ cell tumors in testis, chronic inflammation in testis and local radiotherapy for previous leukemia (6). Most reported cases have been in small series in relationship with germ cell tumors (7).…”

Section: Discussionmentioning

confidence: 99%

Primary Testis Leiomyosarcoma: A Case Report

Nazar¹,

Shabanzadeh²,

Moghadam-Ahmadi³

et al. 2021

Iran J Pathol

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Scan to discover onlinePrimary leiomyosarcoma in testis is an uncommon tumor with few cases reported. It generally develops after radiotherapy or long-term taking anabolic steroid medication. We report a 53-year-old male patient with primary testis leiomyosarcoma who presented with painless testicular enlargement without any known predisposing factors. Ultrasound revealed a large heterogeneous left testicular solid lesion. Alpha-fetoprotein (AFP) and beta-human chorionic gonadotrophin (beta-HCG) levels in serum were normal. Left radical orchidectomy following with histology assessment established a diagnosis of primary leiomyosarcoma of testis. No data of cancer metastasis was established. The patient didn't receive any adjuvant therapy. There wasn't any evidence of recurrence after 1 year follow-up. Leiomyosarcoma must be one of the differential diagnoses of seronegative tumors in testis. The motivation for this paper is the extreme infrequency of the situation and the differential diagnosis by all expansive inguinoscrotal tumors.

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“…Leiomyosarcoma of the testis is a rare tumor [ 3 ], a review of the literature allowed us to identify 30 cases worldwide, the first one was reported by Yachia.D and Auslaender in 1989 [ 4 ]. The latest was reported by Siraj and al in 2018 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Testicular leiomyosarcoma: A case report and literature review

Hussein¹,

Dergamoun²,

Hachem³

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Leiomyosarcoma is a malignant mesenchymal tumor derived from the smooth muscle, it represents approximately 7% of all soft tissue sarcomas. Male genitourinary leiomyosarcomas are rare (Abdullazade et al., 2013 [ 1 ]). Primary testicular leiomyosarcoma is an exceptional entity with only 30 cases reported in the literature (Giridhar et al., 2011). Due to its rarity, additional studies are necessary to better define the optimal therapeutic management. Case presentation We report a case of a 42-years-old male diagnosed in the urology department A of the University Hospital Ibn Sina in Rabat who complains of testicular swelling. The anatomopathological examination and immunohistochemical study revealed a leiomyosarcoma therefore, a radical inguinal orchiectomy with a primary ligation of the spermatic cord was performed for diagnostic and therapeutic purposes. The assessment of extension did not reveal any lymph node location or secondary appearance thus the decision of the multidisciplinary meeting opted for regular cancer check-ups without adjuvant treatment. Discussion The actual etiology of testicular leiomyosarcoma is still unknown added to its clinical presentation and radiological results that are non-specific. Conclusion Leiomyosarcoma of the testis is a very rare tumor and its clinical and radiological presentation remains similar to other testicular malignancies.

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Primary high grade testicular leiomyosarcoma: A rare malignancy in a young male

Cited by 6 publications

References 9 publications

Clinical Characteristics and Prognostic Factors of Testicular Sarcoma: A Population-Based Study

Clinical Characteristics and Prognostic Factors of Testicular Sarcoma: A Population-Based Study

Primary Testis Leiomyosarcoma: A Case Report

Testicular leiomyosarcoma: A case report and literature review

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