Primary hyperparathyroidism associated with a giant cell tumor: One case in the distal radius

Ouzaa, Mohamed Reda; Bennis, A.; Iken, M.; Abouzzahir, A.; Boussouga, M.; Jaafar, A.

doi:10.1016/j.main.2015.06.005

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…GCT and HPT are usually not encountered at the same time. 14 The exception is that Ouzaa et al 15 described the case of a 66-year-old woman with osteolytic lesions in the distal radius and PHPT; thus, she was diagnosed with brown tumors. After 1-year follow-up, her osteolytic lesions had not recovered but rather gotten worse, of which the biopsy was suggestive of GCT.…”

Section: Discussionmentioning

confidence: 99%

Primary hyperparathyroidism-induced brown tumors caused by parathyroid carcinoma: a case report and literature review

Zhou

Shi

et al. 2022

J Int Med Res

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Brown tumors represent a benign disease that is induced by primary or secondary hyperparathyroidism, with the pathological feature of osteitis fibrosa cystica. Primary hyperparathyroidism caused by parathyroid carcinoma resulting in brown tumors is extremely rare. Herein, we report the case of a 60-year-old male patient who was admitted for giant cell tumors of the bone with local pain and limited movement of the left knee joint. With early detection of multifocal osteolytic bone lesions, hyperparathyroidism (parathyroid hormone: 2365.00 pg/mL), and parathyroid cancer, the diagnosis of brown tumors was confirmed without any unnecessary or harmful interventions. Thereafter, he underwent parathyroidectomy, from which postoperative pathology confirmed parathyroid carcinoma, and total knee arthroplasty to restore movement of the knee joint. Seven months after surgery, the left knee joint had good range of movement. This case emphasizes that detecting patients’ parathyroid hormone levels should not be neglected when diagnosing multifocal osteolytic bone lesions. A comprehensive analysis combining clinical symptoms, imaging, and laboratory tests is conducive to accurate disease assessments and avoiding unnecessary or even survival-impairing surgery. However, when the tumor involves a large joint or seriously affects joint movement, surgery may be worth considering.

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Section: Discussionmentioning

confidence: 99%

Primary hyperparathyroidism-induced brown tumors caused by parathyroid carcinoma: a case report and literature review

Zhou

Shi

et al. 2022

J Int Med Res

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“…There have also been reports describing the concomitant presence of a GCT with BTs of hyperparathyroidism [ 12 , 25 ]. In such cases a GCT must be suspected when no regression of the bony lesion is observed after appropriate treatment of the hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Ouzaa et al . [ 25 ] described a honeycomb osteolytic lesion in the distal radius in a 66-year-old woman, diagnosed with PHPT. At 1-year follow-up she had worsening clinical symptoms and increased osteolyses on X-rays.…”

Section: Discussionmentioning

confidence: 99%

Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report

et al. 2018

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BackgroundBrown tumors represent a rare clinical manifestation reported in approximately 3% of patients with primary hyperparathyroidism and correspond to radiologically osteolytic lesions with well-defined borders in different parts of the skeleton.Case presentationWe report the case of a 53-year-old white man who presented to our hospital with osteolytic lesions of his distal ulna and radius, causing pain and swelling of 2-month duration. A subsequent biopsy revealed histological features consistent with giant cell tumor and a complete resection of his distal ulna was followed, along with curettage and cementoplasty of the distal radial metaphysis. Two weeks later, he was re-admitted with diffuse musculoskeletal soreness, anorexia, constipation, nausea, and localized abdominal pain and multiple osteolytic lesions on plain radiographs. A histopathological examination of the ulna and radius specimens showed similar findings and, given the multifocality, brown tumors related to primary or secondary hyperparathyroidism was included in the differential diagnosis. A laboratory examination showed high total serum calcium (14.5 mg/dl) and low serum phosphorus and 25-hydroxyvitamin D levels. Primary hyperparathyroidism was suspected and confirmed by the elevated parathyroid hormone levels of 1453 pg/mL. At radiological work-up, using computed tomography, ultrasonography, and parathyroid subtraction technetium-99m sestamibi scintigraphy, a 4.5 × 2.5 × 3.2 cm mass emanating from the right lobe of his thyroid gland was detected, displaying extensive uptake in the right lower parathyroid gland. After appropriate medical support including hyperhydration and high doses of diuretics and diphosphonates, his laboratory profile normalized and he underwent total thyroidectomy with removal of the parathyroid glands. Our patient is now recovering 12 months after surgery, with normal values of serum parathyroid hormone and calcium levels. The lytic bone lesions have almost disappeared and no other additional orthopedic intervention was necessary.ConclusionsThe present case report emphasizes the need of inclusion of brown tumors in the differential diagnosis of multifocal osteolytic bone lesions, in order to avoid harmful surgical interventions. Laboratory testing of serum phosphate, calcium levels, and parathyroid hormone levels should always be included in the routine survey of patients with multifocal osteolytic lesions.

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“…Dentro de los hallazgos histopatológicos que ayudan a diferenciarlos son: la morfología y los núcleos de las células mononucleares en el TCG que son diferentes de los fibroblastos en TP; las células gigantes tienden a distribuirse uniformemente en el TCG, mientras que en TP suelen estar dispuestas en grupos, además, en el TP se pueden encontrar glóbulos rojos extravasados, macrófagos cargados de hemosiderina y células gigantes multinucleadas dispersas que se agrupan alrededor de las áreas de hemorragia y necrosis 2,20 . Adicionalmente cabe destacar que se han reportado casos de TCG en paciente con HPT 2,21 .…”

Section: B Aunclassified

Tumor de células gigantes vs. tumor pardo del hiperparatiroidismo. Reporte de caso

López-Delgado,

Martínez-Pantoja,

Bastante-Navarro

et al. 2024

GAMO

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Primary hyperparathyroidism associated with a giant cell tumor: One case in the distal radius

Cited by 5 publications

References 8 publications

Primary hyperparathyroidism-induced brown tumors caused by parathyroid carcinoma: a case report and literature review

Primary hyperparathyroidism-induced brown tumors caused by parathyroid carcinoma: a case report and literature review

Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report

Tumor de células gigantes vs. tumor pardo del hiperparatiroidismo. Reporte de caso

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