Primary hyperparathyroidism in pregnancy

Perin, Elena; Cacciaguerra, Giovanna; Lapenna, Roberta; Catena, Cristiana; Sechi, Leonardo A.; Marchesoni, D.

doi:10.1016/j.fertnstert.2008.07.1731

Cited by 18 publications

(9 citation statements)

References 11 publications

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“…The existing literature describing the consequences of gestational PHPT is limited, and mainly consists of case reports or case series (1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28). In total, these studies reported 33 pregnancies in women with PHPT, who did not undergo surgery.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with primary hyperparathyroidism

Abood

Vestergaard

2014

European Journal of Endocrinology

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Objective: To study pregnancy and pregnancy outcomes in women with primary hyperparathyroidism (PHPT) and in controls. Design: Register-based retrospective cohort study of women aged 16-44 years with a diagnosis of PHPT with age-and gender-matched non-exposed controls in Denmark. Methods: The patients and controls were identified using the Danish National Hospital Discharge Register for the period 1977-2010. The outcomes were determined using the Birth Register, the Abortion Register and the LPR (National Hospital Discharge Register). The primary outcome was the relative risk of abortions in patients compared with controls. Results: A total of 1057 women with PHPT and 3171 controls were identified. The number of women giving birth and experiencing abortions did not differ between the two groups (live births, PZ0.21 and abortions, PZ0.12). Also birth weight, length, Apgar score, and gestation length at abortion did not differ. Within the first year after the diagnosis was made, gestation length was lower in women with PHPT than that in controls. However, this was linked to more deliveries by caesarian sections. Conclusions: A diagnosis of PHPT did not seem to increase the rate of abortions in our study. Reducing the abortion risk may therefore not be an indication for parathyroidectomy during pregnancy in patients with mild PHPT. The PHPT diagnosis does not seem to affect birth weight, length and Apgar score. The higher number of deliveries by cesarean section after the diagnosis was made may be associated with lower gestation age. The strategy for delivery should be carefully considered in pregnant women with PHPT.

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Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with primary hyperparathyroidism

Abood

Vestergaard

2014

European Journal of Endocrinology

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“…Steroids are also used in sarcoidosis and lymphoma [9]. Definitive and curative management of parathyroid adenoma are surgical excision [2]. There are no clear guidelines regarding the timing of delivery as it is a rare disease complicating pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Acute pancreatitis complicating pregnancy is rare (incidence varies -1 in 1000-1 in 10 000 births) and PHPT as the cause of pancreatitis in pregnancy is even rarer; gall stone pancreatitis (70%) and hypertriglyceridemia being the most common causes of acute pancreatitis in pregnancy [1]. Less than 200 cases of PHPT in pregnancy have been reported in the English literature, and its prevalence in the general population is reported to be around 0.15% [2]. Women are 3 times more affected than men.…”

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confidence: 99%

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Recurrent Pancreatitis Due to Parathyroid Adenoma in Pregnancy

Boorugu¹,

Surapaneni²,

Vadlamani³

et al. 2020

IJCR

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Hyperparathyroidism complicating pancreatitis is relatively rare in pregnancy, but it is associated with significant maternal and fetal morbidity. This case report describes a pregnant lady with recurrent pancreatitis. Etiologic workup for recurrent pancreatitis revealed hypercalcemia secondary to hyperparathyroidism. The management of hyperparathyroidism includes treatment of hypercalcemia and definitive management of hyperparathyroidism which is the surgical excision of the abnormal gland. However, the timing of the surgery in a pregnant woman needs to be individualized. A multidisciplinary team approach is mandatory for better outcomes.

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“…160,161 In another case, MRI successfully located a 2.2 cm parathyroid adenoma that ultrasound failed to detect. 162 Despite the usual absence of imaging studies, minimally invasive surgery has been done during pregnancy. 160,[163][164][165] One such minimally invasive procedure was guided by a needle biopsy that revealed a very high concentration of PTH.…”

Section: Management Strategiesmentioning

confidence: 99%

Parathyroid Function and Disease during Pregnancy, Lactation, and Fetal/Neonatal Development

Kovacs

2015

The Parathyroids

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Primary hyperparathyroidism in pregnancy

Cited by 18 publications

References 11 publications

Pregnancy outcomes in women with primary hyperparathyroidism

Pregnancy outcomes in women with primary hyperparathyroidism

Recurrent Pancreatitis Due to Parathyroid Adenoma in Pregnancy

Parathyroid Function and Disease during Pregnancy, Lactation, and Fetal/Neonatal Development

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