Primary Infiltrating Signet Ring Carcinoma of the Eyelids

Jakobiec, Frederick A.; Austin, Paul R.; Iwamoto, Takeo; Trokel, Stephen L.; Marquardt, Merlin D.; Harrison, Winston

doi:10.1016/s0161-6420(83)34576-0

Cited by 75 publications

(48 citation statements)

References 18 publications

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“…It has been postulated to originate from the apocrine sweat gland 3,9 or the eccrine sweat gland. cell/histiocytoid carcinoma of the eyelid is indolent, but it extends to the adjacent eyelid, involves the adjacent orbit, and often recurs over many years with metastasis to the regional lymph node 1,10,11 and internal viscera.…”

Section: Discussionmentioning

confidence: 99%

A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Iwaya

Uehara

Yoshizawa

et al. 2012

The American Journal of Dermatopathology

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Disclosure: There are no conflicts of interest to declare. AbstractPrimary signet-ring cell/histiocytoid carcinomas of the eyelid are extremely rare tumors considered to originate from sweat glands. Here, we report the case of a 72-year-old man diagnosed with primary signet-ring cell/histiocytoid carcinoma of the eyelid and present immunohistochemical analyses of the eyelid apocrine gland (Moll gland) and apocrine and eccrine sweat glands of perineum and axilla. Widespread infiltration of tumor cells with signet-ring cell or histiocytoid appearance was observed in his left eyelid, orbit, and periocular lesion.

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Section: Discussionmentioning

confidence: 99%

A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Iwaya

Uehara

Yoshizawa

et al. 2012

The American Journal of Dermatopathology

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“…Thereafter, similar cases of PCSRCC have been reported, exclusively involving the eyelids. [17][18][19] Recently, a few cases involving the axilla have been reported. 20,21 None of the reported cases had any detectable primary internal malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 None of the reported cases had any detectable primary internal malignancies. Previous investigators have agreed that PCSRCC is of eccrine origin, 14,16,18 while recent investigators have insisted on an apocrine origin. 18,20 Either way, PCSRCC is a primary cutaneous, poorly differentiated, mucin-producing adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

Kiyohara

Kumakiri

Kouraba

et al. 2006

Journal of the American Academy of Dermatology

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Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocarcinomas. It is defined as a diffuse malignant epithelial neoplasia localized in the dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of visceral adenocarcinoma. We present 2 cases of PCSRCC, which involved eyelids and axilla respectively. Despite thorough systemic workup, primary sources could not be demonstrated in either case. The tumor cells are positive for gross cystic disease fluid protein 15 in addition to a variety of glandular markers. Furthermore, both cases were immunostained with cytokeratin 20 (CK20). In conclusion, we report 2 cases of PCSRCC expressing CK20 immunoreactivity. CK20-positive primary cutaneous tumors should include PCSRCC in addition to Merkel cell carcinoma.

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“…More recent reports have favored apocrine differentiation because the tumor has Periodic Acid-Schiff-positive diastase-resistant secretions and positive immunostaining for the apocrine marker GCDFP-15 [1]. In addition, Jakobiec et al [52] observed abundant smooth and rough endoplasmic reticulum, granular cytoplasmic inclusions, cytoplasmic lumina, and lipid droplets at the ultrastructural level, which is suggestive of an apocrine origin. However, the neoplasm lacks morphological apocrine secretion, and GCDFP-15 immunoreactivity has been reported in normal eccrine glands [38,53,54].…”

Section: Discussionmentioning

confidence: 99%

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

et al. 2018

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Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.

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Primary Infiltrating Signet Ring Carcinoma of the Eyelids

Cited by 75 publications

References 18 publications

A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

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