Primary intestinal choriocarcinoma in a patient with long-standing Crohn�s disease

Pezzuto, Federica

doi:10.11138/gchir/2017.38.3.147

Cited by 4 publications

(6 citation statements)

References 4 publications

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“…Furthermore, this is an extremely rare and highly malignant tumor from which most patients die within a year of diagnosis. 6 Several hypotheses have previously been proposed to explain the pathogenesis of PGC: an origin in an abdominally displaced gonadal anlage postulated by Davidson in 1905; the peculiar degenerative change of a gastric carcinoma by Risel in 1907; 7 dislocation of totipotential germ cells during the blastula or morula stage; and de-differentiation in hCG-producing cells of the normal gastric mucosa without a preceding adenocarcinoma. 7 Among these, the most widely accepted theory is retro-differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Chen

Zou

et al. 2020

J Int Med Res

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The present study reports a rare case of a 65-year-old male patient with an exophytic ulcerative lesion in the gastric antrum. After performing a radical subtotal gastrectomy with D2 lymph node dissection and Billroth I gastrojejunostomy, histological analysis revealed a poorly differentiated adenocarcinoma combined with a biphasic pattern consisting of cytotrophoblasts and syncytiotrophoblasts. Immunohistochemical analysis showed a positive reaction with an anti-b-human chorionic gonadotropin antibody, and an abnormal increase in reproductive hormones. Furthermore, the patient succumbed to upper gastrointestinal hemorrhage in less than 3 months after the initial diagnosis, although the rupture of his liver metastasis was successfully treated by transhepatic artery embolization during the second admission.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, this is an extremely rare and highly malignant tumor from which most patients die within a year of diagnosis. 6…”

Section: Discussionmentioning

confidence: 99%

Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Chen

Zou

et al. 2020

J Int Med Res

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“…However, Ragam et al [ 13 ], used chemotherapy with bleomycin, etoposide and cisplatin and Bircher utilized methotrexate and folinic acid while the patients was still pregnant and continued with high‐risk protocol with etoposide, methotrexate and dactinomycin alternating with cyclophosphamide and vincristine, (known as EMA/CO, this is a regimen widely used in metastatic choriocarcinoma) after child birth. Pezzuto et al [ 14 ], did colectomy with lymph-nodes dissection. Although initial treatment was accompanied with β-hCG level reduction patients passed away in less than 2 years of initial treatment in Ragam et al [ 13 ] and Pezzuto et al [ 14 ] subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Pezzuto et al [ 14 ], did colectomy with lymph-nodes dissection. Although initial treatment was accompanied with β-hCG level reduction patients passed away in less than 2 years of initial treatment in Ragam et al [ 13 ] and Pezzuto et al [ 14 ] subjects. However, Bircher et al [ 15 ] case was alive and could gave birth to another child 7 years later of termination of treatments.…”

Section: Discussionmentioning

confidence: 99%

“…EMA/CO: etoposide, methotrexate and dactinomycin alternating with cyclophosphamide and vincristine. First author of the study age gender presentation IBD type Tumor location Metastatic sites IHC study positive for Treatment Ragam et al [ 13 ] 46 male fever and bloody diarrhea UC Rectosigmod Liver and Kidney βhCG, CK 7, p63, CD10, and CD30 Chemotherapy with bleomycin, etoposide and cisplatin Pezzuto et al [ 14 ] 47 male abdominal pain and melena Crohn’s disease Cecum Lung and Brain β-hCG CK-pool, CK-19 and Vimentin Total colectomy with lymph-nodes dissection Bircher et al [ 15 ] 25 Female Abdominal pain and vaginal bleeding Crohn’s disease Not found Lung Not performed Chemothera py started with methotrexate and folinic acid and continued with EMA/CO …”

Section: Discussionmentioning

confidence: 99%

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Primary rectal choriocarcinoma associated with rectal adenocarcinoma in a woman with a history of ulcerative colitis: Case report

Tafti

Sharifi

Keshvari

et al. 2020

International Journal of Surgery Case Reports

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Highlights Gestational Throphoblastic Neoplasms (GTN) includes a spectrum of pregnancy-related disorders of either benign or malignant. Gestational choriocarcinoma in a patient with a previous history of IBD could have occurred in three different scenarios. Dedifferentiation is the most accepted mechanism introduced to explain development of primary choriocarcinoma of colorectal origin. Surgical resection with lymph node dissection is the standard of treatment. Colorectal choriocarcinoma is considered pathologically similar to choriocacinoma of GTN, thus chemotherapeutic regimens are the same.

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Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Payne

Palma

Walker

et al. 2020

Head and Neck Pathol

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Extragonadal non-gestational choriocarcinoma is a rare but well-described phenomenon occurring in patients with midline germ cell tumors. Choriocarcinoma (ChC) is an aggressive neoplasm usually developing in women as a rare complication of pregnancy. In male patients ChC occurs in the testes, usually as a component of mixed germ cell tumors. Very few patients develop extragonadal choriocarcinoma with the tumor occurring in midline locations, such as the mediastinum, retroperitoneum, and central nervous system (mostly pineal gland). Non-midline choriocarcinoma can occur in the lung, gastrointestinal tract, and breast, sometimes blended with another primary malignancy. A midline choriocarcinoma manifesting as a head and neck malignancy is exceptional. During an evaluation of multiple enlarged cervical lymph nodes suspected to be lymphoma in a 72-year-old man, a core biopsy was taken from one of the left neck lymph nodes which histologically showed a necrotic malignancy with strong diffuse pancytokeratin staining. After an initial interpretation of metastatic carcinoma, further samples were taken from both tonsils and from a right level 5 neck lymph node. Histologically, all samples contained the same tumor, showing profound pleomorphism and multinucleated syncytial-type giant cells. A panel of immunohistochemistry studies were performed, including β-human chorionic gonadotropin, with positive findings leading to a diagnosis of extragonadal non-gestational choriocarcinoma.

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Primary intestinal choriocarcinoma in a patient with long-standing Crohn�s disease

Cited by 4 publications

References 4 publications

Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

Primary rectal choriocarcinoma associated with rectal adenocarcinoma in a woman with a history of ulcerative colitis: Case report

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

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