Primary Intraorbital Meningiomas

Karp, Louis A.; Zimmerman, Lorenz E.; Borit, Adam; Spencer, William H.

doi:10.1001/archopht.1974.03900060028007

Cited by 132 publications

(65 citation statements)

References 10 publications

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“…Intraorbital meningiomas commonly in volve young and middle-aged women, and interestingly the right side is more frequent ly affected [Karp et al, 1974], The present case fits well with these points.…”

Section: Discussionsupporting

confidence: 89%

“…These shunt vessels were no longer noticed during the next half century until Friesen et al [1973] revived the subject of optociliary shunt vessels and stressed the triad of signs indicating sphcno-orbital me ningioma: optociliary veins, optic disc atro phy, and long-standing blindness. Hence, several reports on this shunt vessel have ap peared in the literature [Karp et al, 1974;Rodrigues et al, 1976;Henkind and Ben jamin, 1976;Hollenhorst etal., 1978;Wright, 1977;Zakka et al, 1979].…”

Section: Discussionmentioning

confidence: 98%

“…Symptomatologically, a triad of optociliary veins, op tic atrophy and long-standing blindness has been documented in the literature for optic nerve sheath meningioma [Friesen et al. 1973;Karp et al, 1974;Rodrigues et al, 1976;Wright, 1977;Hollenhorst et al, 1978;Zakka et al, 1979]. Especially the presence of optociliary veins is strong supportive evi dence for the diagnosis of optic nerve me ningioma.…”

Section: Introductionmentioning

confidence: 99%

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Optociliary Veins Associated with Meningioma of the Optic Nerve Sheath

Tsukahara¹,

Kobayashi²,

Nakagawa³

et al. 1980

Ophthalmologica

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We report the clinical symptoms and the course of a case that showed the typical findings of a meningioma of the optic nerve sheath, characterized by visual disturbances, progressive visual field defect, proptosis, secondary atrophy of the optic disc, and shunt vessels between retinal and choroidal circulation. The shunt vessel which was demonstrated in this case by fluorescein angiography is identical with the optociliary vein reported in the literature. Fluorograms also revealed peculiar vessels at the margin of the optic disc, which have not been described in association with this tumor. CT scanning and roentgenograms of the optic canal proved useful as diagnostic tools for this tumor. The tumor was removed through a frontotemporal craniotomy, preserving the optic nerve. The histopathological diagnosis was meningothelial meningioma.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Optociliary Veins Associated with Meningioma of the Optic Nerve Sheath

Tsukahara¹,

Kobayashi²,

Nakagawa³

et al. 1980

Ophthalmologica

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“…The classification of these lesions is based on the presence (primary lesion) or absence (secondary lesion) of a connection with the central nervous system. The following ectopic locations of meningiomas have been reported: skull, [1][2][3] scalp, [4] orbit, [5] paranasal sinuses, [6] nasopharynx, [6,7] neck [8,9] and skin; [10,11] occasionally in the lung, [12] mediastinum, [13] adrenal gland, [9] paraspinal region, [14] and even in a finger. [10] These primary extradural meningiomas (PEM) are rare tumours accounting for less than 2% of all meningiomas.…”

Section: Discussionmentioning

confidence: 99%

Giant intraosseous meningioma mimicking fibrous dysplasia

Huscher¹,

Öhlschlegel²,

Fournier

2016

CRCP

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We illustrate a case of a giant primary intraosseous meningiomas (PIMs) with optic nerve compression treated by partial resection. A 48-year-old female presented with visual disturbances exophthalmus, diplopia and eye pain due to optic nerve compression. The patient had a past history of fibrous dysplasia treated surgically with partial resection by ENT in 2010. Histology confirmed the diagnosis. Two years later she presented with further decrease in visual acuity and diffuse hyperostosis. In this context she underwent a neurosurgical procedure consisting in craniotomy and further partial resection of the lesion including optic canal decompression. The second pathological examination demonstrated an extensive meningioma (WHO grade I) of the skull base.We recommend that in cases of diffuse hyperostosis the differential diagnosis include diffuse intraosseous meningioma. If complete surgical resection is not achievable, a biopsy to confirm the diagnosis is recommended. Treatment options include complete or partial resection followed by adjuvant radiotherapy.Key Words: Skull base, Meningioma, Hyperostosis, Fibrous dysplasia CASE REPORTA 48-year-old woman presented with a 3-year history of progressive right sided visual disturbance, exophthalmus, diplopia and eye pain. The patient underwent a cranial CT scan which showed a diffuse bilateral frontal and skull base hyperostosis, especially evident on the right side, and extending bilaterally from the sphenoid bones, down to the clinoid processes, orbits, temporal bones and the right frontal bone as seen in Figure 1. The right optic nerve was displaced with narrowing of the optic canal. These findings were consistent with fibrous dysplasia. Diffuse hyperostosis could also be consistent with an osteosarcoma, although this was less likely. The mass effect of the tumor involving both orbits caused compression of the eye muscles with subsequent exophthalmos, also more evident on the right side. The general practitioner referred the patient to an ophthalmologist who diagnosed exophthalmos with compressive optic nerve atrophy, decreased vision and secondary glaucoma. The ophthalmologist then referred the patient to an ENT doctor.The patient underwent surgical decompression of the right orbit via a transethmoidal, transsphenoidal and transpalpebral approach. During the operation, visualization of the orbital content was inadequate and bleeding from the bone prevented completion of the planned operation. The ENT suggested a second operation via a right subfrontal craniotomy to further decompress the orbit and the optic nerve. The first histopathological analysis seemed to confirm the suspicion of fibrous dysplasia and the patient was discharged. Ophthalmological and radiological follow-up was conducted via CT and MRI.

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“…7,10,15 On funduscopic examination, a pathologic appearance of the optic disc is revealed in virtually every case. 2,3,13,[15][16][17][18] This may consist of disc swelling, various degrees of optic atrophy, or both. Intracanalicular ONSM tends to initially present with an atrophic disc.…”

Section: Pretreatment Aspectsmentioning

confidence: 99%

Primary optic nerve sheath meningioma

Jeremić

Pitz

2007

Cancer

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Biotechnological production of weak organic acids such as succinic acid is most economically advantageous when carried out at low pH. Among naturally occurring microorganisms, several bacterial strains are known to produce considerable amounts of succinic acid under anaerobic conditions but they are inefficient in performing the low‐pH fermentation due to their physiological properties. We have proposed therefore a new strategy for construction of an aerobic eukaryotic producer on the basis of the yeast Yarrowia lipolytica with a deletion in the gene coding one of succinate dehydrogenase subunits. Firstly, an original in vitro mutagenesis‐based approach was proposed to construct strains with Ts mutations in the Y. lipolytica SDH1 gene. These mutants were used to optimize the composition of the media for selection of transformants with the deletion in the Y. lipolytica SDH2 gene. Surprisingly, the defects of each succinate dehydrogenase subunit prevented the growth on glucose but the mutant strains grew on glycerol and produced succinate in the presence of the buffering agent CaCO3. Subsequent selection of the strain with deleted SDH2 gene for increased viability allowed us to obtain a strain capable of accumulating succinate at the level of more than 45 g L−1 in shaking flasks with buffering and more than 17 g L−1 without buffering. The possible effect of the mutations on the utilization of different substrates and perspectives of constructing an industrial producer is discussed. Biotechnol. Bioeng. 2010;107:673–682. © 2010 Wiley Periodicals, Inc.

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Primary Intraorbital Meningiomas

Cited by 132 publications

References 10 publications

Optociliary Veins Associated with Meningioma of the Optic Nerve Sheath

Optociliary Veins Associated with Meningioma of the Optic Nerve Sheath

Giant intraosseous meningioma mimicking fibrous dysplasia

Primary optic nerve sheath meningioma

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