Primary intraosseous squamous cell carcinoma arising from ameloblastoma of the mandible: A case report

Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report

“…The carcinoma component in the current case had higher Ki-67 proliferation index and p53 expression as compared to the DA areas of the lesion. To our knowledge there is no convincing evidence in published literature of a squamous cell carcinoma arising from a conventional ameloblastoma in contrast to commonly recognized cases of squamous cell carcinoma developing in a preexisting odontogenic cysts [1,14,15].…”

“…In the current case the patient had no prior history of squamous cell carcinoma at any other site or any other time and thus metastatic origin can be ruled out. Three cases of primary intra osseous carcinoma (PIOC) have been reported in literature [9,15,16], they affected both the mandible and maxilla and were thought to be arising from ameloblastoma. However the authors did not identify or describe the characteristic morphologic features of ameloblastoma in these lesions.…”

Keratoameloblastomatous transformation of a recurrent unicystic ameloblastoma: a novel case raising diagnostic and classification difficulties

“…There has been only a single reported case of recurrent UAM, expressing an unusual histological transformation. 11 The original UAM lesion recurred 23 years later in the form of granular/acanthomatous AM of the follicular type with invasive foci of squamous cell carcinoma, but with an absolute lack of KAM/SOKC features. There are two possible explanations for the natural history of the present lesion.…”

Editorial- Os tumores odontogênicos ocorrem mesmo na clínica odontológica?

“…O ameloblastoma é uma neoplasia benigna, relativamente comum (10 a 49% dos tumores odontogênicos) 1,2,3 , decorrente do epitélio odontogênico, que pode envolver tecidos moles (ameloblastoma periférico) 4 ou tecido ósseo da maxila e mandíbula, com maior incidência na mandíbula, com variáveis formas e classificações histopatológicas, observado em pessoas jovens, segunda e terceira décadas de vida ou mais tardiamente 1,2,3 Quanto aos aspectos radiográficos e imaginológicos podem ser uniloculares ou multiloculares, se assemelhando a lesão cística 5,6 ou então sob a forma de múltiplas áreas radiolúcidas 2 .…”

“…Dos danos produzidos a cirurgias extensas e necessidade de reconstruções, nota-se que também há casos de sua correlação com carcinomas de células escamosas em mandíbula 6 , o comportamento dos ameloblastomas é considerado como mais ou menos agressivo 7 .…”