Primary intratesticular leiomyosarcoma

Yoshimine, Shunsuke; Kono, Hidaka; Nakagawa, Ken; Kikuchi, Eiji; Miyajima, Akira; Kameyama, Kaori; Mukai, Makio; Oya, Mototsugu

doi:10.5489/cuaj.1184

Cited by 11 publications

(15 citation statements)

References 9 publications

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“…It is said that excluding these cases is important to diagnose primary testicular sarcoma because primary testicular sarcoma has better prognosis than testicular GCTs with SC [13]. In only six cases of 41 cases (15%) including our case, they had metastasis and/or recurrence in a term of observation after treatment (9 weeks to 21 years) [22,28,30,39]. However, two cases of these six cases were considered that tumors arose from tunica and epididymis and they might be cases that should be distinguished from primary testicular tumors [30].…”

Section: Discussionmentioning

confidence: 94%

“…To our knowledge, 40 cases had been reported, including 15 lieomyosarcomas [11][12][13][14][15][16][17][18][19][20][21][22][23][24], seven rhabdomyosarcomas [25][26][27][28][29][30], five spindle sarcomas [31][32][33][34], four osteosarcomas [35][36][37][38], two fibrosarcomas [36,39], two pleomorphicsarcomas [33], two liposarcomas [33,40], one chondrosarcoma [3], one kaposi sarcoma [41] and one undifferentiated sarcoma [13].…”

Section: Discussionmentioning

confidence: 99%

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Cytogenetic Findings of an Undifferentiated Testicular Sarcoma

et al. 2016

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Primary testicular sarcomas are extremely rare. In contrast, germ cell tumors (GCTs) with sarcomatous components (SCs) that can have similar pathologic features are more frequently reported. We report a primary undifferentiated testicular sarcoma with cytogenetic analysis for amplification of 12p. A 36-year-old male initially presented with 9.4 cm right testicular tumor and no metastatic disease. He was lost to follow-up but re-presented 2 years later with tumor growth to 21 cm and multiple pulmonary and bone metastases. Histologically, the testicular tumor revealed an undifferentiated sarcoma. Fluorescence in situ hybridization (FISH) of paraffin-embedded tissue showed no amplification of 12p. Gain of isochromosome 12p (i(12p)) is a specific chromosomal anomaly present in most GCTs. The cytogenetic analysis indicated the possibility that the tumor was not of GCT origin. This is the first report of primary testicular undifferentiated sarcoma with cytogenetic analysis for i(12p).

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Cytogenetic Findings of an Undifferentiated Testicular Sarcoma

et al. 2016

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“…All four have been stated as having high mitotic rate although in only 2 cases numeric counts have been indicated (2/10 hpf (14) and 8/10 hpf (18)). Two out of four were notably bulky, 20 cm (14) and 23 cm (5) in the largest diameter. Yet, many of the non-metastasizing indolent intratesticular leiomyosarcomas have also been reported as high-grade lesions with numerous mitotic fi gures (e.g.…”

Section: Türk Patoloji Dergisi/turkish Journal Of Pathology Ertoy Baymentioning

confidence: 99%

“…Nevertheless, the biological behavior of these tumors is not easy to predict and four patients developed metastatic disease (5,12,14,18). High tumor grade is the common feature among the metastasizing sarcomas.…”

Section: Türk Patoloji Dergisi/turkish Journal Of Pathology Ertoy Baymentioning

confidence: 99%

“…Approximately one hundred paratesticular leiomyosarcomas have been reported in the literature (1). Primary intratesticular leiomyosarcoma is even more rare with only 18 cases known so far (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Herein, we would like to document an additional case of primary intratesticular leiomyosarcoma with its clinical and pathological features.…”

Section: Introductionmentioning

confidence: 99%

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Primary low grade intratesticular leiomyosarcoma: case report and review of the literature

Abdullazade¹,

Kara²,

Akdoğan³

et al. 2013

TJPATH

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A 49-year-old male presented with a painful mass in the left scrotum. An inguinal orchiectomy was performed. Pathological examination revealed a well-diff erentiated leiomyosarcoma completely located inside the testicular parenchyma. We report this unusual case because primary leiomyosarcoma of the testis proper is extremely rare; our patient being the 19th case recorded thus far in the medical literature. It can lead to significant clinical and diagnostic diff iculty due to its wide diff erential diagnosis and extreme rarity.

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Testicular leiomyosarcoma: A case report and literature review

Hussein¹,

Dergamoun²,

Hachem³

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Leiomyosarcoma is a malignant mesenchymal tumor derived from the smooth muscle, it represents approximately 7% of all soft tissue sarcomas. Male genitourinary leiomyosarcomas are rare (Abdullazade et al., 2013 [ 1 ]). Primary testicular leiomyosarcoma is an exceptional entity with only 30 cases reported in the literature (Giridhar et al., 2011). Due to its rarity, additional studies are necessary to better define the optimal therapeutic management. Case presentation We report a case of a 42-years-old male diagnosed in the urology department A of the University Hospital Ibn Sina in Rabat who complains of testicular swelling. The anatomopathological examination and immunohistochemical study revealed a leiomyosarcoma therefore, a radical inguinal orchiectomy with a primary ligation of the spermatic cord was performed for diagnostic and therapeutic purposes. The assessment of extension did not reveal any lymph node location or secondary appearance thus the decision of the multidisciplinary meeting opted for regular cancer check-ups without adjuvant treatment. Discussion The actual etiology of testicular leiomyosarcoma is still unknown added to its clinical presentation and radiological results that are non-specific. Conclusion Leiomyosarcoma of the testis is a very rare tumor and its clinical and radiological presentation remains similar to other testicular malignancies.

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Primary intratesticular leiomyosarcoma

Cited by 11 publications

References 9 publications

Cytogenetic Findings of an Undifferentiated Testicular Sarcoma

Cytogenetic Findings of an Undifferentiated Testicular Sarcoma

Primary low grade intratesticular leiomyosarcoma: case report and review of the literature

Testicular leiomyosarcoma: A case report and literature review

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