Primary Liver Tumours – Presentation, Diagnosis and Surgical Treatment

Bektaş, H.; Schrem, Harald; Kleine, Moritz; Tamac, Azad; Vondran, Florian W. R.; Uzunyayla, S.; Klempnauer, J.

doi:10.5772/55932

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…Intrahepatic cholangiocarcinoma (ICC) is relatively rare and accounts for only 5–30% of all primary liver cancers . ICC is, however, the second most common primary liver malignancy after hepatocellular carcinoma (HCC).…”

Section: Introductionmentioning

confidence: 99%

Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: A population-based analysis

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: A population-based analysis

et al. 2014

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“…1,2 The incidence of ICC has increased worldwide, from 3.2 per 1,000,000 in 1975 to 8.5 per 1,000,000 in 2000, and has continued to increase during the last decade. 3–5 The prognosis of patients with ICC is poor, with an estimated median survival time of 18–39 months and a median 5-year survival rate of 25–40 %.…”

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confidence: 99%

Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

et al. 2014

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Background The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P < 0.001). At the final pathology exam, the patients in group B were more likely to show evidence of vascular invasion (22.5 vs. 38.5 %), direct invasion of contiguous organs (6.5 vs. 12.9 %), and nodal metastasis (13.3 vs. 21.0 %) (all P < 0.05). Interestingly, the incidences of postoperative complications (39.3 vs. 46.8 %) and hospital mortality (1.1 vs. 3.7 %) were similar between the two groups (both P > 0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P < 0.05) and disease-free survival (DFS) (22.6 vs. 8.2 %; P < 0.05) than the group B patients. For the patients in group B, the factors associated with a worse OS included more than three tumor nodules [hazard ratio (HR), 1.56], nodal metastasis (HR, 1.47), and poor differentiation (HR, 1.48). Conclusions Liver resection can be performed safely for patients with large or multifocal ICC. The long-term outcome for these patients can be stratified on the basis of a prognostic score that includes tumor number, nodal metastasis, and poor differentiation.

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“…Although intrahepatic cholangiocarcinoma (ICC) is a relatively rare tumor, accounting for 10-15% of all primary liver cancer [1,2], the incidence of this disease has steadily increased in both Japan and throughout the world [3][4][5]. The prognosis of ICC is dismal, with an estimated median survival of only 18-19 months and an estimated 5-year survival rate between 25-40% [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Role of Prophylactic Lymph Node Dissection in Patients with Intrahepatic Cholangiocarcinoma

2016

J Surg

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Purpose:We investigated the role of prophylactic lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC).Methods: A retrospective analysis was performed evaluating the impact on survival of prophylactic LND and preoperative risk factors for histological lymph node metastasis (LNM) in a cohort of 49 patients with ICC of the mass-forming type, who underwent curative resection between 1995 and 2013.Results: There were no differences in both disease-free survival (DFS) and overall survival (OS) between the patients without LND and the patients with LND who did not have LNM. Multivariate analysis revealed that serum CA19-9 level > 150 U/mL and LN size > 5 mm on preoperative computed tomography (CT) were the significant preoperative risk factors for LNM. None of the patients with LN size < 5 mm on preoperative CT and serum CA19-9 level ≤ 150 U/mL had LNM.Conclusions: Prophylactic LND did not significantly improve DFS or OS in the present study. Regional LND could be omitted for patients with LN size < 5 mm in preoperative CT and serum CA19-9 level ≤ 150 U/ mL who are unlikely to have LNM.

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Primary Liver Tumours – Presentation, Diagnosis and Surgical Treatment

Cited by 4 publications

References 46 publications

Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: A population-based analysis

Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: A population-based analysis

Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

The Role of Prophylactic Lymph Node Dissection in Patients with Intrahepatic Cholangiocarcinoma

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