Primary Malignant Peripheral Nerve Sheath Tumor of the Breast—A Case Report

Chalkoo, Mushtaq; Ahangar, Shahnawaz; Laharwal, Asim Rafiq; Patloo, Aasim Mushtaq; Mohd, Abbass; Dar, Shabir Ahmed

doi:10.4236/ss.2011.23028

Cited by 8 publications

(11 citation statements)

References 11 publications

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“…(2010) [ 20 ] Nigerian 41 F NF1 10 cm No Modified radical mastectomy with axillary dissection 7 Yes (after 9 months) No Chalkoo et al . (2011) [ 10 ] Indian 60 F Sporadic 26 cm No Simple mastectomy with axillary clearance 1 2 No No Manimozhi et al . (2015) [ 18 ] Indian 40 F No info No info No No info No info No info No info Abbreviations : F female, info information, LN lymph node, M male, NF1 neurofibromatosis1, RT radiation therapy …”

Section: Discussionmentioning

confidence: 99%

“…Adverse prognostic factors include tumor larger than 5 cm, presence of von Recklinghausen’s disease, tumor grade, extent of resection, truncal location, and heterologous rhabdomyoblastic differentiation [ 23 , 25 ]. However, no report is available on median survival or prognosis of MPNST of the breast in the literature [ 10 ]. Our patient has not experienced local and metastatic recurrence since completion of all adjuvant treatment after surgery; from the time of first surgery to date she has been surviving well for more than 3 years.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, MPNST has similarities with other primary breast sarcomas which can make diagnosis difficult [ 9 , 10 ]. MPNST of the breast is often unsuspected and may be misdiagnosed without high clinical suspicion and immunohistochemistry (IHC) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Unusual primary breast cancer – malignant peripheral nerve sheath tumor: a case report and review of the literature

Shuayb

Begum

2017

J Med Case Reports

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BackgroundSarcomas are a rare type of breast malignancies and malignant peripheral nerve sheath tumors of the breast are even rarer. There are no specific clinical and radiological features for the diagnosis of this tumor and histological features are also reported to be nonspecific. Therefore, immunohistochemistry is required for its diagnosis. A definitive treatment protocol is unavailable because of its rarity.Case presentationWe report a case of a sporadic form of breast malignant peripheral nerve sheath tumor found in a 16-year-old Asian Bangladeshi girl. She experienced local recurrence and she had multiple left breast lumps four times in a very short period after repeated surgeries. However, she was later managed successfully with chemotherapy and locoregional radiotherapy. A chemotherapy protocol with ifosfamide, vincristine, and actinomycin was used and radiotherapy was given with a total dose of 50 Gy given in 25 fractions of 2 Gy by a 6 MV photon linear accelerator followed by 10 Gy boost given in 5 fractions of 2 Gy by 9 MeV electron energy. With more than 3 years of periodic follow-up, she is still well without any locoregional and metastatic recurrence.ConclusionsThis report suggests proper immunohistochemical analysis whenever a breast sarcoma is found in order to find a rare histological variety. We believe that malignant peripheral nerve sheath tumor of the breast can be managed by total mastectomy followed by adjuvant chemotherapy and radiotherapy. Long-term meticulous follow-up is required to develop an optimum therapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unusual primary breast cancer – malignant peripheral nerve sheath tumor: a case report and review of the literature

Shuayb

Begum

2017

J Med Case Reports

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“…Chalkoo, et al [15] 60 F Breast -Nil Nil 1 year Miguchi, et al [16] 71 M Greater omentum -Nil Nil 1 year Elli, et al [17] 13 M Posterior mediastinum + Lung RT+CT Death Godfrey, et al [18] 49 M Elbow + Axillary lymph node Nil 5 years Miyakoshi, et al [19] 75 M Posterior mediastinum -Lung RT 6 months Sari, et al [20] 53 M Urinary bladder -Nil Nil 2 years Özel, et al [21] 63 F Vulva -Nil NA NA Park, et al [22] 31 F Adrenal gland -CT Yone, et al [23] 4 M Cauda equina -Brain and spine…”

Section: Discussionmentioning

confidence: 99%

Brain abscess: Current management

Panigrahi

Mishra

Das

et al. 2013

Journal of Neurosciences in Rural Practice

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Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma. Most arise in association with major nerve trunks. Their most common anatomical sites are the proximal portions of the upper and lower extremities and the trunk. MPNSTs have rarely been reported in literature to occur in other unusual body parts. We review all such cases reported till now in terms of site of origin, surgical treatment, adjuvant therapy and outcome and shortly describe our experience with two of these cases. Both of our case presented with lump at unusual sites resembling neurofibroma, one at orbitotemporal area and other in the paraspinal region with characteristic feature of neurofibroma with the exception that both had very short history of progression. They underwent gross total removal of the tumor with adjuvant radiotherapy postoperatively. At 6-month follow-up both are doing well with no evidence of recurrence.

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“…The most common anatomic sites include proximal portion of the upper and lower extremities and trunk (5). MPNST in the breast is extremely rare and our extensive literature search (PubMed, Scopus, Web of Science, and Google Scholar) revealed only nine reported cases in the English literature (summarized in Table 1, references [6][7][8][9][10][11][12][13][14]. Two of the previously reported cases were associated with NF-1 whose signs were not present in our patient.…”

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confidence: 93%