Primary Mesenchymal Chondrosarcoma in the Pericardium of a Dog

R, Larock; Ginn, Pamela E.; Burrows, Colin F.; Newell, Sue; Henson, Kristin L.

doi:10.1177/104063879700900412

Cited by 22 publications

(27 citation statements)

References 11 publications

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“…Our histological, immunohistochemical and ultrastructural findings are similar to those reported previously for extraskeletal myxoid chondrosarcoma in man and other animals [8,17,18]. In dogs, extraskeletal chondrosarcoma occurs in the lung [19], omentum [19], heart including pericardium [1,9,13,19,22], spleen [15], abdomen [20], retroperitoneum [16], and liver [3]. Most previously reported cases involved variants of extraskeletal mesenchymal chondrosarcoma and occurred in adult or old dogs aged 18 months to 17 years (mean 7.8 years).…”

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confidence: 77%

“…Almost all the tumors in this series affected adults (mean age 49 years), and the only child was a 13-year-old girl. In animals, reports of extraskeletal chondrosarcoma are rare, and most cases have been described as a single mass in adult or old dogs [1,9,13,19,22]. In this case report, we describe an extraskeletal myxoid chondrosarcoma with systemic metastasis in a five-month-old dog.…”

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confidence: 87%

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Extraskeletal Myxoid Chondrosarcoma with Systemic Metastasis in a Five-Month-Old Irish Setter Dog

Kojima

Hatai

Oyamada

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Extraskeletal myxoid chondrosarcoma was found in a five-month-old male Irish setter dog. At necropsy, the largest mass, measuring 15 × 13 × 13 cm, was found in the right caudal lobe of the lung, and metastatic small masses were observed in multiple organs. Microscopically, the tumor comprised mainly atypical mesenchymal cells and myxoid stroma, which stained positively with Alcian blue. Immunohistochemically, the tumor cells stained positively for vimentin, S-100 protein, neuron-specific enolase, calretinin, and chromogranin A. Ultrastructurally, the cytoplasm of the tumor cells was comprised abundant rough endoplasmic reticulum, mitochondria, Golgi complex, free ribosomes and short irregular microvillous processes extending from the cytoplasm. Based on these pathological findings, this tumor was diagnosed as extraskeletal myxoid chondrosarcoma. Primary chondrosarcomas arise from existing normal cartilage and perichondrium at sites such as the pelvis, nasal cavity, sternum, and ribs, and less often in long bones. Extraskeletal chondrosarcoma was first described as an entity in 1953 by Stout and Verner [23]. Characteristically, in most reported cases, extraskeletal chondrosarcoma exhibits less aggressive behaviour than its skeletal counterpart [5,21,24].A series of extraskeletal myxoid chondrosarcoma in man was described in 1972 by Enzinger and Shiraki [5]. Almost all the tumors in this series affected adults (mean age 49 years), and the only child was a 13-year-old girl. In animals, reports of extraskeletal chondrosarcoma are rare, and most cases have been described as a single mass in adult or old dogs [1,9,13,19,22]. In this case report, we describe an extraskeletal myxoid chondrosarcoma with systemic metastasis in a five-month-old dog.A five-month-old male Irish setter dog was referred to our veterinary hospital with a history of anorexia, dyspnea, diarrhea, and exophthalmos of the left eye. The dog had been fully vaccinated, and there was no previous medical or surgical history. Under sedation, radiographs of the thoracic cavity were taken and confirmed the presence of a large, poorly defined mass lying within the right caudal lobe of lung. Approximately three-fourths of the thoracic cavity was occupied by the pulmonary mass, and systemic metastasis was confirmed by abdominal radiographs. Because of the poor prognosis, the dog was euthanized. A necropsy examination was performed.Tissue samples from all major organs and masses were fixed in 10% buffered formalin, embedded in paraffin wax, and sectioned. All sections were stained with hematoxylin and eosin (HE), and selected sections were prepared for staining for Alcian blue (pH 2.5), periodic acid-Schiff (PAS), and immunohistochemistry. The following primary antibodies were used: S-100 protein (Nichirei Biosciences, Tokyo, Japan), neuron-specific enolase (NSE, Nichirei), vimentin (Nichirei), cytokeratin (CK) AE1/AE3 (Nichirei), α-smooth muscle actin (SMA, Dako-Japan, Kyoto, Japan), desmin (Dako-Japan), calretinin (Zymed Laboratories, Carlsbad, CA, ...

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supporting

confidence: 77%

mentioning

confidence: 87%

Extraskeletal Myxoid Chondrosarcoma with Systemic Metastasis in a Five-Month-Old Irish Setter Dog

Kojima

Hatai

Oyamada

et al. 2012

The Journal of Veterinary Medical Science

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“…O quimiodectoma é o tumor de maior ocorrência, depois do hemangiossarcoma cardíaco (Walter & Rudolph 1996, Ware & Hopper 1999. Também são descritos como tumores primários do coração em caninos o rabdomiossarcoma (Aupperle et al 2007), o rabdomioma (Girard et al 1999, Radi & Metz 2009, o ϐibrossarcoma (Madarame et al 2004, Speltz et al 2007, o neuroϐibrossarcoma (Aupperle et al 2007), os mesenquimomas malignos (tumores constituídos por vá-rios tipos de células mesenquimais) (Machida et al 2002), o schwannoma maligno (Wohlsein et al 2005), o condrossarcoma (Albers et al 1997, LaRock et al 1997, o osteossarcoma (Schelling & Moses 1994, Warman et al 2006, o mixoma (Symbas et al 1976), o mixoma valvular (Machida et al 2003, Akkoc et al 2007, o leiomiossarcoma (Fews et al 2008), o mesotelioma (Cobb & Brownlie 1992, Girard et al 1999, Brower et al 2006, o lipoma (Brambilla et al 2006, Ben-Amotz et al 2007) e o sarcoma mioϐibroblástico (Grieco et al 2008).…”

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Prevalência e aspectos anatomopatológicos das neoplasias primárias do coração, de tecidos da base do coração e metastáticas, em cães do Sul de Minas Gerais (1994-2009)

et al. 2012

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Este estudo teve como objetivo determinar a prevalência e achados anatomopatológicos de tumores primários e metastáticos do coração ou de tecidos da base do coração, diagnosticados em caninos do Sul de Minas Gerais. O diagnóstico foi realizado mediante análise histopatológica e imuno-histoquímica das neoplasias. Durante os anos de 1994-2009, foram realizadas 2397 necropsias em caninos. Neoplasias no coração foram detectadas em 31 cães (1,29%), onde, sete (22,58%) eram primárias e 24 (77,42%) metastáticas. As neoplasias diagnosticadas como primárias do coração foram o hemangiossarcoma (1/7) e o mixoma (1/7); e como primárias da base do coração o quimiodectoma (3/7) e o carcinoma de tireoide ectópica (2/7). A frequência foi maior em cães machos (5/7), da raça Boxer (3/7) e com idade média de 9,7±1,88 anos. Nas neoplasias metastáticas, a frequência foi maior em fêmeas (15/24), em cães da raça Rottweiler (7/24) e a idade média foi de 7,5±3,23 anos, sendo o linfoma de células T a neoplasia metastática de maior ocorrência (7/27).

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“…(Casadei et al, 1991). Em medicina veterinária, o condrossarcoma extra-esquelético é um tumor raro de tecido mole (Thompson e Pool, 2002) embora já relatado em órgãos como pericárdio, baço e pele (LaRock et al, 1997;Miller et al, 2005;Romanucci et al, 2005). Contudo, na literatura consultada, somente um caso de condrossarcoma de língua foi descrito em eqüino (Wilson e Anthony, 2007) ao contrário da medicina humana em que alguns condrossarcomas de base de língua já foram descritos (Forman, 1967).…”

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