Primary Monosymptomatic Nocturnal Enuresis: Monotherapy vs Combination Therapy

Sharifiaghdas, Farzaneh; Sharifiaghdas, Sepideh; Taheri, Maryam

doi:10.1016/j.urology.2016.02.013

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…After removing duplicates, 1 625 studies were screened by reading titles and abstracts. Full-text assessment was carried out on a total 57 articles, and a final total of 18 [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] RCTs with 1 649 patients was included in the present analysis.…”

Section: Included Studies Characteristicsmentioning

confidence: 99%

Comparison of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agents in the management of paediatric monosymptomatic nocturnal enuresis: a network meta‐analysis

et al. 2018

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The network meta-analysis showed that desmopressin had similar efficacy to alarm therapy but a higher relapse rate. Desmopressin plus AA therapy was associated with better efficacy than and a similar relapse rate to desmopressin monotherapy. Desmopressin plus alarm therapy was similar to both desmopressin and alarm monotherapy in efficacy. All treatments, including desmopressin plus AAwere associated with tolerable adverse events; however, additional high-quality studies are needed for further evaluation of these treatments.

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Section: Included Studies Characteristicsmentioning

confidence: 99%

Comparison of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agents in the management of paediatric monosymptomatic nocturnal enuresis: a network meta‐analysis

et al. 2018

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“…[ 40 ] Combination therapy with desmopressin ODT and tolterodine was more efficacious in reducing the number of wet nights and preventing relapse compared to desmopressin ODT alone. [ 41 ]…”

Section: Treatment Of Primary Nocturnal Enuresismentioning

confidence: 99%

Nocturnal enuresis in india: Are we diagnosing and managing correctly?

Reddy¹,

Malve²,

Nerli³

et al. 2017

Indian J Nephrol

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Nocturnal enuresis is a common problem affecting school-aged children worldwide. Although it has significant impact on child's psychology, it is always under-recognized in India and considered as a condition which will outgrow with advancing age. Nocturnal enuresis classified as primary or secondary and monosymptomatic or nonmonosymptomatic. Factors that cause enuresis include genetic factors, bladder dysfunction, psychological factors, and inappropriate antidiuretic hormone secretion, leading to nocturnal polyuria. Diagnosis consists of detailed medical history, clinical examination, frequency-volume charts, and appropriate investigations. The frequency-volume chart or voiding diary helps in establishing diagnosis and tailoring therapy. The first step in treating nocturnal enuresis is to counsel the parents and the affected child about the condition and reassure them that it can be cured. One of the effective strategies to manage enuresis is alarm therapy, but currently, it is not easily available in India. Desmopressin has been used in the treatment of nocturnal enuresis for close to 50 years. It provides an effective and safe option for the management of nocturnal enuresis. This review covers the diagnosis and management of nocturnal enuresis and introduces the concept of “bedwetting clinics” in India, which should help clinicians in the thorough investigation of bedwetting cases.

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“…T he need for increasing the eff ectiveness of enuresis therapy remains a topical problem at the present time 1,2,3 . The prevalence of PMNE is from 1.6% 4 -5,3% 5 in adolescents, up to 7.5% 6 12,4% 7 among 5-10 year old children.…”

Section: Introductionmentioning

confidence: 99%

Combination of Alarm-intervention and Reboxetine in Therapy- Resistant Enuresis

Kosilov

Kuzina

Gainullina

et al. 2018

J. Nepal Paedtr. Soc.

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Introduction: The first-line treatments of primary monosymptomatic night enuresis (PMNE) are alarm intervention and desmopressin. Some patients are resistant to these modes of treatment. Therefore Reboxetine has been used to treat PMNE in these scenarios in recent years and published in many studies. The aim of the study was to determine effectiveness and safety of combination of Alarm intervention and Reboxetine, to treat patients with therapyresistant enuresis.Material and Methods: Two hundred and nineteen children of both sexes were participated in the experiment (average age, 11.3 years). Participants were divided into three groups: Group A (71 patients, Alarm intervention), Group B (79 patients, Reboxetine as monotherapy), Group C (69 patients, Alarm intervention + Reboxetine). The duration of treatment was twelve weeks, followed by follow-up period of twelve weeks to see efficacy.Result: There was no significant change in number of enuresis episodes per week before and after treatment in a group B. The number of enuresis episodes per a week (weekly) in a group C reached: before treatment 5.3 (1.5), after treatment 1.0 (0.8), 3 three months after the end of treatment 0.7 (0.7). The percentage of patients with PMNE in a group C was significantly less immediately after the course of treatment (17.4%), and three months after treatment (24.6%).Conclusion: Combined treatment of therapy-resistant enuresis with use of Alarm Intervention and Reboxetine gives a high percentage of cured patients both immediately after therapy (82.6%) and three months after the end (75.4%).

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Primary Monosymptomatic Nocturnal Enuresis: Monotherapy vs Combination Therapy

Cited by 14 publications

References 31 publications

Comparison of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agents in the management of paediatric monosymptomatic nocturnal enuresis: a network meta‐analysis

Comparison of desmopressin, alarm, desmopressin plus alarm, and desmopressin plus anticholinergic agents in the management of paediatric monosymptomatic nocturnal enuresis: a network meta‐analysis

Nocturnal enuresis in india: Are we diagnosing and managing correctly?

Combination of Alarm-intervention and Reboxetine in Therapy- Resistant Enuresis

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