Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the larynx

Abstract

We may assume that chronic laryngitis could be a precursor to MALT lymphoma. This case is the first one to our knowledge of a primary MALT lymphoma of the larynx treated with conservative management combining surgical excision, reflux therapy, and eradication of gastric H. pylori infection.

Imaging Characteristics of Primary Laryngeal Lymphoma

“…4 Although 90% of tumors involving the larynx are squamous cell carcinoma, 5 laryngeal lymphoma is an important differential consideration because lymphoma is treated with chemoradiation instead of surgery. [1][2][6][7][8][9] Early detection of lymphoma allows improved patient care and may result in decreased dissemination of the disease process. 10,11 The purpose of this study was to identify imaging features of laryngeal lymphoma that could differentiate it from the far more common squamous cell carcinoma of the larynx and thus aid in the early detection of this rare tumor and lead to its proper treatment.…”

Anaplastic Lymphoma Kinase-positive Primary Diffuse Large B-cell Lymphoma of the Larynx: A Rare Clinical Entity

“…3 Kania et al reported MALT laryngeal lymphomas to be treated primarily by surgical excision. 33 Flow cytometry and karyotypic analysis accurately helps in diagnosis and subclassification of lymphomas as well as in the determination of prognostic indicators by extensive cellular phenotypic characterization of the tumor specimen. 3 This helps the oncosurgeons in creating patient-specific treatment protocols.…”

Lymphomas of the Head and Neck

“…184,185 Individual case reports have described patients with Sjögren's syndrome, 186 rheumatoid arthritis, 187 or chronic laryngitis secondary to extraesophageal reflux with Helicobacter pylori gastritis. 188 In rare cases patients are HIV positive 97,183 or have another underlying immunodeficiency. 189 Patients present with hoarseness, dyspnea, progressive or acute airway obstruction, sore throat, foreign body sensation, or dysphagia.…”

“…37,97,181,184,185 The tumors usually are smooth surfaced, submucosal, raised, often polypoid lesions. 183,184,188,190 Circumferential involvement of the larynx is also described. 186 Pedunculated tumors may prolapse into the airway.…”

“…Their histologic and immunophenotypic features are similar to those found in other sites (Figure 3-20). 37,181,182,[184][185][186][187][188]190 Marginal zone lymphomas may form lymphoepithelial lesions in submucosal glands (Figure 3-20, B). 188 Rare cases of follicular lymphoma 181 and peripheral T-cell lymphoma, 184,191 several cases of extranodal NK/T-cell lymphoma, 183,191,192 and an EBV+ B-cell lymphoma in a boy with Wiskott-Aldrich syndrome 189 have been described.…”