Primary non-secretory plasma cell leukemia with atypical morphology — a case report

Dadu, Tina; Rangan, Aruna; Handoo, Anil; Bhargava, Manorama

doi:10.1007/s12288-009-0019-1

Cited by 9 publications

(10 citation statements)

References 4 publications

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“…Such morphological variations have been reported more commonly in plasma cell leukemia. These include monocytoid appearing plasma cells with cleaved nuclei, hairy cell-like cells, blastoid cells, and cases with lympho-plasmacytoid cells, few showing bipolar cytoplasmic projections (2)(3)(4). In our series, all the six cases had clinical features suggestive of plasma cell dyscrasias.…”

Section: Discussionmentioning

confidence: 62%

Plasma cell myeloma with unusual morphology–A series of 6 cases

Hussain

Rahman

Nityanand

2014

European J of Haematology

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Morphological variants of plasma cells have been described in cases of Plasma cell neoplasm. Presence of these atypical forms poses difficulty in morphological diagnosis and demands the use of ancillary techniques to ascertain the nature of these atypical cells. We hereby report a series of 6 such cases where the bone marrow examination showed plasma cells with atypical morphology, leading to varied differential diagnosis; however immunophenotyping by flow cytometry in adjunct to serum electrophoresis, immunofixation and free light chain assays confirmed the diagnosis.

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Section: Discussionmentioning

confidence: 62%

Plasma cell myeloma with unusual morphology–A series of 6 cases

Hussain

Rahman

Nityanand

2014

European J of Haematology

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“…Immunohistochemistry, flow cytometric analyses and/or electron microscopic examination may be required to establish a definitive diagnosis. The diagnosis may be made with further difficulty in cases with a nonsecretory nature (7,9). Indeed, we did not initially suspect a diagnosis of PCL in patient 1 because most of the cells exhibited an atypical morphology, and no monoclonal proteins were detected in either the serum or urine.…”

Section: Discussionmentioning

confidence: 93%

“…Nonsecretory myeloma is also a rare form of MM characterized by the absence of monoclonal immunoglobulins on either serum or urine electrophoresis and represents less than 1% of cases of MM (4). Only a few well-documented cases of nonsecretory MM presenting as primary PCL have been reported (5)(6)(7)(8)(9). We herein report two elderly cases of primary nonsecretory PCL.…”

Section: Introductionmentioning

confidence: 88%

Two Cases of Nonsecretory Multiple Myeloma Presenting as Primary Plasma Cell Leukemia

et al. 2014

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Plasma cell leukemia (PCL) is a rare variant of multiple myeloma (MM) with a poor prognosis. Nonsecretory myeloma is also a rare form of MM characterized by the absence of detectable M-protein in the serum and urine. This report describes two cases of nonsecretory PCL. The first patient was an 85-year-old man in whom the lack of monoclonal immunoglobulins made it difficult to make a diagnosis because the malignant cells showed an atypical morphology. He died of rapid disease progression before starting chemotherapy. The second patient was a 78-year-old woman whose tumor cells displayed a typical plasma cell morphology. She was successfully treated with bortezomib-containing chemotherapy.

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“…The exact incidence of pPCL is believed to be less than 1 case/million. [ 7 ] From the surveillance, epidemiology and end results (SEER) database it is evident that there are no significant differences based on gender, age, or race when compared with patients with MM. PCL occurs in all races and all geographic locations.…”

Section: Discussionmentioning

confidence: 99%

“…As with MM, PCL is more common in African Americans and blacks from Africa than in whites. [ 7 ] pPCL patients have a younger age at presentation when compared to MM or sPCL patients, and their performance status is usually worse and faster declining. [ 1 ] pPCL presents at a slightly younger age with median ages at diagnosis of 55 compared to patients with sPCL at 66.…”

Section: Discussionmentioning

confidence: 99%