Primary Open-Angle Glaucoma and Serum Lipids

Abstract

The aim of this paper was to prove the relation between serum lipid values (cholesterol, triglyceride, low density cholesterol, high density cholesterol and primary open -angle glaucoma. The study includes two patient groups: 50 patients with primary open-angle glaucoma and 50 patients without this disease. However, all 100 patients were tested for serum lipid values. The research covered a period of six months (from May to December 2007.). Primary open-angle glaucoma was diagnosed with intraocular pressure values (between 20,1 and 25,6 mm Hg) measured with Schiotz tonometry. The visual field changes were confirmed with Goldmann perimetry. The gonioscopies were done for diagnosis confirmation. The serum lipid values were confirmed with enzymatic colorimetry in vitro method. U-test (Mann-Witney-Wilcox test) and t-test, as nonparametric tests, were used for statistical evaluations. The cholesterol mean value in the test group was 6,14 mol/dm (3) (3,20-8,10 mol/dm (3)) whereas in the control group it was 5,96 mol/dm(3) (2,70-8,80 mol/dm(3)). U-test was with negative ranks (z=-0,83 AS=0,678). The triglyceride mean value in the test group was 2,38 mol/dm (3) (0,84-11,73 mol/m (3)) and in the control group it was 2,04 mol/dm (3) (0,63-5,89 mol/dm(3)). U-test was with positive ranks (z=0,950 AS=0,342). High density cholesterol was average in the test group with 1,45 mol/dm (3) (0,71-3,40 mol/dm (3)) and in the control group 1,40 mol/m (3) (0,80-3,20 mol/dm (3)). Low density cholesterol in the test group was 3,98 mol/m (3) (1,82-6,49 mol/m (3)) and in the control group 4,08 mol/m (3) (2,69-5,69 mol/m (3)). These results had positive ranks according to U-test. Serum lipid values could be one of predictable factors in primary open-angle glaucoma diagnosis. Due to the patient age, cholesterol values, as common factors in primary open-angle glaucoma and atherosclerosis genesis, could be concern in the same aetiology based on dyslipidaemia as well.

A Survey of the Relationship Between Serum Cholesterol and Triglyceride to Glaucoma: A Case Control Study

“…The researches tested 50 patients with open-angle glaucoma and 50 healthy individuals with respect to their serum lipids and it was found that cholesterol level in the case group was 6.14mol/dm and in the control group it was 2.04mol/dm. It was, then, concluded that the amount of serum lipids can act as a predictive factor in contracting glaucoma, which is in accord with the result of the present study [23].…”

The Role of Plasma Lipid Profile in Patients with Type A Behavior Pattern with POAG

“…On the other hand, it is also well known that Ldl-cholesterol stimulates local production of endothelin -1 with strong vasoconstrictive action on the ciliary arteries, with a further unbalancing of the relationship with nitric oxide, with vaso-dilating action [18] , and deregulation of aqueous outflow through the trabecular meshwork (TM). This hypothesis also seems to be confirmed by other studies emphasizing that the reduction in cholesterol, though at levels initially within the norm, involves a reduction in the risk of developing POAG and a slowing of the evolution of the campimetrical damage in affected people [19] . The role of the impairment of the lipid profile is also underlined by the observation that therapy with statins [20,21] , which markedly influence the reduction in LDL-cholesterol levels, is what ensures the best protection against glaucomatous damage.…”

Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma

“…Having presumed glaucoma a vascular disorder, one should investigate the role of dyslipidemia in its etiopathogenesis. Indeed, there is research showing increased levels of TC, TG and LDL, and decreased HDL in POAG and NTG patients [35][36][37]. Furthermore, one population analysis has linked dyslipidemia with increased IOP in people not receiving glaucoma treatment, suggesting that hyperlipidemia may play a role in the onset of glaucoma [38].…”