Primary Pericardial Osteosarcoma in an Elderly Patient

Tsang, KH; Cheung, TY; Chan, William; Chan, MK

doi:10.12809/hkjr1515294

Cited by 1 publication

(2 citation statements)

References 9 publications

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“…To our knowledge, our research represents the only large-scale study of APS II and APS III in Asia ( 16 , 17 , 18 , 19 , 26 , 27 ), with previous research primarily focusing on adult APS types conducted in Western countries ( 5 , 13 , 15 , 28 , 29 , 30 ). The comparison of studies on adult APS types is summarized in Table 5 , but the inclusion criteria varied among these studies.…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesize that there may exist variations in both the clinical presentation and pathogenesis among distinct adult subtypes of APS ( 15 ). It is worth noting that the majority of published studies have predominantly focused on Western countries, with limited research dedicated to investigating APS within the Asian population ( 16 , 17 , 18 , 19 ). Therefore, in our study, we specifically aim to examine the clinical and serological characteristics of APS II and APS III within Taiwan.…”

Section: Introductionmentioning

confidence: 99%

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A 20-year study of autoimmune polyendocrine syndrome type II and III in Taiwan

Tseng,

Lin,

Lin

et al. 2023

European Thyroid Journal

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Purpose: Autoimmune polyendocrine syndrome (APS) is a rare immune-endocrinopathy characterized by the failure of at least two endocrine organs. Clinical characteristics have mainly been described in the Western population. This study comprehensively analyzed the demographic and clinical manifestations of APS-II and APS-III in Taiwan. Methods: Patients aged ≥ 20 years with a diagnosis of APS-II or APS-III in ten hospitals between 2001 and 2021 were enrolled. The clinical and serological characteristics of the patients were retrospectively reviewed. Results: Among the 187 enrolled patients (45 men and 142 women); only seven (3.7%) had APS-II, while the others had APS-III. Fifty-five patients developed hyperthyroidism and 44 patients developed hypothyroidism. Men were diagnosed with APS at a younger age than women (16.8 vs. 27.8 years old, p=0.007). Most patients were initially diagnosed with type 1 diabetes mellitus. There was a positive correlation between age at diagnosis and the likelihood of developing thyroid dysfunction. For every year older patients were diagnosed with APS-III, the risk of developing hyperthyroidism increased by 3.6% (p=0.002), and the risk of developing hypothyroidism increased by 3.7% (p=0.035). Positive anti-parietal cell antibodies (APCA) were associated with a higher risk of anemia in patients with APS-III (p< 0.001). Conclusion: This study provides the most comprehensive analysis of APS-II and APS-III in Asia. The percentage of patients with APS-II was significantly lower than in the Western population. A second autoimmune endocrinopathy may develop several years after the first one. APCA examination is valuable when evaluating anemia in patients with APS.

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