Primary Peripheral Nerve Sheath Tumors of the Thyroid Gland

Kandil, Emad; Khalek, Mohammed Abdel; Abdullah, Obai; Dali, Dali; Faruqui, Sabeen; Khan, Amna; Friedlander, Paul; Jaffe, Bernard M.; Crawford, Byron E.

doi:10.1089/thy.2009.0245

Cited by 24 publications

(17 citation statements)

References 19 publications

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Section: Discussionmentioning

confidence: 76%

“…Intrathyroidal schwannomas have been reported globally and most occur in the 40- to 60-year-old age group [1]. Unlike most reported cases of thyroid schwannomas whose FNA findings were often inconclusive [1,3,4,8], our preoperative FNA yielded spindle-shaped cells. The differential diagnosis of spindle cell lesions includes neural derived tumors, mesenchymal lesions (leiomyoma, solitary fibrous tumor, hemangiopericytoma), epithelial tumors (anaplastic thyroid cancer - particularly if the tumor cells undergo degeneration), medullary thyroid cancer, thymoma, spindle epithelial tumor with thymus-like differentiation (SETTLE), and hyalinizing trabecular adenoma.…”

Section: Discussionmentioning

confidence: 76%

“…These peripheral nerve growth tumors occur in the extremities as well as the head and neck [1]. Head and neck schwannomas can mimic thyroid nodules whether they present as cervical or (rarely) intrathyroidal lesions [2,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Head and neck schwannomas can mimic thyroid nodules whether they present as cervical or (rarely) intrathyroidal lesions [2,3,4]. Presurgical diagnosis can be challenging as these lesions are often mistaken for thyroid nodules [1,4]. Here we present a case in which magnetic resonance imaging (MRI) and the unique characteristics of schwannomas on MRI facilitated the correct presurgical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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A Cervical Schwannoma Masquerading as a Thyroid Nodule

et al. 2017

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Background: We present a case of a cervical schwannoma, likely originating from the pharyngeal plexus of the vagal nerve. The lesion masqueraded as a thyroid nodule and magnetic resonance imaging (MRI) assisted in preoperative diagnosis. We review the radiographic characteristics of nerve sheath tumors on MRI as well as the diagnostic cytologic stains which can enhance the possibility of a correct preoperative diagnosis. Case: We describe a 60-year-old female with dysphagia and a neck mass consistent with a nodular goiter. The patient's history, diagnostic images, cytology, pathology, and surgical management are presented and analyzed. The preoperative diagnosis of a cervical schwannoma was suspected by the use of MRI which led to additional specialized cytologic stains. Conclusion: Pharyngeal wall schwannomas are important to consider in the differential diagnosis of thyroid nodules when fine needle aspiration cytology indicates cells of neural origin. Imaging by MRI can assist in identifying lesions of neural origin masquerading as thyroid nodules.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Cervical Schwannoma Masquerading as a Thyroid Nodule

et al. 2017

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“…Neurilemmomas arise from Schwann cells. It is usually difficult to make a diagnosis by fine-needle aspiration because follicular cells are absent and the aspirated cells are hard to identify (2). Given that hereditary nonmedullary thyroid cancer is more aggressive, histopathologic diagnosis is recommended.…”

mentioning

confidence: 99%

Neurilemmoma of the Thyroid Gland

Jong

Lee²,

Chan³

et al. 2012

Intern. Med.

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A 42-year-old woman was noted to have a left neck lump in a health check-up. One year earlier, her mother was diagnosed to have poorly differentiated thyroid cancer. Ultrasound revealed a polygonal hypoechoic lesion without calcifications (Picture 1; asterisk, left thyroid). Fine-needle aspiration cytology was inconclusive. Based on suspicious ultrasonographic characteristics, she was brought to the operating room for diagnostic lobectomy. At surgery, a plane was identified between the well-encapsulated tumor and the thyroid gland. Enucleation was performed. Frozen section revealed characteristic nuclear palisading with Verocay bodies (Picture 2).The thyroid gland is close to laryngeal nerves and is innervated by sympathetic nerve branches (1). Neurilemmomas arise from Schwann cells. It is usually difficult to make a diagnosis by fine-needle aspiration because follicular cells are absent and the aspirated cells are hard to identify (2). Given that hereditary nonmedullary thyroid cancer is more aggressive, histopathologic diagnosis is recommended.

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Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid

Rossi

Pantanowitz

Hornick

2021

Cancer Cytopathology

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Thyroid tumors can be classified into epithelial, nonepithelial, and nonprimary lesions. Nonepithelial thyroid tumors are rare. They can be of primary origin within the thyroid gland, arise secondary to contiguous growth from adjacent tissues, or represent metastatic disease. The incidence of nonepithelial tumors of the thyroid is only 1% to 2%, most of which are lymphomas; the remainder includes mesenchymal and histiocytic tumors. This review examines the cytohistological features of various nonepithelial and nonlymphoid tumors of the thyroid, including vascular lesions, neural tumors (including granular cell tumor and paraganglioma), smooth muscle tumors, solitary fibrous tumor, histiocytic neoplasms (eg, Langerhans cell histiocytosis and Rosai‐Dorfman disease), and follicular dendritic cell sarcoma. Their differential diagnosis is discussed, including recommendations to prevent the pitfall of mistaking these rare tumors for more common epithelial thyroid neoplasms.

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Primary Peripheral Nerve Sheath Tumors of the Thyroid Gland

Abstract: Schwannomas of the thyroid gland are extremely rare and usually asymptomatic. Complete surgical resection is mandatory for care.

Cited by 24 publications

References 19 publications

A Cervical Schwannoma Masquerading as a Thyroid Nodule

A Cervical Schwannoma Masquerading as a Thyroid Nodule

Neurilemmoma of the Thyroid Gland

Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid

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