Primary pulmonary leiomyosarcoma: A population-based study

Qin, Bao‐Dong; Jiao, Xiao‐Dong; Zang, Yuan‐Sheng

doi:10.1016/j.lungcan.2017.12.015

Cited by 34 publications

(72 citation statements)

References 17 publications

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“…Similar results were also observed in a previous study of 183 patients with leiomyosarcoma of the urinary bladder . We also found that most of the patient population was white (83.2%), which was also consistent with the findings from the previous study . However, sex, primary site, laterality, and year of diagnosis were not related to the OS and CSS of PL‐LMS patients via multivariate analysis.…”

Section: Discussionsupporting

confidence: 92%

“…Localized stage was associated with better OS and CSS than advanced stage. The previous study also reported that advanced stage was a poor prognostic factor for OS and CSS in leiomyosarcoma patients . Partial resection and radical excision or resection of the lesion with limb salvage were related to better OS and CSS compared with PL‐LMS patients without surgery..…”

Section: Discussionmentioning

confidence: 77%

“…Leiomyosarcoma (LMS) is a rare sarcoma of soft tissue that arises from smooth muscle cells and can occur anywhere in the body. On the basis of the location of the tumor, LMS is classified into uterine, lung, vascular, cutaneous, bladder, somatic, gastrointestinal, and limbs subsets. These subtypes of LMS present with various clinical behaviors and rate of survival.…”

mentioning

confidence: 99%

“…Previous studies have revealed that distant stage and surgical resection were prognostic factors in patients with primary lung leiomyosarcoma . In addition to undifferentiated tumor grade and failure to undergo cancer‐directed surgery, increasing age and distant disease were also associated with reduced disease‐specific survival (cancer‐specific survival [CSS]) in patients with leiomyosarcoma of the urinary bladder .…”

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confidence: 99%

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Nomograms Predict Cancer‐Specific and Overall Survival of Patients With Primary Limb Leiomyosarcoma

Wang

Hong

Meng

et al. 2019

Journal Orthopaedic Research

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To date, there have been no data to predict the survival of patients with leiomyosarcoma from soft limb tissue because of the rarity of this disease. Nomograms have been widely applied in clinical oncology to precisely predict the survival of individual patients. This was a retrospective study to construct and validate nomograms to predict the cancer-specific survival (CSS) and overall survival (OS) of patients with primary limb leiomyosarcoma (PL-LMS). A total of 1,208 patients with LMS from limb soft tissue were collected from the Surveillance, Epidemiology, and End Results database from 1975 to 2015. We identified independent prognostic factors using univariate and multivariate Cox analyses. These prognostic factors were then included in the nomograms to predict 3-and 5-year CSS and OS rates. Finally, we validated the nomograms internally and externally. A total of 1208 patients were collected and divided into validation (N = 604) and training (N = 604) groups. Age, race, grade, tumor size, stage, and surgical types were demonstrated as independent prognostic factors for CSS and OS (all p < 0.05) and further used to construct the nomograms. The concordance index (C-index) for CSS was 0.857 for internal validation and 0.727 for external validation. The C-index for OS and CSS both demonstrated that the nomogram prediction agreed perfectly with actual survival. We developed nomograms to predict CSS and OS in PL-LMS patients and can benefit from using them to identify patients' mortality risk and make more precise assessments regarding survival.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Nomograms Predict Cancer‐Specific and Overall Survival of Patients With Primary Limb Leiomyosarcoma

Wang

Hong

Meng

et al. 2019

Journal Orthopaedic Research

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“…The overall survival information was also identified and extracted from the SEER database, which was defined as the interval from diagnosis until death or the last follow-up. 7 Because the SEER research data are publicly available and all data are deidentified, institutional review board approval and informed consent are not required for this study. In addition, all authors have signed the research agreement form and received permission from the SEER to access the database.…”

Section: Methods and Materials Participantsmentioning

confidence: 99%

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

Bai

Zhao

Pan

2019

CMAR

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Background: Small cell carcinoma (SmCC) of the salivary gland is rare, and the characteristics and survival are not well defined due to only case reports or case series being reported. The present study aimed to describe the clinicopathological characteristics and determine the factors associated with survival of this rare cancer. Materials and methods: A population-based study was carried out to investigate clinical characteristics and prognosis of SmCC of the salivary gland using prospectively extracted data from the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2016. Results: Totally, 198 patients with SmCC of the salivary gland were identified with an average age of 72.6±12.4 and a male to female ratio of 3.4:1. The lesions of most patients (167/198) were located in the parotid gland. The median overall survival (mOS) of all patients is 25.0 months. The 1-, 3-, 5-and 10-year survival rate was 65.7%, 40.9%, 33.0% and 22.7%, respectively. Surgery could prolong significantly the mOS by almost 17.0 months (28.0 months vs 11.0 months; P<0.01). Radiotherapy, as well as radiotherapy after surgery, could prolong the mOS (P<0.01 for both). Patients who received chemotherapy had significantly longer overall survival time than those without chemotherapy (28.0 months vs 20 months; P=0.04). The survival analysis demonstrated that old age (>72 years), lymph node (N3) and distant metastases were independent factors for poor survival, whereas radiotherapy was an independent factor for favorable survival. Conclusion: Small cell carcinoma of the salivary gland is a rare disease, and old age, lymph node and distant metastases, and radiotherapy were significantly associated with prognosis. In order to understand this disease more thoroughly, more cases with adequate information are required.

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Diagnosis of pulmonary leiomyosarcoma extending into the main bronchus using repeated transbronchial cryobiopsy

Tsukamoto

Kitajima

Marumo

et al. 2022

Respirology Case Reports

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The diagnosis of pulmonary leiomyosarcoma using bronchoscopy is difficult, and surgical resection is often performed for definitive diagnosis and curative therapy. We report a case of pulmonary leiomyosarcoma, successfully diagnosed using repeated transbronchial cryobiopsy (TBCB). A 69‐year‐old‐woman was found to have an oval mass in the left hilar region extending into the left main bronchus on computed tomography (CT). All transbronchial biopsy specimens were necrotic, but repeated TBCB removed the necrotic tissue from the tumour and finally led to the diagnosis of pulmonary leiomyosarcoma. Proton therapy was administered, which caused shrinkage of the tumour. Thus, TBCB is useful for definitive diagnosis of leiomyosarcoma without surgical biopsy. Repeated TBCB can reduce tumour volume, eliminate atelectasis, and reduce the extent of radiotherapy exposure.

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Primary pulmonary leiomyosarcoma: A population-based study

Cited by 34 publications

References 17 publications

Nomograms Predict Cancer‐Specific and Overall Survival of Patients With Primary Limb Leiomyosarcoma

Nomograms Predict Cancer‐Specific and Overall Survival of Patients With Primary Limb Leiomyosarcoma

<p>Clinicopathological Characteristics and Survival of Small Cell Carcinoma of the Salivary Gland: a Population-Based Study</p>

Diagnosis of pulmonary leiomyosarcoma extending into the main bronchus using repeated transbronchial cryobiopsy

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