Primary pulmonary lymphoma presenting as nodules and masses: a case report and literature review

Gao, Xiaofang; Peng, Yan

doi:10.4081/monaldi.2021.1259

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…In the present case, radiologic findings included diffuse, bilateral, multiple tiny nodules mimicking pulmonary metastasis, miliary tuberculosis (TB), and fungal infection. Similar reported cases ( 3 4 ) have depicted such multiple nodular manifestations in patients with malignant lymphoma.…”

Section: Introductionsupporting

confidence: 81%

Diffuse Large B-Cell Lymphoma Manifesting as Miliary Nodules in the Lung: A Case Report

Na,

Kwon,

Kim

et al. 2023

J Korean Soc Radiol

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Malignant lymphoma has various pulmonary manifestations on chest CT, including nodules, masses, areas of consolidation, and ground-glass opacity. These presentations can pose a diagnostic challenge, as they mimic other disease patterns. Herein, we report a case of diffuse large B-cell lymphoma (DLBCL) manifesting as miliary nodules in a 67-year-old male initially presenting with dyspnea and fever. Radiologic findings included diffuse, bilateral, multiple tiny nodules consistent with metastasis, miliary tuberculosis, and fungal infection. However, further investigations, including laboratory tests, imaging, and biopsies, led to the diagnosis of DLBCL involving the lungs. Herein we reported a rare case of lymphoma involvement of the lung presenting as miliary nodules. Accurate diagnosis relies on a comprehensive evaluation of the clinical history, physical features, laboratory test results, and imaging findings.

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Section: Introductionsupporting

confidence: 81%

Diffuse Large B-Cell Lymphoma Manifesting as Miliary Nodules in the Lung: A Case Report

Na,

Kwon,

Kim

et al. 2023

J Korean Soc Radiol

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“…Therefore, PPL is usually highly misdiagnosed in clinical practice. [8] Computed tomography (CT) is a well-established modality routinely used for the initial diagnostic of lung lesion in clinical practice. Several studies have been conducted to describe the CT appearance of PPL, which showed a variety of findings, including single or multiple nodules or masses with uniform density or pneumonia-like consolidations.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a CT-based radiomics model for differentiating pneumonia-like primary pulmonary lymphoma from infectious pneumonia: A multicenter study

Kang

Nie

et al. 2023

Chinese Medical Journal

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Background: Pneumonia-like primary pulmonary lymphoma (PPL) was commonly misdiagnosed as infectious pneumonia, leading to delayed treatment. The purpose of this study was to establish a computed tomography (CT)-based radiomics model to differentiate pneumonia-like PPL from infectious pneumonia. Methods: In this retrospective study, 79 patients with pneumonia-like PPL and 176 patients with infectious pneumonia from 12 medical centers were enrolled. Patients from center 1 to center 7 were assigned to the training or validation cohort, and the remaining patients from other centers were used as the external test cohort. Radiomics features were extracted from CT images. A three-step procedure was applied for radiomics feature selection and radiomics signature building, including the inter-and intra-class correlation coefficients (ICCs), a one-way analysis of variance (ANOVA), and least absolute shrinkage and selection operator (LASSO). Univariate and multivariate analyses were used to identify the significant clinicoradiological variables and construct a clinical factor model. Two radiologists reviewed the CT images for the external test set. Performance of the radiomics model, clinical factor model, and each radiologist were assessed by receiver operating characteristic, and area under the curve (AUC) was compared. Results: A total of 144 patients (44 with pneumonia-like PPL and 100 infectious pneumonia) were in the training cohort, 38 patients (12 with pneumonia-like PPL and 26 infectious pneumonia) were in the validation cohort, and 73 patients (23 with pneumonia-like PPL and 50 infectious pneumonia) were in the external test cohort. Twenty-three radiomics features were selected to build the radiomics model, which yielded AUCs of 0.95 (95% confidence interval [CI]: 0.94 -0.99), 0.93 (95% CI: 0.85 -0.98), and 0.94 (95% CI: 0.87-0.99) in the training, validation, and external test cohort, respectively. The AUCs for the two readers and clinical factor model were 0.74 (95% CI: 0.63-0.83), 0.72 (95% CI: 0.62-0.82), and 0.73 (95% CI: 0.62-0.84) in the external test cohort, respectively. The radiomics model outperformed both the readers' interpretation and clinical factor model (P <0.05). Conclusions:The CT-based radiomics model may provide an effective and non-invasive tool to differentiate pneumonia-like PPL from infectious pneumonia, which might provide assistance for clinicians in tailoring precise therapy.

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Primary pulmonary lymphoma presenting as nodules and masses: a case report and literature review

Cited by 2 publications

References 10 publications

Diffuse Large B-Cell Lymphoma Manifesting as Miliary Nodules in the Lung: A Case Report

Diffuse Large B-Cell Lymphoma Manifesting as Miliary Nodules in the Lung: A Case Report

Development and validation of a CT-based radiomics model for differentiating pneumonia-like primary pulmonary lymphoma from infectious pneumonia: A multicenter study

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