Primary Pure Squamous Cell Carcinoma of the Breast

Siegelmann‐Danieli, Nava; Murphy, Timothy J.; Meschter, Steven; Stein, Moshe; Prichard, Jeffrey W.

doi:10.3816/cbc.2005.n.030

Cited by 36 publications

(37 citation statements)

References 16 publications

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“…Estrogen and progesterone receptors are negative in more than 90% of the cases of pure SCCB 8,11,12 which was also proven in our case. The only case of HER-2/neu over expression in SCCB was reported by Karamouzis et al 11 There is only one reported case of a BRCA 1 gene mutation in a patient with SCCB.…”

Section: Discussionsupporting

confidence: 78%

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Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual case

Mitra

Pal

Debnath

et al. 2011

International Journal of Surgery Case Reports

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Section: Discussionsupporting

confidence: 78%

“…Patients typically report a breast mass that enlarged over a period of 2-3 weeks, or in some cases for as long as 18 months. 4,8 Primary tumors tend to be relatively large (range 2-5 cm, median 4 cm). 4,10 Our case was 58-year-old with duration of the disease four months, which is supported by literature.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual case

Mitra

Pal

Debnath

et al. 2011

International Journal of Surgery Case Reports

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“…To the best of our knowledge, only six patients with these tumors, which presented clinically as breast abscess, have been reported previously [11]. There are no findings on mammography specific to this diagnosis, which may explain the more-advanced disease stage at diagnosis [12,13]. Breast ultrasound has been reported to be more helpful with these tumors appearing as solid hypoechogenic masses with complex cystic components [14].…”

Section: Discussionmentioning

confidence: 82%

“…This means that hormonebased therapy may not be effective in these tumors. HER2/neu is also usually not over-expressed or amplified in this disease [12]. A little review suggests that PPSCC is not sensitive to chemotherapeutic agents commonly used for ductal carcinoma [6,22].…”

Section: Discussionmentioning

confidence: 99%

Pure Primary Squamous Cell Carcinomas of the Breast: A Report of Eight Cases

Znati

2010

J Med Cases

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Pure primary squamous cell carcinoma (PPSCC) of the breast is a rare neoplasm included in World Health Organization Classification of tumors (2003) in metaplastic breast cancer. It accounts for less than 0.1% of all breast carcinomas. We performed a retrospective review of all women diagnosed or treated as PPSCC, from January 2004 to June 2009 to assess clinical presentation, surgical and pathological findings, treatment and outcome. Eight patients were identified. The median age was 48.2 (range: 40 -57) years. The average tumor size was 7.3 cm, with a range of 3.5 to 18 cm. There were one well differentiated, three moderately differentiated and four poorly differentiated PPSCC. Two cases were stage IIA, two cases stage IIIA and three cases stage IIIB. Primary treatment was mastectomy in six patients and large local excision in one patient. There was lymph node (LN) involvement in one patient. Estrogen and progesterone receptors status and over expression of HER 2 were assessed and none tumors was positive. Cytokeratin 5/6 and/ or Cytokeratin 14 were positive in all tumors. All patients were treated by radiotherapy and chemotherapy. Though PPSCC of the breast is a very rare and aggressive disease, in our experience it's relatively frequent. Strict histologic criteria should be used to diagnose PPSCC, because they have significantly lower axillary lymph node metastasis, lower estrogen and PR positivity, and they are often treatment-refractory. The role of different new chemotherapy regimens needs to be explored.

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“…According to Siegelmann-Danieli et al, estrogen and progesterone receptors are negative in more than 90% of pure squamous cell carcinomas of the breast. 23 The treatment for SCC of the breast is similar to that of other malignant breast tumors. Although a conservative approach to the breast can be used, many of these patients already present locally advanced disease at diagnosis, thus precluding breast conservation.…”

Section: Discussionmentioning

confidence: 93%

Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

Damin¹,

Nascimento²,

Andreola³

et al. 2011

Sao Paulo Med. J.

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Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsisresUMo CONTEXTO: O carcinoma de células escamosas da mama é um câncer extremamente raro, representando cerca de 0,04% dos tumores malignos da mama. Até o momento, apenas um número limitado de casos da doença foi relatado, a maioria se apresentando clinicamente como um carcinoma de mama usual. RELATO DE CASO: Paciente feminina de 39 anos de idade se apresentando com grande abscesso de mama e sinais de sepse. Após debridamento cirúrgico da lesão, o exame histopatológico da cápsula do abscesso revelou a presença de carcinoma de células escamosas da mama. O tratamento definitivo do tumor foi uma mastectomia radical modificada com ressecção da lesão residual na mama direita. CONCLUSÃO: O presente caso, de apresentação incomum, demonstra como uma lesão aparentemente benigna, como um abscesso mamário, pode estar relacionada a uma neoplasia maligna oculta. Uma revisão da literatura a respeito do carcinoma de células escamosas de mama é apresentada.I MD, PhD. Attending Physician,

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Primary Pure Squamous Cell Carcinoma of the Breast

Cited by 36 publications

References 16 publications

Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual case

Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual case

Pure Primary Squamous Cell Carcinomas of the Breast: A Report of Eight Cases

Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

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