Primary rectal melanoma in an African female: case report

Kuka, Werimo Pascal; Gatheru, Joseph; Mwanzi, Sitna; Onyango, Nelson Owuor; Rajula, Allan

doi:10.11604/pamj.2022.41.286.33128

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The surgical treatment decision (LE vs APR) should be individualized 9,10 . Temperley et al 9 performed a metaanalysis that included 10 studies and 303 patients.…”

Section: Discussionmentioning

confidence: 99%

A rare case of a primary malignant anorectal melanoma

Văcărașu¹,

Iosifescu²,

Anton³

et al. 2023

Public Health Toxicol

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“…The surgical treatment decision (LE vs APR) should be individualized 9,10 . Temperley et al 9 performed a metaanalysis that included 10 studies and 303 patients.…”

Section: Discussionmentioning

confidence: 99%

A rare case of a primary malignant anorectal melanoma

Văcărașu¹,

Iosifescu²,

Anton³

et al. 2023

Public Health Toxicol

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“…Malignant melanoma in the rectum is extremely unusual, and Kusuma et al described 2 occurrences: one in a 60-year-old man and one in a 51-year-old man, both of whom were successfully treated by APR and local excision [7]. In their study, Kuka et al described a case of primary rectal melanoma in a 58-year-old African woman who had lower abdomen pain with occasional rectal bleeding for 3 months before undergoing a colonoscopy, which revealed a rectal polypoid mass in the anorectal region [8].…”

Section: Discussionmentioning

confidence: 99%

Primary amelanotic melanoma of anorectum – a rare case report with diagnostic challenge

Singh,

Singh

2023

pjp

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Anorectal melanoma is an exceptionally rare and aggressive form of cancer. One per cent of anorectal malignant tumours are anorectal malignant melanomas, which are exceedingly uncommon. We report a case of a 47-year-old woman who experienced painless rectal bleeding. On examination, an irregular lump was seen in the posterior rectal wall, measuring 4 × 3.7 cm. Biopsies were obtained under endoscopic guidance for histomorphology and immunohistochemistry. The biopsy examination showed nests of tumour mass in the lamina and muscularis mucosae. The tumour mass was composed of round to oval cells having enlarged nuclei, conspicuous nucleoli, and a scant amount of cytoplasm. No melanin pigmentation was noted in the tumour cells. HMB-45, S-100, and vimentin were all detected by immunohistochemistry. A definitive diagnosis of amelanotic malignant melanoma was rendered. The patient underwent abdominoperineal resection with a hysterectomy and bilateral salpingo-oophorectomy. Anorectal melanoma presents with bleeding per rectum and is often misdiagnosed as internal haemorrhoids or adenocarcinoma clinically. Amelanotic melanoma, which lacks melanin pigment, is difficult to diagnose. Patients who appear with rectal bleeding should have a malignant melanoma evaluation as a possible differential diagnosis, and suitable diagnostic procedures, such as a colonoscopy and a biopsy with immunohistochemistry, should be carried out to arrive at a conclusive diagnosis.

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Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma

Paolino,

Podo Brunetti,

De Rosa

et al. 2024

Melanoma Research

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Anorectal melanoma (ARM) is a rare malignancy often associated with a poor prognosis due to its late diagnosis and aggressive biological behavior. This review aims to comprehensively investigate ARM’s diagnosis, management, and treatment, emphasizing its clinical characteristics, laboratory findings, and implications for patient prognosis. A systematic literature search was conducted in PubMed, Embase, and Cochrane CENTRAL databases from inception to 1 July 2024. This review synthesizes existing literature to provide a comprehensive understanding of this rare primary malignancy. A total of 110 articles reporting on 166 patients were included. Gender data were available for 131 cases, comprising 67 females (51.1%) and 64 males (48.9%). The median age was 66 years. The overall median time to diagnosis was 4 months for anal melanoma, 3 months for rectal melanoma, and 4 months for anorectal junction melanoma. The clinical presentation was nodular in 98.2% of cases. Pre-diagnosis symptoms included bleeding in 84.9% of cases, mucous elimination (6%), pain (68.7%), tenesmus (16.9%), and changes in bowel movements (28.5%). Overall survival (OS) was reported in 82 cases, with a median OS of 11 months: 11 months for anal melanoma, 7 months for rectal melanoma, and 12 months for anorectal junction melanoma. ARM is a rare and aggressive melanoma subtype often diagnosed at an advanced stage, leading to a poor prognosis. A female predominance was observed, consistent with other mucosal melanomas. Anal melanoma exhibited better progression-free survival, and OS compared to rectal and anorectal junction melanoma.

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Primary rectal melanoma in an African female: case report

Cited by 3 publications

References 9 publications

A rare case of a primary malignant anorectal melanoma

A rare case of a primary malignant anorectal melanoma

Primary amelanotic melanoma of anorectum – a rare case report with diagnostic challenge

Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma

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