Primary renal MALT lymphoma presenting with cryoglobulinaemia

Charitaki, Evangelia; Liapis, Konstantinos; Moutzouris, Dimitrios Anestis; Marinos, Leonidas; Adamidis, Konstantinos; Margellos, Vasilios; Bakiri, Maria

doi:10.1093/ndt/gfr478

Cited by 7 publications

(13 citation statements)

References 8 publications

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“…Immunophenotype is less specific. 9 In our case, the neoplasm was diagnosed as a MALTtype lymphoma because of the presence of lymphoepithelial lesions, centrocyte-like cells admixed with reactive lymphocytes, plasmacytoid cells and plasma cells with the characteristic immunophenotype (e.g., CD138, CD20, CD3, CD43 positivity and CD10, CD30, bcl-6 negativity).…”

Section: Discussionmentioning

confidence: 75%

“…Uni-or bilateral kidney enlargement had been proposed in the past as one of the criteria to diagnose primary renal lymphoma; however, our case questions this criterion by presenting a solitary renal mass. 9 In the imaging, renal MALToma often mimics other kidney diseases, such as renal cell carcinoma, angiomyolipoma, oncocytoma, renal pelvic carcinoma, other types of lymphoma and xanthogranulomatous pyelonephritis -all of which should be considered in the differential diagnosis. Immunophenotype is less specific.…”

Section: Discussionmentioning

confidence: 99%

“…3 To the best of our knowledge, only 8 cases have been published until now (Table 1). [2][3][4][5][6][7][8][9] We report a case of primary renal lymphoma of mucosa-associated lymphoid tissue in an 82-year-old woman who presented with a 5-cm solid mass in the left kidney.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary renal MALToma: A rare differential diagnosis for a recurrent renal mass after primary ablative therapy

Vedovo

Pavan

Liguori

et al. 2014

CUAJ

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary renal MALToma: A rare differential diagnosis for a recurrent renal mass after primary ablative therapy

Vedovo

Pavan

Liguori

et al. 2014

CUAJ

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“…Secondary renal involvement in non-Hodgkin’s lymphoma is common, but primary renal lymphoma is extremely rare [ 9 , 10 ]. MALT lymphomas arise from various anatomic sites, but the most frequent is the stomach.…”

Section: Discussionmentioning

confidence: 99%

Mucosa-Associated Lymphoid Tissue Lymphoma Involving the Kidney and Renal Pelvis

Gromicho¹,

Araújo²,

Oliveira³

et al. 2021

Cureus

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Mucosa-associated lymphoid tissue (MALT) lymphomas are a distinctive group of B-cell lymphomas. These lymphomas arise from various anatomic sites and are mainly seen in the gastrointestinal tract, but the primary involvement of the kidney is extremely rare. We report a case of a MALT lymphoma involving the kidney and the renal pelvis. A 56-year-old man presented with a history of hematuria and left flank pain. A computed tomography scan showed a marked tissue densification in the renal sinus, suggesting marked thickening of the urothelium, conditioning deformity of the renal pelvis and calyces. A cystoscopy confirmed a 2-cm papillary lesion on the left lateral aspect of the bladder. The patient underwent laparoscopic radical nephoureterectomy and transurethral bladder resection. The pathological diagnosis was MALT lymphoma in the kidney and urothelial carcinoma of the bladder. The patient was referred to a hematologist and was free of disease at 20 months of follow up without additional treatment.

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“…The lymphoma cells express surface monotypic immunoglobulins, or, more rarely, cytoplasmic immunoglobulin, usually IgM. Additionally, monoclonal gammopathy is a common phenomenon in MALT lymphoma, most likely due to paraprotein production by clonal lymphoplasmacytic cells 8 , 26 , 27. Approximately one-third of extragastric MALT lymphomas have extensive plasma cell differentiation, which permits the differential diagnosis with plasmacytomas or lymphoplasmacytic lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Renal small B-cell lymphoma with plasmacytic differentiation presenting with monoclonal gammopathy and disseminated intravascular coagulation syndrome

Prestes

Zenatti

Sousa

et al. 2013

ACR

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Primary renal lymphomas are very rare. However, the kidney may be a site of metastasis, usually from a disseminated aggressive lymphoma. A 58-year-old woman was brought to the medical facility due to acute mental confusion, severe hypotension, septic shock, and signs of disseminated intravascular coagulation. Laboratory tests showed severe leukopenia, renal failure, altered liver function, and elevated serum lactate dehydrogenase levels. Protein electrophoresis revealed hypergammaglobulinemia with a monoclonal peak of IgG lambda. The clinical outcome was fulminant and the patient died less than 24 hours after admission. Autopsy revealed an indolent B-cell lymphoma with extensive plasmacytic differentiation infiltrating the right renal sinus and involving the submandibular and sublingual glands, cervical and peri-aortic lymph nodes, multiple microscopic foci in pituitary and adrenal glands, lung, breast, liver, thyroid, and bone marrow. Numerous IgG4-positive plasma cells were detected by immunohistochemistry although other histological features of IgG4-related disease were missing. There was also extensive hemorrhagic necrosis of the adrenal glands and purulent cystitis, which was probably responsible for the septic shock. The authors concluded that the kidney was most likely the primary site of the indolent lymphoma, as that was the site with the largest tumor mass. Infiltration of other organs was considered as dissemination of the disease. The differential diagnosis with mucosa-associated lymphoid tissue and lymphoplasmacytic lymphoma is discussed.

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Primary renal MALT lymphoma presenting with cryoglobulinaemia

Cited by 7 publications

References 8 publications

Primary renal MALToma: A rare differential diagnosis for a recurrent renal mass after primary ablative therapy

Primary renal MALToma: A rare differential diagnosis for a recurrent renal mass after primary ablative therapy

Mucosa-Associated Lymphoid Tissue Lymphoma Involving the Kidney and Renal Pelvis

Renal small B-cell lymphoma with plasmacytic differentiation presenting with monoclonal gammopathy and disseminated intravascular coagulation syndrome

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