Primary results from the Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy (CD PROBE)

Jankovic, Joseph; Adler, Charles H.; Charles, David; Comella, Cynthia L.; Stacy, Mark; Schwartz, Marc; Adams, Aubrey Manack; Brin, Mitchell F.

doi:10.1016/j.jns.2014.12.030

Cited by 69 publications

(69 citation statements)

References 24 publications

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“…As a secondary objective we evaluated for differences in the efficacy of BoNT among these two groups. The demographics of our study population were similar to those reported in the literature when considering age and gender 14,15. Comparison of the underlying diagnoses of our patient population to the literature was difficult as most studies either included only patients with idiopathic cervical dystonia16,19 or included cervical dystonia of any etiology without further delineating underlying diagnoses 12,15,17.…”

Section: Discussionmentioning

confidence: 75%

Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study

Patterson

Almeida

Hess

et al. 2016

Tremor and Other Hyperkinetic Movements

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Section: Discussionmentioning

confidence: 75%

Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study

Patterson

Almeida

Hess

et al. 2016

Tremor and Other Hyperkinetic Movements

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“…In a meta-analysis (8 trials with 361 patients using Ona"oNT"; 5 trials with 319 patients using "bo"oNT"), it was shown that there was a statistically and clinically signiicant improvement on objective rating scales and subjective rating scales as well as for pain relief in subjective scales [7]. The same was also seen in a realworld design study (1046 patients) showing robust improvement in clinical ratings as measured via both physician-and subject-reported outcomes and excellent tolerability following Ona"oNT" treatment of CD [30].…”

Section: Treatment Of Cervical Dystoniamentioning

confidence: 66%

“…Reviews of "oNT treatment for CD suggest that 70-90% of patients derive symptomatic beneit from "oNT with at least one injection [29][30][31]. In a meta-analysis (8 trials with 361 patients using Ona"oNT"; 5 trials with 319 patients using "bo"oNT"), it was shown that there was a statistically and clinically signiicant improvement on objective rating scales and subjective rating scales as well as for pain relief in subjective scales [7].…”

Section: Treatment Of Cervical Dystoniamentioning

confidence: 99%

“…In the CD-PRO"E registry, the mean time between treatments increased from 14.6 ± 4.1 weeks following treatment session 1 to 15.1 ± 5.2 weeks after treatment session 2 [30].…”

Section: Treatment Of Cervical Dystoniamentioning

confidence: 99%

“…The most common events were weakness (6.9%, 185 subjects), dysphagia (6.2%, 65 subjects), and neck pain (2.3%, 24 subjects) [30].…”

Section: Adverse Eventsmentioning

confidence: 99%

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How Effective and Safe is Botulinum Toxin Therapy in Cervical Dystonia: The Current Stand

Jamora¹,

Piano²

2016

Botulinum Toxin Therapy Manual for Dystonia and Spasticity

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Cervical dystonia (CD) is the most common focal dystonia that is characterized by involuntary contraction of cervical muscles causing abnormal head movements and postures. The treatment for CD was previously limited to oral medications, however, with consequent systemic side efects. In recent years, botulinum toxin ("oNT) has demonstrated eicacy in several studies and thus has received level " recommendation from both the "merican "cademy of Neurology and the European Federation of Neurological Sciences in the treatment of dystonia. In many countries, it is the irst-line treatment for CD. There are four types of toxin approved for the use in CD, three type " [Onabotulinumtoxin" (Ona"oNT"), "bobotulinumtoxin" ("bo"oNT"), and Incobotulinumtoxin " (Inco"oNT")] and one type " [Rimabotulinumtoxin" (Rima-"oNT")]. Proper selection of afected muscles and dose of toxin are important parameters in successfully providing symptomatic treatment. Good response rate is deined as improvement of more than 25 % from baseline using the Toronto Western Torticollis Rating Scale. The most common side efect of chemodenervation with "oNT for CD is dysphagia.

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Therapeutic Benefit of Sensory Trick in Cervical Dystonia

Mahajan,

Gonzalez,

Stebbins

et al. 2023

Movement Disord Clin Pract

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BackgroundSensory tricks (STs) are voluntary maneuvers that dampen the abnormal movement in cervical dystonia (CD).ObjectivesTo investigate the effect of ST on CD severity and treatment.MethodsData on 1039 individuals with a modified Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score were extracted from the CD Patient Registry for Observation of OnabotulinumtoxinA (onabotA) Efficacy study. Univariate and multivariate models evaluated the direct and indirect impact of ST on CD severity and treatment, while controlling for confounds.ResultsComplete ST was associated with a 10% lower mean onabotA dose. Absence of complete ST was associated with a higher onabotA dose after controlling for dystonia severity (OR = 1.37, p = .04). ST moderated the relationship between dystonia severity and toxin dose (β = −.16, p = .02).ConclusionsST is related to lower CD severity and toxin dose. It may have a direct effect on lowering toxin dose, independent of CD severity.This article is protected by copyright. All rights reserved.

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Primary results from the Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy (CD PROBE)

Abstract: Results indicate robust improvement in clinical ratings and excellent tolerability following onabotulinumtoxinA treatment of CD.

Cited by 69 publications

References 24 publications

Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study

Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study

How Effective and Safe is Botulinum Toxin Therapy in Cervical Dystonia: The Current Stand

Therapeutic Benefit of Sensory Trick in Cervical Dystonia

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