Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease in Turkey

Parlak, Erkan; Koşar, Y.; Ülker, Aysel; Dağlı, Ülkü; Alkım, Canan; Şahın, Burhan

doi:10.1097/00004836-200110000-00008

Cited by 22 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the incidence of this progressive cholestatic liver disease is rare (3%), it requires careful follow-up since it is a slowly progressive disease over many years and leads to hepatic failure. In a recent paper from Turkey, Parlak et al [27]identified an incidence of 2.3% in their PSC population, which was similar to our own findings. The mean age at diagnosis was 43.6 in patients with UC.…”

Section: Discussionsupporting

confidence: 90%

Ulcerative Colitis in Kuwait: A Review of 90 Cases

et al. 2003

View full text Add to dashboard Cite

Background: Chronic ulcerative colitis is a disease of unknown etiology. Its incidence is on the rise in various developing countries as has been reported in studies from South-East Asia and the Middle East. There seems to be significant differences in the pattern and the clinical course of this disease in our patient population. The aim of our study is to assess the incidence and the clinical course of the disease in Kuwait. Methods: This is a retrospective study of cases identified over a period of 14 years (1985–1999). Three hundred forty-six patients were identified to have chronic ulcerative colitis. Ninety patients were interviewed for this study. Results: Chronic ulcerative colitis is being identified with increasing frequency. Our local incidence was 2.8 per 100,000 persons per year. The disease was seen in both sexes with equal frequency. It peaks at the third decade of life, with no second peak observed in the sixth decade. The disease was of mild to moderate severity in 93% of the cases. The distribution of the disease in the colon showed pancolitis in 45%, left-sided colitis in 14%, proctosigmoiditis in 21% and proctitis in 20%. Arthritis and arthralgia were the most frequent extraintestinal manifestation seen in 31%. Perianal disease, although rare in ulcerative colitis, was seen in 8%. Of interest is the fact that over 14 years of follow-up, none of our patients developed high-grade dysplasia or colorectal cancer. Four patients required total colectomy mainly due to failure of medical therapy. Conclusions: Chronic ulcerative colitis is occurring with increasing frequency similar to that seen in Western countries. The disease observed in our patient population was of mild to moderate severity, with fewer complications than reported in Western countries. It peaks in the third decade with no second peak. None of our patients developed high-grade dysplasia or colorectal carcinoma.

show abstract

Section: Discussionsupporting

confidence: 90%

Ulcerative Colitis in Kuwait: A Review of 90 Cases

et al. 2003

View full text Add to dashboard Cite

show abstract

“…However, studies from Central Asia and the Middle East have more variable results. Generally, PSC-IBD concurrence rates in these regions are reported as similar to those in Europe, but PSC-UC concurrence rates are much lower, often under 60%[ 16 , 60 , 61 ]. Lastly, some regions, such as central and southern Europe, Alaska, and northern Canada have identified either very low or even no concurrence of PSC with IBD[ 62 - 64 ].…”

Section: Primary Sclerosing Cholangitis and Inflammatory Bowel Diseasmentioning

confidence: 99%

“…The annual incidence of CCA among adult and pediatric patients with PSC is roughly 7%-9% across populations, though estimates in North America vary greatly, with reported incidences as low as 4% and as high as 20%[ 1 , 11 , 42 , 65 - 67 ]. The highest annual incidence of CCA is in Asia, with incidences as high as three times the global average; the reason for this elevated incidence is unknown (Table 1 )[ 16 , 35 , 60 , 68 , 69 ]. Interestingly, the highest non-PSC related rates of CCA are also seen in Asia, suggesting another variable ( e.g ., parasitic infections and chronic viral hepatitis) may be playing a role in the high rate of CCA[ 70 ].…”

Section: Primary Sclerosing Cholangitis and Neoplasiamentioning

confidence: 99%

Geoepidemiologic variation in outcomes of primary sclerosing cholangitis

Mehta

Weissman

Fung

et al. 2020

WJH

View full text Add to dashboard Cite

Primary sclerosing cholangitis (PSC) is a chronic, progressive, hepatobiliary disease characterized by inflammation and fibrosis of the intra- and extra-hepatic bile ducts. Its natural history is one that generally progresses towards cirrhosis, liver failure, cholangiocarcinoma, and ultimately disease-related death, with a median liver transplantation-free survival time of approximately 15-20 years. However, despite its lethal nature, PSC remains a heterogenous disease with significant variability in outcomes amongst different regions of the world. There are also many regions where the outcomes of PSC have not been studied, limiting the overall understanding of this disease worldwide. In this review, we present the geoepidemiologic variations in outcomes of PSC, with a focus on survival pre- and post-liver transplantation as well as the concurrence of inflammatory bowel disease and hepatobiliary neoplasia.

show abstract

“…The liver can be affected, as manifested by primary sclerosing cholangitis or autoimmune hepatitis. Disease-specific treatment has to be applied [36].…”

Section: Extra-intestinal Manifestationmentioning

confidence: 99%

Standards of medical treatment and nutrition in Crohn’s disease

Siegmund

Zeitz

2004

Langenbecks Arch Surg

View full text Add to dashboard Cite

Crohn's disease is a condition of chronic inflammation potentially involving any location of the alimentary tract from mouth to anus but with a propensity for the distal small bowel and proximal large bowel. Frequent complications include stricture and fistula. Numerous extra-intestinal manifestations may also be present. The aetiology of Crohn's disease is incompletely understood, and therapy, although generally effective in alleviating the symptoms, is not curative. Due to the heterogeneity of the disease a major need for the therapeutic approach is the ability to define subgroups with distinct characteristics. However, with regard to the heterogeneity of demographic, anatomic and disease behaviour characteristics, distillation of the numerous possible phenotypes in simple categories is a formidable task. In the present review the focus will be on clinically relevant situations providing therapeutic algorithms according to international guidelines.

show abstract

Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease in Turkey

Abstract: Prevalence of PSC-associated IBD in the Turkish community appear to be similar to the results of western origin studies.

Cited by 22 publications

References 10 publications

Ulcerative Colitis in Kuwait: A Review of 90 Cases

Ulcerative Colitis in Kuwait: A Review of 90 Cases

Geoepidemiologic variation in outcomes of primary sclerosing cholangitis

Standards of medical treatment and nutrition in Crohn’s disease

Contact Info

Product

Resources

About