Primary Serous Peritoneal Carcinoma Presenting First on a Routine Papanicolaou Smear

Wang, Hangjun; Chen, Patrick C.

doi:10.1159/000325189

Cited by 8 publications

(15 citation statements)

References 19 publications

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“…An asymptomatic, abdominal skin lesion that led to the diagnosis of PPSC was described by Cowan et al in 1995. 3 Another patient was diagnosed as having PPSC by a video-assisted thoracoscopic surgery due to bilateral pleural masses 4 , while three cases of PPSC [5][6][7] and one of serous peritoneal psammocarcinoma 8 were diagnosed by abnormal cytology ( Table 1). We report the fourth case of PPSC detected by abnormal cervical cytology, which is the first one with an absence of ovarian and tubal tissue at the time of the diagnosis.…”

Section: Cmentioning

confidence: 99%

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Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

Blontzos

Iavazzo

Giovannopoulou

et al. 2020

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Primary peritoneal serous carcinoma (PPSC) is a rare malignancy, the clinical characteristics of which resemble ovarian serous carcinoma. We present a rare case of PPSC detected by an abnormal cervical smear, the first one with an absence of ovarian tissue at the time of the initial diagnosis. A 59-year-old asymptomatic woman presented with glandular atypia on routine Papanicolaou smear. Endocervical and endometrial curettage showed an adenocarcinoma with focal squamous differentiation and uncertain further classification. The patient had a past surgical history of bilateral salpingoophorectomy due to endometriosis. Abdominal MRI depicted omental multinodularity, great amount of ascites and possible endometrial tumor. The patient underwent total hysterectomy, omentectomy and biopsies of implants on Douglass pouch.  Surgical and histological findings were consistent with primary peritoneal serous carcinoma.  Abnormal pap smear could rarely be suggestive of extrauterine malignancies, such as peritoneal cancer.

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Section: Cmentioning

confidence: 99%

“…B. 7 49 Asymptomatic High grade adenocarcinoma PPSC pian tubes. Serous tubal intraepithelial carcinoma is a precursor lesion of the fallopian tubes that has been found in many cases of both primary ovarian and peritoneal serous carcinomas and is considered to be the source of a significant proportion of these diseases.…”

Section: Amentioning

confidence: 99%

Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

Blontzos

Iavazzo

Giovannopoulou

et al. 2020

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“…Istraživanja pokazuju da se abnormalne stanice u Papa-testu kod primarnog karcinoma jajovoda mogu naći u do 26 % slučajeva 4 . Iako je primarna uloga Papa-testa detekcija lezija vrata maternice, nalaz malignih žljezdnih stanica u brisu, a u slučaju urednog kolposkopskog nalaza, histološke analize cerviksa i endometrija, treba pobuditi sumnju na ekstrauterine tumore i zahtijeva detaljnu obradu 11 . Recentna istraživanja tvrde da se maligne stanice ekstrauterinih tumora koje eksfoliraju u kavum uterusa mogu detektirati uzimanjem citoloških uzoraka endometrija četkicom 12 .…”

Section: Raspravaunclassified

The role of cytology in preoperative assessment od primary fallopian tube carcinoma: case report

et al. 2016

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Sažetak. Cilj:Prikazati slučaj pacijentice s primarnim seroznim karcinomom jajovoda, opisati dijagnostički postupak te analizirati ulogu citološke dijagnostike u detekciji ovog tipa tumora. Prikaz slučaja: Pedesetogodišnja pacijentica prethodno je obrađivana u drugoj ustanovi zbog bolova u trbuhu i radiološki dokazanih uvećanih supraklavikularnih, aortokavalnih i ilijačnih limfnih čvorova. Nakon učinjene laparoskopske ekstirpacije limfnih čvorova zbog sumnje na limfoproliferativnu bolest, patohistološkom i imunohistokemijskom analizom utvrđeno je da se radi o metastatskom adenokarcinomu, vjerojatno podrijetla iz ginekološkog sustava ili dojke. Radiološkom obradom dojki nisu pronađene promjene suspektne na malignitet. PET/CT analizom (pozitronska emisijska tomografija/kompjutorizirana tomografija) uočeno je pojačano nakupljanje radiofarmaka u predjelu vrata i tijela maternice. U preoperativnoj obradi učinjena je citološka punkcija uvećanog supraklavikularnog limfnog čvora te je imunocitokemijskom analizom utvrđeno da se radi o metastatskom seroznom adenokarcinomu. U Papa-testu pronađene su maligne stanice jednake morfologije, bez tumorske dijateze, što je upućivalo na ekstrauterini adenokarcinom, a sugerirano je podrijetlo jajnika ili jajovoda. Učinjena je eksplorativna kiretaža, ali je patohistološki nalaz bio uredan. Pacijentica je predviđena za histerektomiju s obostranom adnekstektomijom. Tijekom operativnog zahvata uočeno je proširenje desnog jajovoda tumorskim tkivom koje je probijalo stijenku jajovoda. Učinjena je lavaža peritonealne šupljine u kojoj su pronađene maligne stanice adenokarcinoma. Patohistološka analiza potvrdila je da se radi o primarnom seroznom karcinomu jajovoda s metastazama u jajnicima. Zaključak: Zahvaljujući brzini i preciznosti primijenjenih citodijagnostičkih pretraga dijagnostičko-terapijski postupak pravilno je usmjeren i pravovremeno proveden. Prikazani slučaj potvrđuje da citološka analiza može pridonijeti dijagnostici tumora s neuobičajenom kliničkom prezentacijom ili tumora nejasnog podrijetla.

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“…In the liquid-based Pap test, cells collected from the cervix are placed in an alcohol-based fixative for examination [3]. Notably, ovarian cancer cells have been observed in Pap tests [4][5][6], suggesting that ovarian cancer peptide biomarkers may also be present. We hypothesized that proteins shed by ovarian cancer cells can be detected during routine Pap tests by mass spectrometry (MS)-based proteomics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the potential of Pap test fluid and cervical swabs to serve as clinical diagnostic biospecimens for the detection of ovarian cancer by mass spectrometry-based proteomics

et al. 2021

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Background The purpose of this study was to determine whether the residual fixative from a liquid-based Pap test or a swab of the cervix contained proteins that were also found in the primary tumor of a woman with high grade serous ovarian cancer. This study is the first step in determining the feasibility of using the liquid-based Pap test or a cervical swab for the detection of ovarian cancer protein biomarkers. Methods Proteins were concentrated by acetone precipitation from the cell-free supernatant of the liquid-based Pap test fixative or eluted from the cervical swab. Protein was also extracted from the patient’s tumor tissue. The protein samples were digested into peptides with trypsin, then the peptides were run on 2D-liquid chromatography mass spectrometry (2D-LCMS). The data was searched against a human protein database for the identification of peptides and proteins in each biospecimen. The proteins that were identified were classified for cellular localization and molecular function by bioinformatics integration. Results We identified almost 5000 proteins total in the three matched biospecimens. More than 2000 proteins were expressed in each of the three biospecimens, including several known ovarian cancer biomarkers such as CA125, HE4, and mesothelin. By Scaffold analysis of the protein Gene Ontology categories and functional analysis using PANTHER, the proteins were classified by cellular localization and molecular function, demonstrating that the Pap test fluid and cervical swab proteins are similar to each other, and also to the tumor extract. Conclusions Our results suggest that Pap test fixatives and cervical swabs are a rich source of tumor-specific biomarkers for ovarian cancer, which could be developed as a test for ovarian cancer detection.

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Primary Serous Peritoneal Carcinoma Presenting First on a Routine Papanicolaou Smear

Cited by 8 publications

References 19 publications

Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

The role of cytology in preoperative assessment od primary fallopian tube carcinoma: case report

Evaluation of the potential of Pap test fluid and cervical swabs to serve as clinical diagnostic biospecimens for the detection of ovarian cancer by mass spectrometry-based proteomics

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