Primary signet ring cell carcinoma of the cervix: A case report with review of the literature

Wang, You-Chen; Yu, Yen-Lin; Fan, Chung-Wei; Huang, Shu‐Mei

doi:10.1016/j.tjog.2018.10.017

Cited by 10 publications

(13 citation statements)

References 14 publications

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“…Due to its scarcity, management of primary cervical signet ring cell carcinoma is very blurry. In the early stages, reported cases demonstrate the efficiency of surgery as a primary choice followed by either radiotherapy or combined chemotherapy as an option [15] . Palliative chemotherapy alone is prescribed mostly at the advanced stage.…”

Section: Discussionmentioning

confidence: 99%

Primary signet ring cell carcinoma of the cervix: About an uncommon case report

Lazhar¹,

Slaoui²,

Rostoum

et al. 2023

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Primary signet ring cell carcinoma of the cervix: About an uncommon case report

Lazhar¹,

Slaoui²,

Rostoum

et al. 2023

International Journal of Surgery Case Reports

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“…8 Primary SRCCC is a rare malignancy, with only about 30 cases reported in the English literature. [4][5][6][7] According to Hamada et al, SRCC in its pure or predominant form is extremely rare, and SRCC usually coexists with the usual endocervical type or intestinal type. 7 Moreover, they also stated that the presence of SRCC components can be used to make a diagnosis of SRCC, and six previous cases were diagnosed as SRCCC using only the biopsy specimen.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there have only been a few cases of primary SRCCC, and details about its pathogenesis and prognosis remain unknown. [4][5][6][7] Systemic sclerosis (SSc) is an autoimmune disease characterized by the distinctive pathogenetic triad of microvascular damage, dysregulation of innate and adaptive immunity, and generalized fibrosis in multiple organs. 8 Based on the extent of the skin involvement, there are two subsets of SSc: limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc).…”

Section: Introductionmentioning

confidence: 99%

A rare case of signet ring cell carcinoma with diffuse cutaneous systemic sclerosis: A case report

Sano,

Yoshida,

Hibi

et al. 2023

J of Obstet and Gynaecol

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Systemic sclerosis, an autoimmune disease characterized by fibrosis and vasculopathy of the skin and other multiple organs has been associated with an increased risk of malignancy. We present the case of a 74‐year‐old woman who had diffused cutaneous systemic sclerosis and uterine cervical cancer. The patient was initially diagnosed with stage IIB squamous cell carcinoma and concurrent chemoradiotherapy was planned. However, cisplatin could not be administered due to acute renal failure, so the patient was treated solely with radiotherapy. However, complications of systemic sclerosis progressed rapidly, and the patient died 63 days later from pulmonary edema. An autopsy later revealed that uterine cervix had primary signet ring cell carcinoma. We suspected that this patient had a combination of signet ring cell carcinoma and squamous cell carcinoma, with squamous cell carcinoma disappearing after radiotherapy. This case highlighted the importance of systemic management for cancers associated with systemic sclerosis.

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“…There is no standardized recommendation. But in the early stage of the disease, surgical procedures followed by either radiotherapy or combined chemotherapy could be an option [1] . The prognosis of SRCC tends to be poor.…”

Section: Discussionmentioning

confidence: 99%

“…Adenocarcinoma accounts for 10–25% of cervical carcinomas; with the most frequent histological type is HPV-associated endocervical adenocarcinoma, usual type, followed by mucinous adenocarcinoma. Signet ring cell carcinoma is a rare variant of mucinous carcinoma [1] . Clinical findings of tumor in ovary or uterine was a secondary from the primary tumor in intestinal, that usually called Krukenberg tumor [2] .…”

Section: Introductionmentioning

confidence: 99%