Primary Sjögren’s Syndrome Adversely Affects the Female Sexual Function Assessed by the Female Sexual Function Index: A Case-Control Study

Yıldız, Çağlar; Karakuş, Savaş; Akkar, Özlem Bozoklu; Şahin, Ali; Bozkurt, Birkan; Yanık, Ali

doi:10.5606/archrheumatol.2017.6066

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…Studies on sexual dysfunction conducted in patients with SS and controlled by healthy women in the same age group using this specific instrument demonstrate significant impairment in the sexual life of SS patients. The results show lower means of total score, a lower frequency of sexual intercourse, and a worse index in the domains of lubrication and dyspareunia [5,[20][21][22].…”

Section: Sexual Dysfunctionmentioning

confidence: 88%

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

et al. 2021

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Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and need extra care regarding their sexual activity, reproductive health and during pregnancy, conditions that are not properly conducted in the clinical practice. To cover this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of symptoms, diagnosis, monitoring, prognosis, and treatment of these manifestations. A Focus Group meeting was held and included experts in the field and methodologists, based on a previously developed script, with themes related to the objective of the study. The most important topics were summarized and 11 recommendations were provided.

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Section: Sexual Dysfunctionmentioning

confidence: 88%

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

et al. 2021

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“…Twenty studies used the FSFI ( Gateva and Kamenov, 2012 ; Ercan et al , 2013 ; Ferraresi et al , 2013 ; Benetti-Pinto et al , 2014 ; Lara et al , 2015 ; Noroozzadeh et al , 2016 ; Shafti and Shahbazi, 2016 ; Yildiz et al , 2017 ; Basirat et al , 2019 ; Aydogan Kirmizi et al , 2020 ; Deniz and Kehribar, 2020 ; Akbari Sene et al , 2021 ; Mantzou et al , 2021 ; Naumova et al , 2021 ; Taghavi et al , 2021 ; Aba and Aytek Şik, 2022 ; Ashrafi et al , 2022 ; Çetinkaya Altuntaş et al , 2022 ; Daneshfar et al , 2022 ; Mojahed et al , 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Sexual function in women with polycystic ovary syndrome: a systematic review and meta-analysis

Pastoor,

Mousa,

Bolt

et al. 2024

Human Reproduction Update

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BACKGROUND Polycystic ovary syndrome (PCOS) is a common and distressing endocrine disorder associated with lower quality of life, subfertility, diabetes, cardiovascular disease, depression, anxiety, and eating disorders. PCOS characteristics, its comorbidities, and its treatment can potentially influence sexual function. However, studies on sexual function in women with PCOS are limited and contradictory. OBJECTIVE AND RATIONALE The aim was to perform a systematic review of the published literature on sexual function in women with PCOS and assess the quality of the research and certainty of outcomes, to inform the 2023 International Guidelines for the Assessment and Management of PCOS. SEARCH METHODS Eight electronic databases were searched until 1 June 2023. Studies reporting on sexual function using validated sexuality questionnaires or visual analogue scales (VAS) in PCOS populations were included. Random-effects models were used for meta-analysis comparing PCOS and non-PCOS groups with Hedges’ g as the standardized mean difference. Study quality and certainty of outcomes were assessed by risk of bias assessments and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) method according to Cochrane. Funnel plots were visually inspected for publication bias. OUTCOMES There were 32 articles included, of which 28 used validated questionnaires and four used VAS. Pooled Female Sexual Function Index (FSFI) scores in random-effects models showed worse sexual function across most subdomains in women with PCOS, including arousal (Hedges’s g [Hg] [95% CI] = −0.35 [−0.53, −0.17], I2 = 82%, P < 0.001), lubrication (Hg [95% CI] = −0.54 [−0.79, −0.30], I2 = 90%, P < 0.001), orgasm (Hg [95% CI] = −0.37 [−0.56, −0.19], I2 = 83%, P < 0.001), and pain (Hg [95% CI] = −0.36 [−0.59, −0.13] I2 = 90%, P < 0.001), as well as total sexual function (Hg [95% CI] = −0.75 [−1.37, −0.12], I2 = 98%, P = 0.02) and sexual satisfaction (Hg [95% CI] = −0.31 [−0.45, −0.18], I2 = 68%, P < 0.001). Sensitivity and subgroup analyses based on fertility status and body mass index (BMI) did not alter the direction or significance of the results. Meta-analysis on the VAS studies demonstrated the negative impact of excess body hair on sexuality, lower sexual attractiveness, and lower sexual satisfaction in women with PCOS compared to controls, with no differences in the perceived importance of a satisfying sex life. No studies assessed sexual distress. GRADE assessments showed low certainty across all outcomes. WIDER IMPLICATIONS Psychosexual function appears to be impaired in those with PCOS, but there is a lack of evidence on the related distress scores, which are required to meet the criteria for psychosexual dysfunction. Health care professionals should discuss sexual function and distress and be aware of the multifactorial influences on sexual function in PCOS. Future research needs to assess both psychosexual function and distress to aid in understanding the degree of psychosexual dysfunction in PCOS. Finally, more diverse populations (e.g. non-heterosexual and more ethnically diverse groups) should be included in future studies and the efficacy of treatments for sexual dysfunction should also be assessed (e.g. lifestyle and pharmacological interventions).

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“…This study is both innovative and important since it does a full analysis of the existing research on the connection between Sjogren's Syndrome and ED and investigates the various potential treatment approaches. [1][2][3][4][5][6][7]…”

Section: Introductionmentioning

confidence: 99%

The Mechanism in which Sjogren's Syndrome Contributes to The Onset of Erectile Dysfunction

Margiana

Azlansyah

2023

IABJ

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Sjogren's Syndrome is an autoimmune disorder characterized by the loss of salivary and lacrimal glands, resulting in dry mouth and eyes. Erectile dysfunction (ED) is a prevalent complaint among people with Sjogren's Disease, however the underlying mpoiechanism is not yet known. The purpose of this article is to examine the mechanism through which Sjogren's Disease causes ED and to identify potential therapies. Using MEDLINE, EMBASE, and the Cochrane Library databases, a systematic review was done. Papers investigating the link between Sjogren's Syndrome and ED published between 1990 and 2021 were included in the study. The review paper discusses a number of potential mechanisms for the association between Sjogren's Disease and ED. They include low levels of testosterone, endothelial dysfunction, autonomic neuropathy, and psychosocial issues. The article also discusses potential treatments for ED caused by Sjogren's Disease, including inhibitors of phosphodiesterase type 5, testosterone replacement therapy, and psychological counseling. The research implies a connection between Sjogren's Disease and ED, although the underlying mechanisms remain unknown. It is necessary to conduct additional studies to better comprehend the relationship and develop targeted remedies.

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Primary Sjögren’s Syndrome Adversely Affects the Female Sexual Function Assessed by the Female Sexual Function Index: A Case-Control Study

Cited by 9 publications

References 21 publications

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome

Sexual function in women with polycystic ovary syndrome: a systematic review and meta-analysis

The Mechanism in which Sjogren's Syndrome Contributes to The Onset of Erectile Dysfunction

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