Primary Sjogren syndrome

Pulmonary manifestations of Sjögren's syndrome

“…Purpura or leukocytoclastic vasculitis, sometimes mimicking urticaria, can also be encountered, especially in association with cryoglobulinaemia [25]. Extraglandular, extrathoracic involvement includes psychological manifestations, such as asthenia (70-80%), sleep disorder (15%), anxiety (20%) or depression (40%) [26]. Arthralgia and/or myalgia are estimated to be present in half the cases of Sjögren's syndrome, and symmetrical non-erosive arthritis can be observed.…”

“…Corticosteroids (ranging 0.5-1 mg·kg −1 ·day −1 with azathioprine or cyclophosphamide) are usually prescribed for NSIP patients, but with no evidence of efficacy [26,100]. In a cohort of 18 Sjögren's syndrome-ILD patients, PARAMBIL et al [36] described five patients with NSIP treated with corticosteroids associated with other drugs (hydroxychloroquine, azathioprine or cyclophosphamide).…”

Sjögren Syndrome and Pregnancy: A Literature Review

“…Dryness of mucosal surfaces occurs because of immune-mediated inflammation causing secretory gland dysfunction. 2 Sicca features primarily affect the quality of life, whereas the disease prognosis is marked by systemic involvement. 3 Sjögren syndrome is known to occur predominantly in women.…”

Oral Aspects of Sjögren’s Syndrome

“…Sicca symptoms of the disease could be treated by using topical agents wheras extraglandular features are managed with glucocorticoids and immunosuppressive drugs (40). But, literature search revealed no evidence based therapeutic guidelines for the management of primary Sjögren syndrome which is also universally accepted (41).…”

“…Alcohol and smoking should be avoided and thorough oral hygiene is essential (40,59). Saliva replacement products and sugarfree chewing gums may be effective for mild to moderate dry mouth (41).…”