Primary spinal cord oligodendroglioma: a case report and review of the literature

Abstract

Background: Primary spinal cord oligodendroglioma is extremely rare. In an extensive review of this disease, 53 cases were reported. Furthermore, the authors summarize the characteristics of the primary spinal cord oligodendroglioma; chronological presentation , neurological imaging, treatment and the outcome obtained in the present case as well as review the literature. Case Presentation: A 46-year-old male who had progressive neck pain for a year. Magnetic resonance imaging showed an intramedullary mass from level C2 to T4. A radical resection was performed. Histology revealed oligodendroglioma. Thereafter, the patient was treated with adjuvant radiotherapy. A year later, tumor developed recurrence. The patinet died in 3 years and 6 months. Conclusions: The available data of this disease was limited. Base on 11 published papers and the present case, surgical resection is the treatment of choice although recurrence of the tumor tends to occur after partial resection with or without radiotherapy. From the literature, the management of the recurrent disease is still surgery. Moreover, Temozolomide may be an advantage in recurrent situations.

A very rare spinal cord tumor primary spinal oligodendroglioma: A review of sixty cases in the literature

“…Although IM spinal cord tumors appear more frequently in pediatric than adult patients, adult PSOs are more common than pediatric PSOs. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 45 46 47 48 49 ] The clinical presentation of a PSO is similar to that of other IM spinal tumors, i.e., PSOs do not present with unique characteristic. PSO symptoms depend mostly on the anatomical site of the tumor and usually develop over a period spanning months to years.…”

“…[ 30 31 32 33 34 35 36 37 38 39 40 41 42 43 ] With the latest publications, including a few mini-clinical series and cases, the total number of reported cases of PSO is 60. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 ] Fortuna et al . found that PSO cases were equally distributed between both sexes and the literature to date indicates no significant sex predilection.…”

“…Symptom durations are shorter in pediatric patients than in adult patients. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 47 48 49 50 51 52 ] Regional back pain and sensory disturbances are the most frequent complaints, while motor and sphincter deficits occur later. [ 1 2 3 4 5 6 7 8 9 10 ] More infrequent symptoms include kyphoscoliosis, raised intracranial pressure, and spastic tetraparesis due to osseous changes.…”

“…Table 1 summarizes the reviewed cases [ Table 1 ]. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 ]…”

“…They constitute <2% of all intramedullary (IM) spinal tumors and sixty cases have been reported in the literature. [ 1 2 3 4 ] PSOs can occur in children and adults, and there is slight male predominance. Depending on the tumor's anatomical location, symptoms generally include motor deficits, sphincter dysfunction, pain, and sensory deficits.…”