Primary stenosis progression versus secondary stenosis formation in the left coronary bifurcation: A mechanical point of view

Jahromi, Reza; Pakravan, Hossein Ali; Saidi, Mohammad R.; Firoozabadi, Bahar

doi:10.1016/j.bbe.2018.11.006

Cited by 34 publications

(11 citation statements)

References 39 publications

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“…Patient 2′s OSI was higher than that of patient 1. Previous studies have shown that TAWSS > 40 dyne/cm 2 or high OSI (no exact value but generally > 0.2 or 0.3) lead to vascular wall damage, whereas TAWSS < 4 dyne/cm 2 and blood flow disorder can induce extensive platelet aggregation, damage endothelial cells, and lead to thrombosis and atherosclerosis ( Kroll et al, 1996 ; Park et al, 2016 ; Jahromi et al, 2019 ). Accordingly, there may be a risk of thrombotic development and plaque growth in the LAD of patient 1.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Characteristics of Patients With Suspected Coronary Heart Disease at Their Initial Visit

Cao

Zhao

et al. 2021

Front. Physiol.

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PurposeIt is difficult for doctors to decide whether patients with suspected coronary heart disease classified as Coronary Artery Disease Reporting and Data System (CAD-RADS) < 3 should be administered preventive treatment, or whether non-atherosclerotic chest pain should be considered. The aim of the current study was to investigate coronary hemodynamic characteristics in such patients, which may provide more information on their stenosis and be helpful for initial diagnoses.MethodsTwo patient-specific models were reconstructed based on the coronary computed tomographic angiography underwent in 2012. Patient 1 was classified as CAD-RADS 0, and was readmitted to hospital due to coronary artery disease within 5 years. Patient 2 was classified as CAD-RADS 2, and has experienced no adverse events to date. Computational fluid dynamics (CFD) analysis was used to obtain hemodynamic parameters including flow rate waveform, flow streamlines, time-average wall shear stress (TAWSS), and oscillatory shear index (OSI).ResultsPatient 1 exhibited no physiological characteristics of right coronary artery flow waveform, large areas of low TAWSS, and slow blood flow in the proximal and middle segments of the left anterior descending branch. Patient 2 exhibited reduced coronary supply, small and separate areas of abnormal TAWSS, and a higher left anterior descending branch OSI than patient 1.ConclusionHemodynamic abnormalities may play an important role in the prognosis of patients with coronary stenosis, and patient-specific hemodynamic characteristics may facilitate more accurate initial diagnosis, and better management. Overall hemodynamics (along the whole vessel) warranted attention at the time of the initial visit in patients classified as CAD-RADS < 3.

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Section: Discussionmentioning

confidence: 99%

Hemodynamic Characteristics of Patients With Suspected Coronary Heart Disease at Their Initial Visit

Cao

Zhao

et al. 2021

Front. Physiol.

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“…N.A-Not available. All images were adapted from [6,11,42,43,47,[57][58][59][60]64,[74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. N.A-Not available.…”

Section: Blood Flow Studies In Coronary Arteriesmentioning

confidence: 99%

“…Furthermore, hemodynamic studies mainly assume the wall to be rigid, however, over the years, fluid-structure interaction (FSI) has received increasing interest due to its ability to simultaneously model blood flow and arterial wall deformations [79,81,[98][99][100][101]. Among the several investigations that have emerged in this area, one of the most cited works in the literature was performed by Torii et al, (2009) [99], wherein the effects of compliance in WSS calculations were studied.…”

Section: Turbulence Modeling and Wall Assumptionsmentioning

confidence: 99%

Blood Flow Modeling in Coronary Arteries: A Review

Carvalho

Pinho

Lima

et al. 2021

Fluids

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Atherosclerosis is one of the main causes of cardiovascular events, namely, myocardium infarction and cerebral stroke, responsible for a great number of deaths every year worldwide. This pathology is caused by the progressive accumulation of low-density lipoproteins, cholesterol, and other substances on the arterial wall, narrowing its lumen. To date, many hemodynamic studies have been conducted experimentally and/or numerically; however, this disease is not yet fully understood. For this reason, the research of this pathology is still ongoing, mainly, resorting to computational methods. These have been increasingly used in biomedical research of atherosclerosis because of their high-performance hardware and software. Taking into account the attempts that have been made in computational techniques to simulate realistic conditions of blood flow in both diseased and healthy arteries, the present review aims to give an overview of the most recent numerical studies focused on coronary arteries, by addressing the blood viscosity models, and applied physiological flow conditions. In general, regardless of the boundary conditions, numerical studies have been contributed to a better understanding of the development of this disease, its diagnosis, and its treatment.

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“…9 Primary plaque length progression is more probable than secondary plaque formation distal to the stenosis when the stenosis degree increases. 10 Possible complications of arterial stenosis are hypertension. 11 Though there are reports about blood flow changes with progression of stenosis severity, 12,13 they neglect microcirculation function.…”

Section: Introductionmentioning

confidence: 99%

Fluid–structure interaction analysis of hemodynamics in different degrees of stenoses considering microcirculation function

Liu

Guo

2021

Advances in Mechanical Engineering

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In developed countries, stenosis is the main cause of death. To investigate hemodynamics within different degrees of stenoses, a stenosis model incorporating fluid–structure interaction and microcirculation function is used in this paper. Microcirculation is treated as a seepage outlet boundary condition. Compliant arterial wall is considered. Numerical simulation based on fluid–structure interaction is performed using finite element method. Our results indicate that (i) the increasing degree of stenosis makes the pressure drop increase, and (ii) the wall shear stress and the velocity in the artery zone may be more sensitive than the pressure with the increase of percentage stenosis, and (iii) there are higher wall shear stress and flow velocity in the post-stenosis region of severer stenosis. This work contributes to understand hemodynamics for different degrees of stenoses and it provides detailed information for stenosis and microcirculation function.

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Primary stenosis progression versus secondary stenosis formation in the left coronary bifurcation: A mechanical point of view

Cited by 34 publications

References 39 publications

Hemodynamic Characteristics of Patients With Suspected Coronary Heart Disease at Their Initial Visit

Hemodynamic Characteristics of Patients With Suspected Coronary Heart Disease at Their Initial Visit

Blood Flow Modeling in Coronary Arteries: A Review

Fluid–structure interaction analysis of hemodynamics in different degrees of stenoses considering microcirculation function

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