Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Inagaki, Hiroshi; Chan, John K.; Ng, Josephine W.M.; Okabe, Mitsukuni; Yoshino, Tadashi; Okamoto, Masanori; Ogawa, Hiroshi; Matsushita, Hiroshi; Yokose, Tomoyuki; Matsuno, Yoshihiro; Nakamura, Naoya; Nagasaka, Tetsuro; Ueda, Ryuzo; Eimoto, Tadaaki; Nakamura, Shigeo

doi:10.1016/s0002-9440(10)62569-2

Cited by 101 publications

(115 citation statements)

References 42 publications

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“…Long-term survival of patients with thymic MALT lymphoma after complete surgical resection without adjuvant chemotherapy or radiotherapy has been reported. 10) Because the oncologists did not recommend chemotherapy in the present case, the patient did not receive adjuvant chemotherapy. She was still alive without recurrence at the time of this writing (6 months postoperatively).…”

Section: Discussionmentioning

confidence: 91%

Surgery of Thymic Tumor with Persistent Left Superior Vena Cava

Yanagiya

Matsumoto

Hashimoto

et al. 2017

ATCS

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Because a persistent left superior vena cava (PLSVC) is a rare congenital malformation in the thoracic venous system, surgery of the thymus in such patients has rarely been reported. We herein present a case involving a 68-year-old woman who was treated for a thymic tumor adhering to a PLSVC. She underwent complete resection of the thymic tumor through median sternotomy with left-sided video-assisted thoracic surgery. Although the tumor was close to the left phrenic nerve, this nerve was safely preserved. The pathological diagnosis was mucosa-associated lymphoid tissue (MALT) lymphoma of the thymus. Thoracoscopy combined with median sternotomy enabled us to perform a safe surgical procedure for this patient.

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Section: Discussionmentioning

confidence: 91%

Surgery of Thymic Tumor with Persistent Left Superior Vena Cava

Yanagiya

Matsumoto

Hashimoto

et al. 2017

ATCS

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“…17 We have reported recently that VH3-23 and VH3-30 have been frequently used in thymic MALT lymphoma, a tumor closely associated with autoimmune disease. 18,26 Although the antigen specificity of antibodies encoded by VH3-23 and VH3-30 is currently unknown, it is suggested that B cells using these two VH fragments, which may be associated with H. pylori, are preferentially selected for MALT lymphomagenesis in the stomach. It has been controversial as to whether the majority of inflammation-dependent tumors progress to inflammationindependent tumors.…”

Section: Discussionmentioning

confidence: 99%

“…18,25,26 These primers have been used most commonly for VH gene analysis of malignant lymphoma. Subcloning of monoclonal PCR products was performed with pGEM T-easy vector (Promega, Madison, WI, USA) using DNA excised from the sharp rearrangement bands.…”

Section: Dna Extraction Vh Gene Amplification and Subcloningmentioning

confidence: 99%

Immunoglobulin VH gene analysis in gastric MALT lymphomas

et al. 2007

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The majority of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are successfully treated with Helicobacter pylori eradication alone. However, certain subsets of these tumors are resistant to the eradication treatment. As API2-MALT1 fusion is a feature of one of these subsets, we divided gastric MALT lymphomas into three groups: eradication-responsive and API2-MALT1 fusion-negative (Group A), eradication-resistant and fusion-negative (Group B), and eradication-resistant and fusion-positive (Group C). To characterize further gastric MALT lymphomas, we analyzed VH genes, which do not change in the course of tumor progression, by extensive subcloning of the monoclonal PCR products of 45 cases. VH3-23 and VH3-30 were preferentially used in Group A tumors (14/23 cases, 61%) as compared with Group B (1/10 cases, 10%, P ¼ 0.0094) and Group C (2/ 12 cases, 17%, P ¼ 0.017). Tumors of Groups B and C used variegated VH fragments, and no dominant VH fragments were noted. Somatic mutation was detected in most of the cases. Ongoing mutation was detected in 3/45 cases (7%), when assessed according to strict criteria for a confirmed mutation. These findings suggest that inflammation-dependent tumors (Group A) may be derived from a highly restricted, probably H. pyloriassociated, B cell subset and may not often progress to those that are inflammation-independent (Groups B and C). Although considered to be common in this tumor, ongoing mutation may be infrequent when assessed by strict criteria. Keywords: gastric MALT lymphoma; helicobacter pylori; eradication; immunoglobulin heavy chain variable genes; API2-MALT1 fusion gene Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct low-grade lymphoma, which is typically localized long term at the site of origin. 1 A preexisting chronic inflammation, such as Helicobacter pylori gastritis, Hashimoto's thyroiditis, or Sjogren's syndrome is considered to influence significantly its development. 1 The etiological link between gastric MALT lymphoma and H. pylori gastritis has arisen from the fact that the majority of gastric MALT lymphomas (approximately 70% of cases) show complete regression on eradication of H. pylori alone. 2 API2-MALT1 fusion, cloned from t(11;18)(q21;q21), is a gene alteration specific to MALT lymphomas. 3,4 API2 is a member of the IAP (inhibitor of apoptosis) gene family, and is essential for the suppression of apoptosis. 5 MALT1, a novel

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“…Briefly, DNA extracted from paraffin sections was amplified by PCR with primers (FR2A, FR3A, LJH, and VLJH) to detect rearrangement occurring between framework regions and the joining region of the immunoglobulin heavy chain gene. 33,34 Amplification of a ␤-globin DNA fragment (268 bp) was used to indicate satisfactory preservation of DNA in the sample. Monotypic immunoglobulin light chain was detected by immunohistochemistry for and light chains.…”

Section: Case Selectionmentioning

confidence: 99%

API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

Okabe

Inagaki

Ohshima

et al. 2003

The American Journal of Pathology

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t(11;18)(q21;q21) is associated with mucosa-associated lymphoid tissue (MALT)-type lymphoma and results in API2-MALT1 fusion. However, its clinicopathologic significance remains unclarified. API2-MALT1 fusion is detected most frequently in MALT lymphomas primarily involving the lung. We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule. The API2-MALT1 fusion transcript was detected in 21 of 51 (41%) cases, and was correlated with the absence of any underlying autoimmune disease, and with a normal serum lactate dehydrogenase, a "typical" histology without marked plasmacytic differentiation or an increased number of large cells, and aberrant nuclear BCL10 expression. However, its prognostic impact was not identified in the limited follow-up (6 to 187 months, median 27). These data suggest that the API2-MALT1 fusion may be a causative gene abnormality unrelated to autoimmune disease. In addition, this alteration may define a homogeneous MALT lymphoma subtype that is clinically more indolent and histologically more "typical.

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Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Cited by 101 publications

References 42 publications

Surgery of Thymic Tumor with Persistent Left Superior Vena Cava

Surgery of Thymic Tumor with Persistent Left Superior Vena Cava

Immunoglobulin VH gene analysis in gastric MALT lymphomas

API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

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